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Fig. 3 | Immunity & Ageing

Fig. 3

From: Mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals

Fig. 3

EV inflammatory proteins are associated with frailty, sex, and race. Plasma EVs from individuals in the frailty cohort were lysed and analyzed in a multiplex proximity extension assay (n = 177). Normalized protein levels (NPL, which is in a log2 scale) are shown. Linear regression was used to determine the relationship between EV protein levels and frailty status, accounting for sex, race, and poverty status. A EV inflammatory proteins that had a significant relationship between frailty status and race are plotted. The plots show the linear regression values ± standard error of the estimated values. B uPA had a significant three-way interaction with frailty status, race, and poverty status. C CCL28 and CXCL1 had a significant interaction with frailty and sex. AA = African American; NPL = normalized protein level

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