Systemic Listeria monocytogenes infection in aged mice induces long-term neuroinflammation: the role of miR-155

Immunity & Ageing

Table 1 Analysis of upstream regulators and their predicted activation states in aged mice compared with young mice^a

Comparison of aged vs young	Upstream Regulator	Predicted Activation State	Activation z-score	p-value
Uninfected	PTGS1	Activated	2.575	0.0316
	HGF	Activated	2.131	0.0015
	BCL6	Inhibited	−2.531	0.0011
Infected	IGF1	Activated	2.424	0.0279
	ITGB2	Activated	2.419	0.0212
	PTGS2	Activated	2.319	0.0419
	RAC1	Activated	2.247	0.0198
	SPI1	Activated	2.176	0.00028
	IL1A	Activated	2.038	0.000091
	TNF	Activated	2.004	0.0000015

^a Complete gene lists were analyzed in Ingenuity Pathways Analysis®. Results shown are upstream regulators with activation Z-scores ≥2.0 or ≤ −2.0 and a p-value of < 0.05. Statistical significance calculate via right-tailed Fisher’s Exact Test

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