Table 5 PCA for proinflammatory cytokine secretion. Shown are PC score differences and Euclidean distance (in the space defined by PC1 and PC2) between treatments and control (untreated cells). We observed a cluster of adjuvants (NP + Mi + CpG, R848, MPLA, CpG, NP + Mi + R848, and LPS) that appear to be inducing the most proinflammatory cytokines
Adjuvants | PC1(Adjuv)-PC1(Media) | PC2(Adjuv)-PC2(Media) | Distance(PC1,PC2) |
|---|---|---|---|
CDN | 0.58 | 0 | 0.58 |
FLA-BS | 1.27 | −0.04 | 1.27 |
Micelles | 1.33 | 0.45 | 1.4 |
MDP | 1.58 | −0.19 | 1.59 |
NP + Mi + CDN | 1.7 | 0.76 | 1.86 |
NP | 2.33 | 0.69 | 2.43 |
NP + Mi + CpG | 3.64 | −0.04 | 3.64 |
R848 | 4.56 | −0.49 | 4.59 |
MPLA | 4.69 | 0.46 | 4.71 |
CpG | 4.88 | −0.51 | 4.91 |
NP + Mi + R848 | 4.89 | 0.59 | 4.92 |
LPS | 5.06 | 0.49 | 5.08 |