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Fig. 4 | Immunity & Ageing

Fig. 4

From: The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial

Fig. 4

Flow cytometry analysis of exhaustion markers. CD4 and CD8 T cells were analyzed for expression of exhaustion markers CD57 and PD-1 prior to and following 20 weeks of treatment with either placebo or metformin and fold change in mean fluorescent intensity (MFI) was calculated. CD4 T cells had reduced A) CD57 expression with metformin, while no differences in C) PD-1 expression were observed. CD8 T cells had no differences in B) CD57 expression, while there was a trending increased in D) PD-1 expression with metformin treatment. Statistical significance was calculated by t-test and significance set at p < 0.05

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