Outcomes | CRP β (CI) | sTNFR1 β (CI) | TNFα β (CI) | IL-6 β (CI) |
|---|
Cognition
|
Global cognition | -0.83 (-1.91, 0.25) |
-5.85 (-8.63, -3.08)
| -1.01 (-2.32, 0.31) | -0.87 (-2.36, 0.62) |
Working memory | -0.81 (-1.82, 0.20) |
-4.01 (-6.46, -1.56)
| -0.42 (-1.66, 0.82) | -0.67 (-1.94, 0.60) |
Semantic memory |
-0.96 (-1.92, -0.01)
|
-5.52 (-7.90, -3.13)
| -0.24 (-1.61, 1.13) | -0.86 (-2.37, 0.64) |
Perceptual speed |
-1.26 (-2.34, -0.19)
|
-5.47 (-8.03, -2.92)
| -0.81 (-2.14, 0.51) | -1.19 (-3.24, 0.86) |
Perceptual orientation |
-1.18 (-2.04, -0.32)
|
-2.95 (-5.25, -0.65)
|
-1.10 (-2.12, -0.08)
| -0.57 (-1.65, 0.51) |
Episodic memory | -0.50 (-1.59, 0.59) |
-4.93 (-7.92, -1.94)
| -0.91 (-2.27, 0.44) | -0.89 (-2.17, 0.39) |
Physical Function
|
Frailty a | 0.003 (-0.05, 0.05) |
0.15 (0.03, 0.27)
| -0.03 (-0.08, 0.02) | -0.01 (-0.07, 0.05) |
Grip strength |
-2.90 (-4.94, -0.86)
|
-9.69 (-15.86, -3.52)
| -0.60 (-2.77, 1.57) | -2.18 (-4.66, 0.30) |
Gait speed | -0.01 (-0.03, 0.003) |
-0.08 (-0.13, -0.03)
| -0.01 (-0.04, 0.01) | -0.01 (-0.03, 0.02) |
Motor gait b |
-0.02 (-0.05, -0.002)
|
-0.16 (-0.22, -0.10)
| -0.01 (-0.05, 0.02) | -0.02 (-0.05, 0.01) |
Motor composite score c |
-0.03 (-0.05, -0.01)
|
-0.18 (-0.23, -0.13)
| -0.02 (-0.04, 0.01) |
-0.03 (-0.06, -0.01)
|
- Abbreviations: CI = Confidence interval; CRP = C-Reactive protein; ccf-mtDNA = circulating cell-free mitochondrial DNA; IL-6 = interleukin-6; TNF⍺ = Tumor necrosis factor ⍺; sTNFR1 = soluble Tumor necrosis factor ⍺ receptor 1
- aFrailty is composite variable consisting of grip strength, timed walk, body mass index and fatigue. Larger values correspond to higher frailty
- bMotor gait is a z-standardized composite variable comprised of walking time, walking steps, turning time, and turning steps. Larger values correspond to less time and fewer steps to complete task
- cMotor composite score is calculated using the following items: Purdue Pegboard Test, Finger-tapping test, Time to cover 8 feet, Number of steps required to cover 8 feet, 360 degree turn time, Number of steps to complete a 360 degree turn, Leg stand, Toe stand, Grip strength, Pinch strength. Larger values correspond to better functionality
- Coefficients represent the difference in the cognitive and physical outcomes per one unit increase in the inflammatory marker on the log scale. Inflammatory variables were log-transformed. Generalized estimating equations (GEE) were used to estimate association between inflammatory markers and cognitive and physical outcomes. Each coefficient was estimated from a separate GEE model. All models were adjusted for baseline age, sex, race, and education. Bold indicates p < 0.05
