Fig. 2

Survival curves survival of patients with different levels of n-cfDNA integrity, NE and sCD163. Each variable was categorized into tertiles as follows: for n-cfDNA, Alu247/115 ≤ 0.32 (tertile 1), 0.32 < Alu247/115 ≤ 0.62 (tertile 2), Alu247/115 > 0.62 (tertile 3); for NE, ≤ 74.0 ng/ml (tertile 1), 74 ng/ml < NE ≤ 146.7 ng/ml (tertile 2), NE > 146.7 ng/ml (tertile 3); for sCD163, ≤ 491 ng/ml (tertile 1), 491 ng/ml < sCD163 ≤ 811 ng/ml (tertile 2), sCD163 > 811 ng/ml (tertile 3). A. Upper graph: Kaplan-Meier survival estimates of patients with categorical values (tertiles) of n-cfDNA integrity index (Alu 247/115). Log-rank test for equality of survivor functions: p-value =0.039. Center: Kaplan-Meier survival estimates of patients with categorical values (tertiles) of NE. Log-rank test for equality of survivor functions: p-value = 0.441. Bottom: Kaplan-Meier survival estimates of patients with different categorical values (tertiles) of sCD163. Log-rank test for equality of survivor functions: p-value =0.020. B. Upper graph: Survival curves for different categorical values (tertiles) of cfDNA integrity index (Alu 247/115) adjusted for the covariates from the Cox proportional hazard “multivariate model 3”. Center: Survival curves for different categorical values (tertiles) of NE adjusted for the covariates from the Cox proportional hazard “multivariate model 3”. Bottom: Survival curves for different categorical values (tertiles) of sCD163 adjusted for the covariates from the Cox proportional hazard “multivariate model 3”