Skip to main content
Fig. 3 | Immunity & Ageing

Fig. 3

From: Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model

Fig. 3

Unaltered number of macrophages in male GlaKO DRG supported by the no chemoattractant effect of Gb3 or Lyso-Gb3. A Representative images of DRG stained for anti-IBA1. Scale bar 50 µm. B Quantification of DRG macrophages. 28 weeks wt mice n = 6, GlaKO mice n = 7, 57 weeks wt mice (n = 6), GlaKO mice (n = 8). Statistical significance was assessed using Kruskal–Wallis test followed by pairwise comparisons using Wilcoxon rank sum exact test and Bonferroni correction. *p < 0.05. C Representative images of migrated BV-2 cells using the transwell assay, in vitro. Scale bar 100 µm. D In line with the in vivo data, 1 µM Lyso-Gb3 or 1 µM Gb3 did not significantly increase cell migration of BV-2 cells (0.1% DMSO as vehicle). Wells per condition n = 3. Statistical significance was assessed using Kruskal–Wallis test

Back to article page