Fig. 7
From: Inflammation and cell-to-cell communication, two related aspects in frailty
CD221 + /calcein + and IL-6R + /calcein + lEVs increase in Fr subjects. A CD221 + /calcein + lEVs show significantly higher plasma concentration in all Fr (n = 20) compared to nFr (n = 20) subjects (***p < 0.001). B A significant increase (***p < 0.001) was reported in male Fr (n = 7) compared to nFr (n = 11) subjects. C The female Fr (n = 13) group shows a significant increase (**p < 0.01) in CD221 + /calcein + lEVs versus nFr (n = 9). D IL-6R + /calcein + lEVs show significantly higher plasma concentration in all Fr (n = 20) compared to nFr (n = 20) subjects (***p < 0.001). E A significant increase (**p < 0.01) was reported in male Fr (n = 7) compared to nFr (n = 11) subjects. F The female Fr (n = 13) group shows a significant increase (*p < 0.05) in IL-6R + /calcein + lEVs versus nFr (n = 9). Statistical analysis was performed using the Mann–Whitney U test (non-parametric) for comparisons between two groups using GraphPad Prism8 software. A p < 0.05 was considered statistically significant