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Table 1 Participant demographics and characteristics at baseline and following 20 weeks of treatment

From: The effect of metformin on influenza vaccine responses in nondiabetic older adults: a pilot trial

 

Placebo

Metformin

Subjects

7

8

Age

74.71 ± 2.45

74.13 ± 2.42

Male

3, 43%

5, 63%

Number Comorbidities Per Subject (#)

2.57 ± 0.84

2.50 ± 0.65

Height (inches)

64.43 ± 2.09

66.73 ± 1.13

Baseline Weight (lbs)

159.43 ± 7.52

167.86 ± 12.23

End of Treatment Weight (lbs)

162.71 ± 8.24

164.18 ± 13.09

Baseline BMI (kg/m2)

27.31 ± 1.68

26.43 ± 1.47

End of Treatment BMI (kg/m2)

27.83 ± 1.74

25.80 ± 1.56

Baseline Rockwood Frailty Index

0.09 ± 0.007

0.08 ± 0.003

End of Treatment Rockwood Frailty Index

0.09 ± .005

0.09 ± 0.005

Baseline Fried Frailty Score

0.86 ± 0.26

0.75 ± 0.25

End of Treatment Fried Frailty Score

1.29 ± 0.29

0.75 ± 0.16

Baseline SPPB Score

11 ± 0.69

10.63 ± 0.71

End of Treatment SPPB Score

11.43 ± 0.30

11.43 ± 0.28

  1. Participants were treated with placebo or metformin for approximately 20 weeks. Frailty index was calculated via 40 items previously validated for influenza outcomes [44]. Fried Frailty score was calculated via standard 5 categories [45]. The validated short performance physical battery (SPPB) was also utilized [46]. Data presented as mean ± SEM and analyzed via t-test. No significant differences were observed between groups