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Fig. 5 | Immunity & Ageing

Fig. 5

From: Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells

Fig. 5

Causal mediation analysis to describe the relationship between frailty, IL-6 levels and the frequency of ILT2+CD57.+ Dim NK-cells with post-vaccination A/H3N2 antibody titres in older high-dose recipients. The association between the frailty index and IL-6 (β = 0.210) represents the unadjusted coefficient, estimated in older high-dose recipients from the 4-year trial (n = 289). Associations between IL-6 and NK-cell frequency (β = 0.243) and NK-cell frequency and post-vaccination antibody titres (β = 0.241) were estimated in the follow-up cohort (n = 63) and represent the unadjusted coefficient and the age, sex, site, baseline antibody titre and IL-6 adjusted coefficient, respectively. In the lower left, the proportion (95% confidence interval) that NK-cell frequency mediates the relationship between IL-6 and post-vaccination antibody titres is shown, and in the upper right, the total effect (ie. 0.148) and direct effect of IL-6 (ie. 0.089) is shown. All measures were standardized, while IL-6, NK-cell frequency and antibody titres were additionally natural-log transformed. Asterisks denote significance (***, p < 0.001; **, p < 0.01)

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Immunity & Ageing

ISSN: 1742-4933

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