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Fig. 3 | Immunity & Ageing

Fig. 3

From: Cytomegalovirus infection reduced CD70 expression, signaling and expansion of viral specific memory CD8+ T cells in healthy human adults

Fig. 3

Reduced expression of CD70 in CMV-specific CD8+ TCM cells. A Gene Set Enrichment Analysis (GSEA) identified genes in pathway negatively regulating MAPK activity which is enriched in CMV-specific TCM cells. B Heatmap showing genes in pathway negatively regulating MAPK activity differentially express between CMV-specific and IAV-specific TCM cells from duplicated microarray experiments. C The expression level of CD70 in CMV- and IAV-specific TCM cells analyzed by RT-PCR. D Representative flow cytometry plots showing gating on CD70 expression in CMV- and IAV-specific CD8+ T cells. (E) Frequencies of CD70+ cells in CMV- and IAV-specific TN (N=32) and TCM (N=33) cells from CMV IgG positive healthy adults. * Indicates P < 0.05

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