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Fig. 4 | Immunity & Ageing

Fig. 4

From: Poly-γ-glutamic acid/Alum adjuvanted pH1N1 vaccine-immunized aged mice exhibit a significant increase in vaccine efficacy with a decrease in age-associated CD8+ T cell proportion in splenocytes

Fig. 4

Changes in proportion and gene levels of CD8+ T cells in aged mice by PGA/Alum. A UMAP dimensionality reduction embedding CD8+ T cells within CD45+ cells isolated from the splenocytes of the vaccine-aged (1,322 cells), vaccine-PGA/Alum-aged (1,254 cells), and vaccine-young mice (1,793 cells) (pool of n = 3 per group) and differential representation of CD8+ T cell subsets. B Scaled gene expression within CD8+ T cells. C Heat-map analysis using gene expression profiles within CD8+ T cells. The representative significant difference of gene expression with bar graph. *P < 0.05, **P < 0.01, and ***P < 0.001

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Immunity & Ageing

ISSN: 1742-4933

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