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Fig. 6 | Immunity & Ageing

Fig. 6

From: Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice

Fig. 6

GPI-cytokine incorporation into HA-VLP vaccine reduces lung virus load and enhances survival of aged mice. Body weight changes (A and C), survival (B) and lung virus titer (D) at day 6 after A/PR8 challenge. Aged BALB/c mice (n= 5/group) were prime-boost immunized with 1 µg (A, B) or 3 µg (C, D) of HA-VLP or HA-VLP-Cyt prior to A/PR8 virus infection (2 LD50, 103.36 EID50). The statistical significances were determined using One-way ANOVA and Turkey's multiple comparison test and indicated in *** P < 0.001. Error bars indicate mean ± SEM

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