Fig. 3

T-cell responses to pooled peptides of the SARS-CoV-2 wild-type spike protein. PBMCs were stimulated with pooled peptides of the wild-type spike protein (all functional domains). The frequency of CD4 T cells (A) or CD8 T cells (B) expressing IL-17A, IFN-γ or FasL before (2CoVac) (N = 20) and 4 weeks after boosting with ChAdOx-1 (2CoVac + ChAd) (N = 10) and BNT162b2 (2CoVac + BNT) (N = 10) was determined using intracellular immunofluorescence staining and flow cytometry. Individual data points are shown. Lines represent the median with the interquartile range. The Mann–Whitney U test was used for comparisons. ns indicates no significant difference (p > 0.05), * p ≤ 0.05 and ** p ≤ 0.01