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Table 5 The hormesis activity of natural compounds in vivo in HD

From: Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases

Activity Compound Source Plant Model Treatment Remarks Reference
Huntingto Protopanaxtriol Panax ginseng Rat 5,10 and 20 mg/kg Protopanaxtriol improves body weight and behavior [107]
Korean red ginseng Panax ginseng Mice 50, 100, and 250 mg/kg Korean red ginseng inhibits Huntington’s symptoms [108]
Fisetin and resveratrol Ribes nigrum Mice 10 μM Both compounds treat of HD [109]
  Calendula officinalis Rat 100 and 200 mg/kg Calendula officinalis indicates protective effect [110]
Thymoquinone and solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) Nigella sativa Rat TQ (80 mg/kg), TQ-SLNs (10 mg/kg) The low dose of TQ-SLNs is highly effective [112]