Fig. 1

CRP increases with frailty. (A) CRP plasma levels are shown to be significantly higher in all Frail (Fr, n = 65) compared to nFr (n = 64) subjects (***p < 0.001). CRP plasma levels were analyzed according to gender separation; in (B) CRP plasma levels increase in Fr male (n = 33) compared to nFr male (n = 32) subjects (*p < 0.05). In (C) are reported data from Fr female (n = 32) compared to nFr female (n = 32) subjects, a statistically significant increase is observed in Fr vs. nFr subjects (**p < 0.01). Statistical analysis was performed using the Mann–Whitney U test (non-parametric) for comparisons between two groups using GraphPad Prism8 software. A p < 0.05 was considered statistically significant