Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases

Immunity & Ageing

Table 3 The hormesis activity of natural compounds in vitro and in vivo in Alzheimer’s disease

Activity	Compound	Source Plant	Model	Treatment	Remarks	Reference
Alzheimer	Cannflavin A	Cannabis sativa	PC12 cells	1 to 10 μM	The low dose was effective	[64]
	Blueberry		Mice	25 μM	The blueberry inhibits behavioral deficits	[65]
	Gintonin	Panax ginseng	Mice	25, 50, or 100 mg/kg	Gintonin improves memory dysfunctions	[66]
	Ginsenoside Rg1	Panax ginseng	Mice	20 mg/kg	Rg1 ameliorates memory impairment	[67]
	Curcumin	Curcuma longa	Mouse	160 ppm	The low dose was effective	[69]
	Curcumin encapsulated PLGA nanoparticles (Cur-PLGA-NPs)	Curcuma longa	Rat	20 mg/kg	Cur-PLGA-NPs improve learning and memory impairments	[70]
	Resveratrol	Ribes nigrum	Rat	25 μM	Resveratrol reduces Aβ aggregation	[71]
	Resveratrol and catechin	Ribes nigrum and Camellia sinensis	PC-12 cells	Catechin (50 μM), resveratrol (10 μM)	Catechin is more effective	[72]
	Catechin	Camellia sinensis	Rat	5 g/L	Catechin ameliorates cognitive deficits	[73]

ISSN: 1742-4933