Fig. 5
From: The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial
Analysis of circulating markers of inflammation and aging. Circulating markers of inflammation, growth factors, and age-related factors were measured prior to and following 20 weeks of treatment with either placebo or metformin. Plasma A) IL-6, B) IL-8, C) IL-17A, D) TNFa, E) TNFRI, F) TNFRII, G) C-reactive protein, H) IGF-1, I) IGFBP-2, J) Osteopontin, and M) GDF-15 and serum K) MMP-2 and L) MMP-9 was measured and fold change was calculated. Statistical significance was calculated by t-test and significance set at p < 0.05