Fig. 2
From: Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice
HFD induces obesity and metabolic dysfunction in adult and aged mice. (A) Study design for cohort 2: mice aged 5 wk and 1 yr were fed high-fat diet (HFD) or standard diet (SD) for 14 wk; SD adult in teal, HFD adult in red, SD aged in blue, and HFD aged in orange. (B) Terminal body weights at study endpoint, ***P < 0.001, ****P < 0.0001 by one-way ANOVA. (C) Terminal body composition by percent lean and fat mass, **P < 0.01, ***P < 0.001, ****P < 0.0001 by Kruskal–Wallis for non-normally distributed lean mass and by one-way ANOVA for fat mass. (D) Terminal glucose tolerance test, P < 0.05 by two-way ANOVA (*, #, $, ^; shown in legend); area under the curve for each experimental group, ****P < 0.0001 by one-way ANOVA. n = 10 per group for all measures. Data are presented as mean ± standard deviation