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Fig. 1 | Immunity & Ageing

Fig. 1

From: Excessive IL-15 promotes cytotoxic CD4 + CD28− T cell-mediated renal injury in lupus nephritis

Fig. 1

Expanded CD4 + CD28− T cells in the circulation of SLE patients with nephritis exhibit innate-like function

(A) Representative flow cytometry dot plots showing the gating strategy used to define CD4 + CD28− T cells

(B) A summary of the CD4 + CD28− T cell population in 21 healthy controls and 43 patients with SLE (5.03 ± 0.95% vs. 14.09 ± 2.12%, P = 0.0051). Each circle represents one individual. Horizontal bars indicate the mean

(C) A correlation was found between the CD4 + CD28−T cell population and the SLE duration

(D) The number of CD4 + CD28−T cells in 33 nephritic SLE patients was larger than that in 10 SLE patients without nephritis

(E) Analysis of the expression levels of NKG2D and the chemokine receptor CX3CR1, integrin CD11a, CD49d on CD4 + CD28− and CD4 + CD28 + T cells from PBMCs of 10 healthy controls and 10 SLE patients. *P < 0.05; **P < 0.01; ***P < 0.001

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