Fig. 2

CD8+ T cells cytotoxic activity increases with age in the EM. Purified EM CD8+ T cells (or CD103+ or CD103− as indicated) were co-cultured with CFSE-stained allogeneic blood CD4+ T cells as target cells (ratio 1:1). Cytotoxicity was calculated by measuring the average number of dead target cells over the first 4 h. Graph represents the fold change in number of dead target cells in CD8+ T cells + target cells cultures compared to target cells alone. A Correlation between CD8+ T cells cytotoxicity and age from the entire study population (n = 53). B Correlation between CD8+ T cells cytotoxicity and age after separating pre- (left; n = 22) and post-menopausal cells (right; n = 31) women. C Correlation between CD103 + CD8+ T cells (left) or CD103-CD8+ T cells (right) cytotoxicity and age from the entire study population (n = 18). D Correlation between the difference of matched CD103+ and CD103-CD8+ T cells cytotoxicity and age (n = 18). Each dot represents a single patient. Spearman test