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  1. There is an established consensus that it is primarily the adaptive arm of immunity, and the T cell subset in particular, that is most susceptible to the deleterious changes with age known as “immunosenescence...

    Authors: Ludmila Müller, Tamas Fülöp and Graham Pawelec

    Citation: Immunity & Ageing 2013 10:12

    Content type: Review

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  2. The age-related changes of immune system functions are complex phenomena incompletely understood. The acquired immune system shows a functional decline in ability to respond to new pathogens during aging, wher...

    Authors: Fabiola Olivieri, Maria Rita Rippo, Francesco Prattichizzo, Lucia Babini, Laura Graciotti, Rina Recchioni and Antonio Domenico Procopio

    Citation: Immunity & Ageing 2013 10:11

    Content type: Review

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  3. It has now ascertained that the clinical manifestations of liver disease in the elderly population reflect both the cumulative effects of longevity on the liver and the generalized senescence of the organism a...

    Authors: Fabio Grizzi, Giuseppe Di Caro, Luigi Laghi, Paul Hermonat, Paolo Mazzola, Diane D Nguyen, Saba Radhi, Jose A Figueroa, Everardo Cobos, Giorgio Annoni and Maurizio Chiriva-Internati

    Citation: Immunity & Ageing 2013 10:9

    Content type: Review

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  4. It is now commonly accepted that chronic inflammation associated with obesity during aging induces insulin resistance in the liver. In the present study, we investigated whether the improvement in insulin sens...

    Authors: Leandro Pereira de Moura, Luciana Santos Souza Pauli, Dennys Esper Cintra, Claudio Teodoro de Souza, Adelino Sanchez Ramos da Silva, Rodolfo Marinho, Maria Alice Rostom de Melo, Eduardo Rochete Ropelle and José Rodrigo Pauli

    Citation: Immunity & Ageing 2013 10:8

    Content type: Research

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  5. The research literature has documented age-related increases in genetic damage, including oxidative DNA damage, in human T lymphocytes, in vitro and ex vivo. Such damage has the potential to interfere with the ab...

    Authors: Shiva Marthandan, Paul Hyland, Graham Pawelec and Yvonne Barnett

    Citation: Immunity & Ageing 2013 10:7

    Content type: Research

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  6. Neurodegenerative disorders such Alzheimer's disease (AD) are often characterized by senile plaques and neurofibrillary tangle. In addition, reactive astrogliosis, microglia activation and a chronic inflammati...

    Authors: Elisa Porcellini, Manuela Ianni, Ilaria Carbone, Massimo Franceschi and Federico Licastro

    Citation: Immunity & Ageing 2013 10:6

    Content type: Research

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  7. Advanced age results in crucial alterations of the innate and adaptive immune system leading to functional defects resulting in infection and chronic diseases. Toll-like receptors (TLR) recognize pathogenic st...

    Authors: Peter Uciechowski, Eva Maria Oellig, Erminia Mariani, Marco Malavolta, Eugenio Mocchegiani and Lothar Rink

    Citation: Immunity & Ageing 2013 10:4

    Content type: Research

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  8. Aging is considered an important independent risk factor for atherosclerosis. Down syndrome people (DS) display an accelerated aging process compared to healthy subjects, anyway they are relatively resistant t...

    Authors: Elena Vianello, Giada Dogliotti, Elena Dozio and Massimiliano Marco Corsi Romanelli

    Citation: Immunity & Ageing 2013 10:2

    Content type: Short report

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  9. Multiple Sclerosis (MS) is a multi-factorial disease, where a single biomarker unlikely can provide comprehensive information. Moreover, due to the non-linearity of biomarkers, traditional statistic is both un...

    Authors: Maira Gironi, Marina Saresella, Marco Rovaris, Matilde Vaghi, Raffaello Nemni, Mario Clerici and Enzo Grossi

    Citation: Immunity & Ageing 2013 10:1

    Content type: Research

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  10. Virus-specific memory CD8+ T cells persist long after infection is resolved and are important for mediating recall responses to secondary infection. Although the number of memory T cells remains relatively consta...

    Authors: Lisa M Connor, Jacob E Kohlmeier, Lynn Ryan, Alan D Roberts, Tres Cookenham, Marcia A Blackman and David L Woodland

    Citation: Immunity & Ageing 2012 9:28

    Content type: Research

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    The Erratum to this article has been published in Immunity & Ageing 2013 10:40

  11. Cytokines regulated by the inflammasome pathway have been extensively implicated in various age-related immune pathologies. We set out to elucidate the contribution of the nod-like receptor protein 3 (NLRP3) i...

    Authors: Alejandro Ramirez, Vijay Rathinam, Katherine A Fitzgerald, Douglas T Golenbock and Anuja Mathew

    Citation: Immunity & Ageing 2012 9:27

    Content type: Short report

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  12. Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impac...

    Authors: Annibale Alessandro Puca, Albino Carrizzo, Anna Ferrario, Francesco Villa and Carmine Vecchione

    Citation: Immunity & Ageing 2012 9:26

    Content type: Review

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  13. Questions remain about whether inflammation is a cause, consequence, or coincidence of aging. The purpose of this study was to define baseline immunological characteristics from blood to develop a model in rhe...

    Authors: Elizabeth S Didier, Chie Sugimoto, Lisa C Bowers, Imtiaz A Khan and Marcelo J Kuroda

    Citation: Immunity & Ageing 2012 9:25

    Content type: Research

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  14. The control of human health and diseases in the elderly population is becoming a challenge, since mean age and life expectation are progressively increasing as well as chronic degenerative diseases. These diso...

    Authors: Anna Maria Berghella, Ida Contasta, Tiziana Del Beato and Patrizia Pellegrini

    Citation: Immunity & Ageing 2012 9:24

    Content type: Hypothesis

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  15. Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases ...

    Authors: Rafael Solana, Raquel Tarazona, Allison E Aiello, Arne N Akbar, Victor Appay, Mark Beswick, Jos A Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp, Sheila Govind, Beatrix Grubeck-Loebenstein…

    Citation: Immunity & Ageing 2012 9:23

    Content type: Review

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  16. Thrombolytic therapy (TT) for acute ischemic stroke (AIS) can provoke bleeding’s complication depending on the ischemic lesion (IL) dimension. Inflammation involved in the setting of acute ischaemic stroke, is...

    Authors: Aliaksei Kisialiou, Giordana Pelone, Albino Carrizzo, Giovanni Grillea, Valentina Trimarco, Marina Marino, Michelangelo Bartolo, Alessandro Marco De Nunzio, Rodolfo Grella, Alessandro Landolfi, Annibale Puca, Claudio Colonnese and Carmine Vecchione

    Citation: Immunity & Ageing 2012 9:22

    Content type: Research

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  17. Respiratory Syncytial Virus (RSV) causes significant disease in the elderly, in part, because immunosenescence impairs protective immune responses to infection in this population. Despite previous and current ...

    Authors: Anu Cherukuri, Kate L Stokes, Kathryn Patton, Howard Kuo, Kaori Sakamoto, Stacie Lambert, Elizabeth Stillman, Martin L Moore and Sujin Lee

    Citation: Immunity & Ageing 2012 9:21

    Content type: Research

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  18. Alzheimer Disease (AD) is the most common neurodegenerative disorder worldwide, and account for 60% to 70% of all cases of progressive cognitive impairment in elderly patients. At the microscopic level distinc...

    Authors: Silvia Catricala, Mauro Torti and Giovanni Ricevuti

    Citation: Immunity & Ageing 2012 9:20

    Content type: Review

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  19. End-stage renal disease (ESRD) patients treated with renal replacement therapy (RRT) have premature immunologically aged T cells which may underlie uremia-associated immune dysfunction. The aim of this study w...

    Authors: Ruud WJ Meijers, Nicolle HR Litjens, Elly A de Wit, Anton W Langerak, Ashley van der Spek, Carla C Baan, Willem Weimar and Michiel GH Betjes

    Citation: Immunity & Ageing 2012 9:19

    Content type: Research

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  20. Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor...

    Authors: Sijia Chen, Anton JM de Craen, Yotam Raz, Evelyna Derhovanessian, Ann Vossen CTM, Rudi Westendorp GJ, Graham Pawelec and Andrea B Maier

    Citation: Immunity & Ageing 2012 9:18

    Content type: Research

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  21. The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV dis...

    Authors: Adam Bunztman, Benjamin G Vincent, Harsha Krovi, Shaun Steele and Jeffrey A Frelinger

    Citation: Immunity & Ageing 2012 9:17

    Content type: Research

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  22. Acute myocardial infarction (AMI) is a multifactorial disease with a complex pathogenesis where lifestyle, individual genetic background and environmental risk factors are involved. Altered inflammatory respon...

    Authors: Manuela Ianni, Sergio Callegari, Antonio Rizzo, Paolo Pastori, Paolo Moruzzi, Domenico Corradi, Elisa Porcellini, Gianluca Campo, Roberto Ferrari, Marco M Ferrario, Stefania Bitonte, Ilaria Carbone and Federico Licastro

    Citation: Immunity & Ageing 2012 9:14

    Content type: Research

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  23. Chlamydia pneumoniae is an obligate intracellular respiratory pathogen for humans. Infection by C. pneumoniae may be linked etiologically to extra-respiratory diseases of aging, especially atherosclerosis. We hav...

    Authors: Taylor Eddens, Sarah Beaudoin, Amanda Steinberger, C Scott Little, Dawn Shell, Benjamin Wizel, Brian Balin and Kerin L Fresa-Dillon

    Citation: Immunity & Ageing 2012 9:11

    Content type: Short report

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  24. The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focus...

    Authors: Carmela R Balistreri, Giuseppina Candore, Giulia Accardi, Manuela Bova, Silvio Buffa, Matteo Bulati, Giusi I Forte, Florinda Listì, Adriana Martorana, Marisa Palmeri, Maria Valeria Pellicanò, Loredana Vaccarino, Letizia Scola, Domenico Lio and Giuseppina Colonna-Romano

    Citation: Immunity & Ageing 2012 9:8

    Content type: Research

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  25. The average life-span of the population of industrialized countries has improved enormously over the last decades. Despite evidence pointing to the role of food intake in modulating life-span, exceptional long...

    Authors: Anna Ferrario, Francesco Villa, Alberto Malovini, Fiorella Araniti and Annibale A Puca

    Citation: Immunity & Ageing 2012 9:7

    Content type: Review

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  26. The extraordinary increase of the elderly in developed countries underscore the importance of studies on ageing and longevity and the need for the prompt spread of knowledge about ageing in order to satisfacto...

    Authors: Calogero Caruso, Giuseppe Passarino, Annibale Puca and Giovanni Scapagnini

    Citation: Immunity & Ageing 2012 9:5

    Content type: Editorial

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  27. World population has experienced continuous growth since 1400 A.D. Current projections show a continued increase - but a steady decline in the population growth rate - with the number expected to reach between...

    Authors: Paolo Mazzola, Saba Radhi, Leonardo Mirandola, Giorgio Annoni, Marjorie Jenkins, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: Immunity & Ageing 2012 9:4

    Content type: Review

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  28. We recently isolated and identified Zizimin2 as a functional factor that is highly expressed in murine splenic germinal center B cells after immunization with T-cell-dependent antigen. Zizimin2 was revealed to...

    Authors: Isamu Sakabe, Azusa Asai, Junko Iijima and Mitsuo Maruyama

    Citation: Immunity & Ageing 2012 9:2

    Content type: Research

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  29. As a chronic antigenic stressor human Cytomegalovirus (CMV) contributes substantially to age-related alterations of the immune system. Even though monocytes have the greatest propensity for CMV-infection and s...

    Authors: Juliane Wolf, Birgit Weinberger and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2012 9:1

    Content type: Short report

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  30. Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the autoimmune destruction of the small intrahepatic bile ducts. The disease has an unpredictable clinical course, but may progre...

    Authors: Daniel S Smyk, Eirini I Rigopoulou, Ana Lleo, Robin D Abeles, Athanasios Mavropoulos, Charalambos Billinis, Pietro Invernizzi and Dimitrios P Bogdanos

    Citation: Immunity & Ageing 2011 8:12

    Content type: Review

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  31. MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any ...

    Authors: Michiyo Ohyashiki, Junko H Ohyashiki, Ayako Hirota, Chiaki Kobayashi and Kazuma Ohyashiki

    Citation: Immunity & Ageing 2011 8:11

    Content type: Short report

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  32. The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory ...

    Authors: Mark Wills, Arne Akbar, Mark Beswick, Jos A Bosch, Calogero Caruso, Giuseppina Colonna-Romano, Ambarish Dutta, Claudio Franceschi, Tamas Fulop, Effrossyni Gkrania-Klotsas, Joerg Goronzy, Stephen J Griffiths, Sian M Henson, Dietmar Herndler-Brandstetter, Ann Hill, Florian Kern…

    Citation: Immunity & Ageing 2011 8:10

    Content type: Commentary

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  33. Old age is associated with increased levels of circulating pro-inflammatory cytokines, a phenomenon termed inflamm-aging. Elevated levels of pro-inflammatory cytokines have been associated with several age-ass...

    Authors: Saara Marttila, Juulia Jylhävä, Carita Eklund, Antti Hervonen, Marja Jylhä and Mikko Hurme

    Citation: Immunity & Ageing 2011 8:9

    Content type: Short report

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  34. Nosocomial infections are extremely common in the elderly and may be related to ageing of the immune system. The Immune Risk Phenotype (IRP), which predicts shorter survival in elderly patients, has not been e...

    Authors: A Plonquet, S Bastuji-Garin, F Tahmasebi, C Brisacier, K Ledudal, JP Farcet and E Paillaud

    Citation: Immunity & Ageing 2011 8:8

    Content type: Research

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  35. Alzheimer's disease is a progressive and neurodegenerative disorder which involves multiple molecular mechanisms. Intense research during the last years has accumulated a large body of data and the search for ...

    Authors: Sergio Davinelli, Mariano Intrieri, Claudio Russo, Alfonso Di Costanzo, Davide Zella, Paolo Bosco and Giovanni Scapagnini

    Citation: Immunity & Ageing 2011 8:7

    Content type: Review

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  36. While influenza vaccination results in protective antibodies against primary infections, clearance of infection is primarily mediated through CD8+ T cells. Studying the CD8+ T cell response to influenza epitopes ...

    Authors: Jessica B Lee, Mathias Oelke, Lakshmi Ramachandra, David H Canaday and Jonathan P Schneck

    Citation: Immunity & Ageing 2011 8:6

    Content type: Research

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  37. With the progressive aging of the human population, there is an inexorable decline in muscle mass, strength and function. Anabolic supplementation with testosterone has been shown to effectively restore muscle...

    Authors: Camellia Banerjee, Jagadish Ulloor, Edgar L Dillon, Qusai Dahodwala, Brittani Franklin, Thomas Storer, Paola Sebastiani, Melinda Sheffield-Moore, Randall J Urban, Shalender Bhasin and Monty Montano

    Citation: Immunity & Ageing 2011 8:5

    Content type: Research

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  38. The increase in life expectancy within the general population has resulted in an increasing number of elderly adults, including patients with Down syndrome (DS), with a current life expectancy of about 50 year...

    Authors: Maria BF Trotta, João B Serro Azul, Mauricio Wajngarten, Simone G Fonseca, Anna C Goldberg and Jorge E Kalil

    Citation: Immunity & Ageing 2011 8:4

    Content type: Research

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  39. Cytomegalovirus (CMV) is a prevalent herpesvirus with links to both stress and aging. This paper describes and validates a minimally invasive method for assessing antibodies against CMV in finger stick whole b...

    Authors: Jennifer B Dowd, Allison E Aiello, Laura Chyu, Yuan-yen Huang and Thomas W McDade

    Citation: Immunity & Ageing 2011 8:3

    Content type: Methodology

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