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Fig. 5 | Immunity & Ageing

Fig. 5

From: Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155

Fig. 5

Lm mutants differentially trigger weight loss and accumulation of CD8+ bTRM in young mice. 2 mo old C57BL/6 J mice were treated with antibiotics but not infected (○), or were infected with avirulent Lm mutants strain Δhly (▼, 1.6 × 107 CFU), or ΔactA (▲, 2.0 × 107 CFU), both from parent strain 10,403 s; or with wild type Lm strains 10,403 s (■, 3.2 × 106 CFU), or EGD (♦, 1.2 × 105 CFU). All mice were males with the exception that 4 M and 4 F mice were infected with EGD. A-D Symbols represent numbers of cells from individual mice harvested 29d-32d p.i. Significant differences between infected and uninfected mice are given as * p = 0.03, ** p = 0.001, and *** p < 0.0001. Significant differences between groups infected with different strains of Lm are shown. Significance was determined by 1-way Brown-Forsythe and Welch ANOVA with Dunnett’s T3 multiple comparisons post-test. Granulocytes in (C) were gated as CD11bhiCD45hiLy6CintSSChi, and represent mainly neutrophils but also include eosinophils. E Symbols represent mean percent of starting weight from 8 to 10 mice/group. Statistical significance calculated via 2-way ANOVA. Significance for selected comparisons: Uninfected v Δhly ns; Uninfected v. ΔactA p = 0.02; Uninfected v 10,403 s p < 0.0001; ΔactA v. 10,403 s p < 0.0001

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