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Fig. 2 | Immunity & Ageing

Fig. 2

From: Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats

Fig. 2

Atorvastatin regulated intestinal retinoic acid (RA) metabolism and storage (A-C) Quantification of blood glucose, glycosylated serum protein and insulin concentrations in the serum of each group of rats (n = 10 per group). (D-F) Retinoic acid (RA), retinol (ROH) and retinyl esters (RE) in the small intestine were quantified by LC‒MS in the three groups (n = 4 per group). (G) Quantification of Rdh7 mRNA in small intestinal tissues by qPCR in the three groups (n = 5 per group). (H) Immunofluorescence of small intestine tissues in the three groups (n = 5 per group). Immunofluorescence of Rdh7 (red) in small intestinal tissue; DAPI was used to visualize nuclei (blue). Data are presented as the mean ± SEM. Statistical analyses were performed using a repeated-measure ANOVA with Sidak’s multiple comparisons test (A, B, C) or a one-way ANOVA with Tukey’s multiple comparison test (D, E, F, G). *P < 0.05, **P < 0.01, ***P < 0.001. C: control group, L: low-dose atorvastatin group, H: high-dose atorvastatin group

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