Fig. 3From: Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individualsEV inflammatory proteins are associated with frailty, sex, and race. Plasma EVs from individuals in the frailty cohort were lysed and analyzed in a multiplex proximity extension assay (n = 177). Normalized protein levels (NPL, which is in a log2 scale) are shown. Linear regression was used to determine the relationship between EV protein levels and frailty status, accounting for sex, race, and poverty status. A EV inflammatory proteins that had a significant relationship between frailty status and race are plotted. The plots show the linear regression values ± standard error of the estimated values. B uPA had a significant three-way interaction with frailty status, race, and poverty status. C CCL28 and CXCL1 had a significant interaction with frailty and sex. AA = African American; NPL = normalized protein levelBack to article page