Association of leukocyte mitochondrial DNA copy number with longitudinal C-reactive protein levels and survival in older adults: a cohort study

Table 3 Association between estimated high-sensitivity C-reactive protein trajectory and risk of mortality^a

	All			Excluding participants (n = 82) with hs-CRP > 10 mg/L during follow-up			Excluding participants (n = 319) with hs-CRP > 3 mg/L during follow-up
Trajectory feature	Hazard ratio^b	95% CI	P	Hazard ratio^b	95% CI	P	Hazard ratio^b	95% CI	P
Instantaneous hs-CRP level (mg/L)
Unadjusted	1.36	1.27 to 1.46	< .001	1.37	1.25 to 1.48	< .001	1.37	1.20 to 1.54	< .001
Multivariable adjusted^c	1.22	1.14 to 1.30	< .001	1.21	1.11 to 1.31	< .001	1.19	1.06 to 1.31	< .001

^aHs-CRP, high-sensitivity C-reactive protein
^bHazard ratio per 1 standard deviation increase in hs-CRP levels
^cAdjusted for age, sex, educational level, smoking status, obesity (BMI), dyslipidemia (serum triglycerides, HDL cholesterol, LDL cholesterol), hypertension, cardiometabolic diseases (diabetes mellitus, stroke, cardiovascular disease), lung disease, and chronic kidney disease

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