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Fig. 2 | Immunity & Ageing

Fig. 2

From: Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells

Fig. 2

Systemic inflammation and the response to influenza vaccination in young (YA) and older (OA) adults, stratified by vaccine dose (standard [SD] or high [HD] dose). Natural log-transformed antibody titres against the seasonal circulating strain of influenza A/H1N1, A/H3N2 and B, and PBMC IFN-γ and IL-10 secretion in response to ex vivo A/H3N2 challenge were measured at 4-weeks post-vaccination and regressed against pre-vaccination natural-log transformed TNF or IL-6 (A), or CRP level categories (B), adjusting for pre-vaccination antibody/CMI response and additional covariates; both the outcome and TNF/IL-6 were standardized to facilitate cross-comparison. Standardized coefficients (β) and 95% confidence intervals for TNF, IL-6 and CRP (either the Medium vs. Low, or High vs. Low contrast) are presented, and significance is indicated by an asterisk and when the 95% confidence interval does not cross the red, dotted line

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Immunity & Ageing

ISSN: 1742-4933

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