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Fig. 7 | Immunity & Ageing

Fig. 7

From: UGRP1-modulated MARCO+ alveolar macrophages contribute to age-related lung fibrosis

Fig. 7

Age-related expression levels of hUGRP1 and hMARCO. Lung samples of nonsmoking aged patients with bullous lung disease (≥ 60 years old, n = 11) and nonsmoking young patients with bullous lung disease (≤ 40 years old, n = 17) were detected by immunohistochemistry. A Expression levels of human UGRP1. The arrows indicate the UGPR1 positive cells. Scale bar, 50 μm. UGPR1+ cell numbers were counted and analyzed. Each symbol represents the average of 10 fields of vision (20 ×) from an individual sample. B Correlation analysis of UGRP1+ cells and age (n = 28). C Expression levels of human MARCO. The arrows indicate the MARCO positive cells. Scale bar, 25 μm. MARCO+ cell numbers were counted and analyzed. Each symbol represents the average of 10 fields of vision (40 ×) from an individual sample. Scale bar, 25 μm. D Correlation analysis of MARCO+ cells and age (n = 28). E Correlation analysis of UGRP1+ cells to MARCO+ cells in the lung tissue samples (n = 28). F Correlation analysis of the gene expression of UGRP1 to MARCO in the lung tissues by GTEx data using GEPIA2 software. The Pearson correlation coefficient was calculated (B, D, E and F). G Lung samples were detected by Masson Trichrome staining. Ashcroft scores were used to indicate the degree of fibrosis. Data are shown as the mean ± SEM. Comparisons by unpaired two-tailed Student’s t-test. *** p < 0.001, **** p < 0.0001

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