Table 5 The hormesis activity of natural compounds in vivo in HD
From: Neurohormetic phytochemicals in the pathogenesis of neurodegenerative diseases
Activity | Compound | Source Plant | Model | Treatment | Remarks | Reference |
|---|---|---|---|---|---|---|
Huntingto | Protopanaxtriol | Panax ginseng | Rat | 5,10 and 20 mg/kg | Protopanaxtriol improves body weight and behavior | [107] |
Korean red ginseng | Panax ginseng | Mice | 50, 100, and 250 mg/kg | Korean red ginseng inhibits Huntington’s symptoms | [108] | |
Fisetin and resveratrol | Ribes nigrum | Mice | 10 μM | Both compounds treat of HD | [109] | |
|  | Calendula officinalis | Rat | 100 and 200 mg/kg | Calendula officinalis indicates protective effect | [110] | |
Thymoquinone and solid lipid nanoparticles encapsulated thymoquinone (TQ-SLNs) | Nigella sativa | Rat | TQ (80 mg/kg), TQ-SLNs (10 mg/kg) | The low dose of TQ-SLNs is highly effective | [112] |