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Table 4 Cox proportional hazard ratios (HR) for survival based on different multivariate models

From: Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients

 

Multivariate model

(1)

Multivariate model

(2)

Multivariate model

(3)

 

HR (95%CI)

p-value

HR (95%CI)

p-value

HR (95%CI)

p-value

n-cfDNA integrity tertiles

 3 (Alu247/115 > 0.625)

1

 

1

 

1

 

 2 (0.321 < Alu247/115 ≤ 0.625)

1.55 (0.64-3.77)

0.332

1.56 (0.64-3.79)

0.328

1.72 (0.70-4.24)

0.241

 1 (Alu247/115 < 0.321)

3.74 (1.61-8.74)

0.002

4.79 (2.00-11.48)

<0.001

4.14 (1.71-10.02)

0.002

Neutrophil elastase tertiles

 1 (NE ≤ 74.0)

1

 

1

 

1

 

 2 (74 < NE ≤ 146.7)

0.87 (0.39-1.96)

0.734

1.47 (0.61-3.50)

0.390

1.27 (0.52-3.11)

0.594

 3 (NE > 146.7)

1.77 (0.78-3.99)

0.171

3.88 (1.53-9.86)

0.004

2.94 (1.10-7.89)

0.032

sCD163 tertiles

 1 (sCD163 ≤ 491)

1

 

1

 

1

 

 2 (491 < sCD163 ≤ 811)

3.06 (1.32-7.10)

0.009

2.78 (1.15-6.72)

0.023

2.60 (1.09-6.24)

0.032

 3 (sCD163 > 811)

2.34 (0.99-5.50)

0.052

2.40 (0.98-5.89)

0.056

2.25 (0.91-5.52)

0.078

Sex

 Male

1

 

1

 

1

 

 Female

1.11 (0.60-2.03)

0.739

1.20 (0.63-2.28)

0.587

1.17 (0.61-2.23)

0.637

Age

1.10 (1.04-1.16)

0.001

1.09 (1.03-1.15)

0.004

1.08 (1.02-1.15)

0.008

Stroke

      

 No

  

1

 

1

 

 Yes

  

1.51 (0.66-3.44)

0.329

1.44 (0.62-3.34)

0.398

COPD

      

 No

  

1

 

1

 

 Yes

  

4.76 (2.07-10.94)

<0.001

4.47 (1.90-10.48)

0.001

CKD

      

 No

  

1

 

1

 

 Yes

  

0.89 (0.44-1.81)

0.745

0.85 (0.41-1.74)

0.656

CFS

      

 Ref. Cat. (0-3)

  

1

 

1

 

 1 (4-7)

  

4.92 (1.10-22.01)

0.037

4.63 (1.04-20.65)

0.044

 2 (8-9)

  

4.53 (0.98-20.93)

0.053

4.32 (0.94-19.77)

0.059

SARS-CoV-2 RNAemia

      

 Negative

    

1

 

 Positive

    

1.91 (1.00-3.65)

0.051

  1. Font in bold: significant p-value