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Fig. 4 | Immunity & Ageing

Fig. 4

From: Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice

Fig. 4

HA-VLP or HA-VLP-Cyt vaccination-induced antibody recognizes heterologous A/WSN, A/Cal and group 1 stalk domain. Immune sera were collected at 2 weeks after boost immunization with HA-VLP or HA-VLP-Cyt from young adult and aged BALB/c mice (n= 6/group). HA-VLP or HA-VLP-Cyt with vaccine dose 3 µg or 6 µg were inoculated intramuscularly in two doses at an interval of 3 weeks. IgG antibody responses to A/WSN (A, D), A/Cal (B, E), and group 1 stalk domain (C, F) were measured and quantified in 1:100 boost sera (G, H). Error bars indicate mean ± SEM. * p<0.05; ** p<0.01; *** p<0.001

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Immunity & Ageing

ISSN: 1742-4933

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