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Fig. 5 | Immunity & Ageing

Fig. 5

From: Inflammation and cell-to-cell communication, two related aspects in frailty

Fig. 5

The inflammatory markers highlight an increase in TLR2 + /calcein + lEVs and TLR4 + /calcein + lEVs in Fr subjects. A TLR2 + /calcein + lEVs show significantly higher plasma concentration in all Fr (n = 20) compared to nFr (n = 20) subjects (*p < 0.05). B A significant increase (*p < 0.05) was reported in male Fr (n = 7) compared to Fit (n = 11) subjects. C No differences were reported in the female Fr (n = 13) versus nFr (n = 9) group. D TLR4 + /calcein + lEVs show significantly increase higher plasma concentration in all Fr (n = 20) compared to nFr (n = 20) subjects (***p < 0.001). E A significant increase (***p < 0.001) was reported in male Fr (n = 7) compared to nFr (n = 11) subjects. F The female Fr (n = 13) group shows a significant increase (**p < 0.01) in TLR4 + /calcein + lEVs versus nFr (n = 9). Statistical analysis was performed using the Mann–Whitney U test (non-parametric) for comparisons between two groups using GraphPad Prism8 software. A p < 0.05 was considered statistically significant

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