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Table 3 The hormesis activity of natural compounds in vitro and in vivo in Alzheimer’s disease

From: Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases

Activity Compound Source Plant Model Treatment Remarks Reference
Alzheimer Cannflavin A Cannabis sativa PC12 cells 1 to 10 μM The low dose was effective [64]
  Blueberry   Mice 25 μM The blueberry inhibits behavioral deficits [65]
Gintonin Panax ginseng Mice 25, 50, or 100 mg/kg Gintonin improves memory dysfunctions [66]
Ginsenoside Rg1 Panax ginseng Mice 20 mg/kg Rg1 ameliorates memory impairment [67]
Curcumin Curcuma longa Mouse 160 ppm The low dose was effective [69]
Curcumin encapsulated PLGA nanoparticles (Cur-PLGA-NPs) Curcuma longa Rat 20 mg/kg Cur-PLGA-NPs improve learning and memory impairments [70]
Resveratrol Ribes nigrum Rat 25 μM Resveratrol reduces Aβ aggregation [71]
Resveratrol and catechin Ribes nigrum and Camellia sinensis PC-12 cells Catechin (50 μM), resveratrol (10 μM) Catechin is more effective [72]
Catechin Camellia sinensis Rat 5 g/L Catechin ameliorates cognitive deficits [73]