Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults

Table 6 Associations of ccf-mtDNA and peripheral inflammatory markers with mortality (N = 672)

	Individual model sets Adjusted Hazard Ratio of Death β (95% CI)	Model 2 Adjusted Hazard Ratio of Death β (95% CI)	Model 3 Adjusted Hazard Ratio of Death β (95% CI)
Short ccf-mtDNA	3.54 (1.02, 12.30)	2.21 (0.55, 8.90)	N/A
Long ccf-mtDNA	2.40 (0.19, 30.7)	N/A	1.93 (0.15, 24.49)
CRP	1.38 (0.84, 2.27)	1.08 (0.63, 1.84)	1.12 (0.66, 1.90)
sTNFR1	4.37 (1.19, 16.00)	3.86 (0.96, 15.54)	3.92 (0.95, 16.21)

Abbreviations: CI = Confidence interval; CRP = C-Reactive protein; ccf-mtDNA = circulating cell-free mitochondrial DNA; sTNFR1 = soluble Tumor necrosis factor ⍺ receptor 1
Coefficients represent that for each 1-unit increase in the predictor variable, the hazard of death changes by β times. Each row of coefficients in the Individual model set was estimated from a separate model and was adjusted for baseline age, sex, race, and education. Models 2 and 3 were adjusted for demographics, CRP, and sTNFR1, with inclusion of short ccf-mtDNA (Model 2) and long ccf-mtDNA (Model 3). Ccf-mtDNA variables and peripheral inflammatory variables were log-transformed and modeled as continuous variables. Cox proportional-hazards model was used to estimate the hazard ratios. Bold indicates p < 0.05

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