Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases

Sahebnasagh, Adeleh; Eghbali, Samira; Saghafi, Fatemeh; Sureda, Antoni; Avan, Razieh

doi:10.1186/s12979-022-00292-x

Immunity & Ageing

Table 4 The hormesis activity of natural compounds in vitro and in vivo in PD

From: Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases

Activity	Compound	Source Plant	Model	Treatment	Remarks	Reference
Parkinson	Resveratrol	Ribes nigrum	Rat	10, 20 and 40 mg/kg	Resveratrol exerts a neuroprotective effect	[79]
	Resveratrol	Ribes nigrum	Rat	100 μM	Resveratrol exerts a neuroprotective effect	[80]
	Resveratrol	Ribes nigrum	Rat	20 mg/kg	Resveratrol exerts the protective activity	[81]
	Epigallocatechin 3-gallate	Camellia sinensis	Mice	0.1–10 μM	Epigallocatechin 3-gallate exerts neuroprotective effects	[82]
	Caffeine	Camellia sinensis	Rat	10 mg/kg and 20 mg/kg	The low dose was effective	[83]
	Caffeine	Camellia sinensis	Rat	60-80 mg/kg	Caffeine exerts protective activity	[84]
	Mulberry fruit	Morus alba	Mouse	500 mg/kg	Mulberry fruit exhibits neuroprotective activity	[86]
	Tubers	Dioscorea alata	Mouse	100–300 μg/mL	The low dose was effective.	[88]
	Ginsenoside Rg1	Panax ginseng	Mouse	10 and 50 μM	Ginsenoside Rb1 treats of PD	[90]
	Quercetin	Crocus sativus	Rat	50 mg/kg	Quercetinexhibits protective activity	[91]
	Quercetin	Crocus sativus	Mouse	0.3–30 μM	Quercetin improves behavioral deficits	[92]
	Hydroxytyrosol and oleuropeinaglycone	Olea europaea	Mouse	Hydroxytyrosol (250 μg/mL) oleuropeinaglycone (500 μg/mL)	Hydroxytyrosol was more effective	[95]
	Cannabinoids	Cannabis sativa	Rat	3 mg/kg	Cannabinoids exerts neuroprotection activity	[98]
	Allicin	Allium sativum	PC-12 cells	50 μM	Allicin exerts protective action	[99]
	Curcumin	Curcuma longa	Rat	40 mg/kg	Curcumin exhibits protective activity	[100]
	Curcumin, naringenin, quercetin and fisetin	Curcuma longa, Citrus aurantium, Crocus sativus	Rat	50 mg/kg	Quercetin and fisetin exhibit neuroprotection effects	[101]
	Panaxatriol saponins	Panax notoginseng	PC12 cells	0.12 mg/mL	The low dose was effective.	[5]
	Berberine	Berberis vulgaris	PC12 cells	0.3-20 μM	Berberine improves behavior movement deficiency	[103]

Back to article page

ISSN: 1742-4933

Contact us

General enquiries: journalsubmissions@springernature.com