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Fig. 7 | Immunity & Ageing

Fig. 7

From: Hemagglutinin virus-like particles incorporated with membrane-bound cytokine adjuvants provide protection against homologous and heterologous influenza virus challenge in aged mice

Fig. 7

Higher dose of HA-VLP-Cyt vaccine reduces lung virus load in aged mice against heterologous virus. Aged BALB/c (n= 3-6/group) (A-D) mice received prime-boost immunization with 1 µg (A, B) or 6 µg (C, D) of HA-VLP or HA-VLP-Cyt before A/WSN infection. Young mice (E-G) prime-boost immunization with 1 µg (E) or 3 µg (F, G) of HA-VLP or HA-VLP-Cyt before A/WSN infection. Body weight changes (A, C, E, F) and lung virus titers at day 7 (B) or at day 8 (D, G) after A/WSN challenge (2 LD50, 11.6 EID50 for A, B, E, F, and G; 1 LD50, 5.8 EID50 for C and D). Error bars indicate mean ± SEM. The statistical significances were determined using One-way ANOVA and Turkey's multiple comparison test and indicated in ** P < 0.01; *** P < 0.001

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Immunity & Ageing

ISSN: 1742-4933

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