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Table 3 Markers of cell damage, neutrophil and macrophage activation in COVID-19 patients with and without detectable SARS-CoV-2 RNAemia (Mann-Whitney independent samples test)

From: Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients

 

Total

SARS-CoV-2 RNAemia

(negative plasma samples, n=126)

SARS-CoV-2 RNAemia

(positive plasma samples, n=30)

p-value

Alu 115 (n-cfDNA) pg/ÎĽla, median(IQR)

361.67 (154.23-1041.85)

318.68 (145.52-904.82)

801.60 (382.90-1479.74)

0.005

Alu 247 (n-cfDNA) pg/ÎĽla, median(IQR)

136.86 (52.62-519.81)

113.15 (46.52-417.98)

296.05 (74.86-931.76)

0.055

Alu 247/115 (n-cfDNA integrity), median(IQR)

0.44 (0.27-0.69)

0.46 (0.28-0.68)

0.32 (0.23-0.73)

0.380

MT-CO3 (mt-cfDNA ) pg/ÎĽlb, median(IQR)

2.380 (1.12-5.22)

1.985 (0.98-4.65)

4.26 (2.01-8.26)

0.002

NE ng/ml , median(IQR)

105.1 (56.50-172.95)

93.95 (48.60-154.50)

154.00 (100.20-234.00)

<0.001

LL-37 ng/mL, median(IQR)

39.0 (26.8-55.6)

39.3 (27.4-58.0)

34.05 (24.9-48.8)

0.501

sCD163, median(IQR)

647.60 (441.00-951.9000)

644.00 (375.00-940.45)

676.00 (541.80-1161.50)

0.149

  1. aAbsolute equivalent amount of genomic DNA/ÎĽl in the extracted sample. bAbsolute equivalent amount of the template (mitochondrial) DNA in the extracted sample. Font in bold: significant p-value
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Immunity & Ageing

ISSN: 1742-4933

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