Fig. 7

Stable reduced expression of CD70 in CMV-specific T_CM compared to IAV-specific T_CM with age. A Age-related changes in CMV- and IAV-specific CD8⁺ T cells in CMV IgG⁺ and IgG^- donors. The p-value for correlation between CMV-specific cells and age is 0.066. The difference between the age-adjusted average percentage of CMV-specific and IAV-specific cells in IgG⁺ donors is significant (p=0.0005). Similarly, the difference of age-adjusted average percentage of CMV-specific cells between IgG⁺ and IgG^- donors is significant (p=0.0012). B CD70 expression in CMV- and IAV-specific T_CM in CMV IgG⁺ subjects. A cohort of 45 healthy CMV IgG⁺ subjects aged from the 20s to 80s was analyzed via tetramer staining by flow cytometry