Table 2 Correlation of epidermal biophysical properties with serum cytokine levels
Crude Correlation | Stratum Corneum Hydration | Transepidermal Water Loss | Skin Surface pH | ||||
|---|---|---|---|---|---|---|---|
Left Forearm | Right Shin | Left Forearm | Right Shin | Left Forearm | Right Shin | ||
IL-1α | Males | R = -0.2581, p = 0.0185 | R = -0.02294, NS | R = -0.1980, NS | R = 0.1682, NS | R = 0.04047, NS | R = -0.1034, NS |
Females | R = -0.2363, p = 0.0018 | R = -0.1767, p = 0.0204 | R = 0.03520, NS | R = 0.06082, NS | R = 0.06915, NS | R = 0.02276, NS | |
Overall | R = -0.2300, p = 0.002 | R = -0.1102, p = 0.0791 | R = -0.02591, NS | R = 0.1041, NS | R = 0.04531, NS | R = -0.03556, NS | |
IL-1β | Males | R = -0.2094, p = 0.0575 | R = -0.1004, NS | R = -0.1208, NS | R = 0.1750, NS | R = -0.1687, NS | R = -0.2339, p = 0.0333 |
Females | R = -0.2626, p = 0.0005 | R = -0.2339, p = 0.0020 | R = 0.01403, NS | R = 0.02684, NS | R = 0.03418, NS | R = 0.02138, NS | |
Overall | R = -0.2358, p = 0.0001 | R = -0.1811, p = 0.0037 | R = -0.01860, NS | R = 0.08090, NS | R = -0.03080, NS | R = -0.06734, NS | |
IL-6 | Males | R = -0.2026, p = 0.0662 | R = -0.09027, NS | R = -0.08329, NS | R = 0.1757, NS | R = -0.05662, NS | R = -0.1859, NS |
Females | R = -0.3273, p < 0.0001 | R = -0.2794, p = 0.0002 | R = 0.07693, NS | R = 0.1223, NS | R = 0.07651, NS | R = 0.02215, NS | |
Overall | R = -0.2547, p < 0.0001 | R = -0.1900, p = 0.0023 | R = 0.02729, NS | R = 0.1472, p = 0.0187 | R = 0.009841, NS | R = -0.07664, NS | |
TNFα | Males | R = -0.06558, NS | R = -0.06368, NS | R = 0.01172, NS | R = 0.1622, NS | R = -0.2270, p = 0.0391 | R = -0.2920, p = 0.0071 |
Females | R = -0.3171, p < 0.0001 | R = -0.3625, p < 0.0001 | R = 0.02069, NS | R = 0.05679, NS | R = 0.1079, NS | R = 0.09248, NS | |
Overall | R = -0.2025, p = 0.0011 | R = -0.2318, p = 0.0002 | R = 0.01563, NS | R = 0.1015, NS | R = -0.01750, NS | R = -0.06320, NS | |
IFNγ | Males | R = -0.2608, p = 0.0173 | R = -0.1574, NS | R = -0.1624, NS | R = 0.1696, NS | R = -0.05261, NS | R = -0.1110, NS |
Females | R = -0.1872, p = 0.0139 | R = -0.1431, p = 0.0611 | R = -0.05529, NS | R = 0.0007165, NS | R = 0.005025, NS | R = 0.001154, NS | |
Overall | R = -0.2050, p = 0.001 | R = -0.1449, p = 0.0206 | R = -0.07432, NS | R = 0.04781, NS | R = 0.002921, NS | R = -0.02499, NS | |
Age- and Sex-Adjusted Correlation | |||||||
IL-1α | R = -0.269, p < 0.0001 | R = -0.163, p = 0.009 | R = -0.035, p = 0.575 | R = 0.087, p = 0.166 | R = 0.063, p = 0.315 | R = -0.004, p = 0.944 | |
IL-1β | R = -0.244, p < 0.0001 | R = -0.189, p = 0.003 | R = -0.016, p = 0.798 | R = 0.084, p = 0.185 | R = -0.027, p = 0.664 | R = -0.068, p = 0.283 | |
IL-6 | R = -0.287, p < 0.0001 | R = -0.227, p < 0.0001 | R = 0.027, p = 0.672 | R = 0.140, p = 0.026 | R = 0.031, p = 0.622 | R = -0.051, p = 0.416 | |
TNFα | R = -0.191, p = 0.002 | R = -0.195, p = 0.002 | R = 0.035, p = 0.577 | R = 0.127, p = 0.044 | R = -0.013, p = 0.842 | R = -0.082, p = 0.192 | |
IFNγ | R = -0.198, p = 0.002 | R = -0.133, p = 0.034 | R = -0.070, p = 0.268 | R = 0.057, p = 0.363 | R = -0.009, p = 0.888 | R = -0.040, p = 0.530 | |