Fig. 3
From: MicroRNAs: a crossroad that connects obesity to immunity and aging
miRs play an important role in the progression of cellular senescence.
miR-34 family directly affects the cell cycle, whereas miR-125b and miR-504 target p53, which is associated with cell cycle progression. Additionally, both the miR-34 family and miR-155 are associated with telomere shortening. Increased levels of miR-335 increase SASP-related factors. Several pro-inflammatory markers are associated with inflammation-aging, which is markedly decreased by SIRT1 and miR-204 upregulates SIRT-1 expression. miR-146a and miR-181a are directly associated with cellular senescence. All these events collectively pave the way for aging and suggest a crucial role of miRs in cellular senescence.