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  1. Content type: Research

    The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focus...

    Authors: Carmela R Balistreri, Giuseppina Candore, Giulia Accardi, Manuela Bova, Silvio Buffa, Matteo Bulati, Giusi I Forte, Florinda Listì, Adriana Martorana, Marisa Palmeri, Maria Valeria Pellicanò, Loredana Vaccarino, Letizia Scola, Domenico Lio and Giuseppina Colonna-Romano

    Citation: Immunity & Ageing 2012 9:8

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  2. Content type: Review

    World population has experienced continuous growth since 1400 A.D. Current projections show a continued increase - but a steady decline in the population growth rate - with the number expected to reach between...

    Authors: Paolo Mazzola, Saba Radhi, Leonardo Mirandola, Giorgio Annoni, Marjorie Jenkins, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: Immunity & Ageing 2012 9:4

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  3. Content type: Research

    We recently isolated and identified Zizimin2 as a functional factor that is highly expressed in murine splenic germinal center B cells after immunization with T-cell-dependent antigen. Zizimin2 was revealed to...

    Authors: Isamu Sakabe, Azusa Asai, Junko Iijima and Mitsuo Maruyama

    Citation: Immunity & Ageing 2012 9:2

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  4. Content type: Short report

    As a chronic antigenic stressor human Cytomegalovirus (CMV) contributes substantially to age-related alterations of the immune system. Even though monocytes have the greatest propensity for CMV-infection and s...

    Authors: Juliane Wolf, Birgit Weinberger and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2012 9:1

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  5. Content type: Review

    Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the autoimmune destruction of the small intrahepatic bile ducts. The disease has an unpredictable clinical course, but may progre...

    Authors: Daniel S Smyk, Eirini I Rigopoulou, Ana Lleo, Robin D Abeles, Athanasios Mavropoulos, Charalambos Billinis, Pietro Invernizzi and Dimitrios P Bogdanos

    Citation: Immunity & Ageing 2011 8:12

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  6. Content type: Short report

    MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any ...

    Authors: Michiyo Ohyashiki, Junko H Ohyashiki, Ayako Hirota, Chiaki Kobayashi and Kazuma Ohyashiki

    Citation: Immunity & Ageing 2011 8:11

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  7. Content type: Commentary

    The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory ...

    Authors: Mark Wills, Arne Akbar, Mark Beswick, Jos A Bosch, Calogero Caruso, Giuseppina Colonna-Romano, Ambarish Dutta, Claudio Franceschi, Tamas Fulop, Effrossyni Gkrania-Klotsas, Joerg Goronzy, Stephen J Griffiths, Sian M Henson, Dietmar Herndler-Brandstetter, Ann Hill, Florian Kern…

    Citation: Immunity & Ageing 2011 8:10

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  8. Content type: Short report

    Old age is associated with increased levels of circulating pro-inflammatory cytokines, a phenomenon termed inflamm-aging. Elevated levels of pro-inflammatory cytokines have been associated with several age-ass...

    Authors: Saara Marttila, Juulia Jylhävä, Carita Eklund, Antti Hervonen, Marja Jylhä and Mikko Hurme

    Citation: Immunity & Ageing 2011 8:9

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  9. Content type: Research

    Nosocomial infections are extremely common in the elderly and may be related to ageing of the immune system. The Immune Risk Phenotype (IRP), which predicts shorter survival in elderly patients, has not been e...

    Authors: A Plonquet, S Bastuji-Garin, F Tahmasebi, C Brisacier, K Ledudal, JP Farcet and E Paillaud

    Citation: Immunity & Ageing 2011 8:8

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  10. Content type: Review

    Alzheimer's disease is a progressive and neurodegenerative disorder which involves multiple molecular mechanisms. Intense research during the last years has accumulated a large body of data and the search for ...

    Authors: Sergio Davinelli, Mariano Intrieri, Claudio Russo, Alfonso Di Costanzo, Davide Zella, Paolo Bosco and Giovanni Scapagnini

    Citation: Immunity & Ageing 2011 8:7

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  11. Content type: Research

    While influenza vaccination results in protective antibodies against primary infections, clearance of infection is primarily mediated through CD8+ T cells. Studying the CD8+ T cell response to influenza epitopes ...

    Authors: Jessica B Lee, Mathias Oelke, Lakshmi Ramachandra, David H Canaday and Jonathan P Schneck

    Citation: Immunity & Ageing 2011 8:6

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  12. Content type: Research

    With the progressive aging of the human population, there is an inexorable decline in muscle mass, strength and function. Anabolic supplementation with testosterone has been shown to effectively restore muscle...

    Authors: Camellia Banerjee, Jagadish Ulloor, Edgar L Dillon, Qusai Dahodwala, Brittani Franklin, Thomas Storer, Paola Sebastiani, Melinda Sheffield-Moore, Randall J Urban, Shalender Bhasin and Monty Montano

    Citation: Immunity & Ageing 2011 8:5

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  13. Content type: Research

    The increase in life expectancy within the general population has resulted in an increasing number of elderly adults, including patients with Down syndrome (DS), with a current life expectancy of about 50 year...

    Authors: Maria BF Trotta, João B Serro Azul, Mauricio Wajngarten, Simone G Fonseca, Anna C Goldberg and Jorge E Kalil

    Citation: Immunity & Ageing 2011 8:4

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  14. Content type: Methodology

    Cytomegalovirus (CMV) is a prevalent herpesvirus with links to both stress and aging. This paper describes and validates a minimally invasive method for assessing antibodies against CMV in finger stick whole b...

    Authors: Jennifer B Dowd, Allison E Aiello, Laura Chyu, Yuan-yen Huang and Thomas W McDade

    Citation: Immunity & Ageing 2011 8:3

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  15. Content type: Research

    The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched he...

    Authors: Nicolle HR Litjens, Elly A de Wit and Michiel GH Betjes

    Citation: Immunity & Ageing 2011 8:2

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  16. Content type: Research

    Immunosenescence is the age-related decline and dysfunction of protective immunity leading to a marked increase in the risk of infections, autoimmune disease, and cancer. The majority of studies have focused o...

    Authors: Keely G McDonald, Matthew R Leach, Conway Huang, Caihong Wang and Rodney D Newberry

    Citation: Immunity & Ageing 2011 8:1

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  17. Content type: Proceedings

    Alzheimer’s disease (AD) is one of the most frequent cause of neurodegenerative disorder in the elderly. Inflammation has been implicated in brain degenerative processes and peripheral markers of brain AD rela...

    Authors: Manuela Ianni, Marcella Manerba, Giuseppina Di Stefano, Elisa Porcellini, Martina Chiappelli, Ilaria Carbone and Federico Licastro

    Citation: Immunity & Ageing 2010 7(Suppl 1):S6

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    This article is part of a Supplement: Volume 7 Supplement 1

  18. Content type: Proceedings

    The population longitudinal study named “The Conselice Study” has been the focus of the present investigation. 65 years old or older participants of this population study on brain aging were followed up for 5 ...

    Authors: Federico Licastro, Elisa Porcellini, Paola Forti, Massimo Buscema, Ilaria Carbone, Giovanni Ravaglia and Enzo Grossi

    Citation: Immunity & Ageing 2010 7(Suppl 1):S4

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    This article is part of a Supplement: Volume 7 Supplement 1

  19. Content type: Proceedings

    Among the age-related diseases, the development of cognitive impairments, in particular dementia, is the most devastating for the individual and has great social and healthcare costs. Accurate information is n...

    Authors: Giovanni Ravaglia and Paola Forti

    Citation: Immunity & Ageing 2010 7(Suppl 1):S2

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    This article is part of a Supplement: Volume 7 Supplement 1

  20. Content type: Proceedings

    It has been reported that cellular prion protein (PrPc) co-localizes with caveolin-1 and participates to signal transduction events by recruiting Fyn kinase. As PrPc is a secreted protein anchored to the outer su...

    Authors: Vittorio Tomasi

    Citation: Immunity & Ageing 2010 7(Suppl 1):S5

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    This article is part of a Supplement: Volume 7 Supplement 1

  21. Content type: Proceedings

    An individual patient is not the average representative of the population. Rather he or she is a person with unique characteristics. An intervention may be effective for a population but not necessarily for th...

    Authors: Enzo Grossi

    Citation: Immunity & Ageing 2010 7(Suppl 1):S3

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    This article is part of a Supplement: Volume 7 Supplement 1

  22. Content type: Proceedings

    Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or ne...

    Authors: Federico Licastro and Calogero Caruso

    Citation: Immunity & Ageing 2010 7(Suppl 1):S1

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    This article is part of a Supplement: Volume 7 Supplement 1

  23. Content type: Short report

    Periodontal disease is a chronic inflammatory gum disease that in severe cases leads to tooth loss. Porphyromonas gingivalis (Pg) is a bacterium closely associated with generalized forms of periodontal disease. C...

    Authors: Yazdani B Shaik-Dasthagirisaheb, Alpdogan Kantarci and Frank C Gibson III

    Citation: Immunity & Ageing 2010 7:15

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  24. Content type: Research

    Respiratory syncytial virus (RSV) is the major pathogen causing respiratory disease in young infants and it is an important cause of serious illness in the elderly since the infection provides limited immune p...

    Authors: Maria Grazia Cusi, Barbara Martorelli, Giuseppa Di Genova, Chiara Terrosi, Giuseppe Campoccia and Pierpaolo Correale

    Citation: Immunity & Ageing 2010 7:14

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  25. Content type: Short report

    The tuberculosis (TB) still increases in the number of new cases, which is estimated to approach 10 million in 2010. The number of aged people has been growing all over the world. Ageing is one of risk factors...

    Authors: Tsukasa Ito, Takemasa Takii, Mitsuo Maruyama, Daisuke Hayashi, Takeshi Wako, Azusa Asai, Yasuhiro Horita, Keiichi Taniguchi, Ikuya Yano, Saburo Yamamoto and Kikuo Onozaki

    Citation: Immunity & Ageing 2010 7:12

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  26. Content type: Research

    Immunoglobulin A (IgA) secretion in saliva decreases with age and may be the cause of increased vulnerability of the elderly to respiratory infections. The effect of oral intake of lactic acid bacteria on sali...

    Authors: Yoshifumi Kotani, Shoji Shinkai, Hiroshi Okamatsu, Masamichi Toba, Kishiko Ogawa, Hiroto Yoshida, Taro Fukaya, Yoshinori Fujiwara, Paulo HM Chaves, Keiji Kakumoto and Noriyuki Kohda

    Citation: Immunity & Ageing 2010 7:11

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  27. Content type: Research

    The immune system gradually deteriorates with age and nutritional status is a major factor in immunosenescence. Of the many nutritional factors implicated in age-related immune dysfunction, vitamin A may be a ...

    Authors: Régine Minet-Quinard, M Chantal Farges, Emilie Thivat, Cécile Deleine, Gilles Mayot, Julius Brtko, Josep Ribalta, Brigitte Winklhofer-Roob, Edmond Rock and M Paule Vasson

    Citation: Immunity & Ageing 2010 7:10

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  28. Content type: Research

    Infectious diseases are significant causes of morbidity and mortality among elderly populations. However, the relationship between oxidative stress, immune function and inflammatory response in acute phase of ...

    Authors: Thi Kim Duy Vo, Patrice Godard, Marie de Saint-Hubert, Gabriel Morrhaye, Christian Swine, Vincent Geenen, Henri J Martens, Florence Debacq-Chainiaux and Olivier Toussaint

    Citation: Immunity & Ageing 2010 7:9

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  29. Content type: Review

    The increasing ratio of ageing population poses new challenges to healthcare systems. The elderly frequently suffer from severe infections. Vaccination could protect them against several infectious diseases, b...

    Authors: Joseph Ongrádi and Valéria Kövesdi

    Citation: Immunity & Ageing 2010 7:7

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  30. Content type: Research

    There is reported to be a decline in immune function and an alteration in the frequency of circulating lymphocytes with advancing age. There are also differences in ageing and lifespan between males and female...

    Authors: Jun Yan, Judith M Greer, Renee Hull, John D O'Sullivan, Robert D Henderson, Stephen J Read and Pamela A McCombe

    Citation: Immunity & Ageing 2010 7:4

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  31. Content type: Research

    Oncogenic γ-herpesviruses establish life-long infections in their hosts and control of these latent infections is dependent on continual immune surveillance. Immune function declines with age, raising the poss...

    Authors: Eric J Yager, In-Jeong Kim, Michael L Freeman, Kathleen G Lanzer, Claire E Burkum, Tres Cookenham, David L Woodland and Marcia A Blackman

    Citation: Immunity & Ageing 2010 7:3

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  32. Content type: Short report

    The prevalence of coronary artery diseases is low among Down Syndrome (DS) patients and they rarely die of atherosclerotic complications. Histopathological investigations showed no increase in atherosclerosis,...

    Authors: Giada Dogliotti, Emanuela Galliera, Federico Licastro and Massimiliano M Corsi

    Citation: Immunity & Ageing 2010 7:2

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  33. Content type: Review

    A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy between April 7 and 8th 2009. Here the lecture by Sikora with some input from the chairpersons Scapagnini...

    Authors: E Sikora, Giovanni Scapagnini and Mario Barbagallo

    Citation: Immunity & Ageing 2010 7:1

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  34. Content type: Review

    The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear.

    Authors: Francesco Iemolo, Giovanni Duro, Claudia Rizzo, Laura Castiglia, Vladimir Hachinski and Calogero Caruso

    Citation: Immunity & Ageing 2009 6:13

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  35. Content type: Review

    A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi, L. Ginaldi and F. Licastro are here ...

    Authors: Giuseppina Campisi, Martina Chiappelli, Massimo De Martinis, Vito Franco, Lia Ginaldi, Rosario Guiglia, Federico Licastro and Domenico Lio

    Citation: Immunity & Ageing 2009 6:12

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  36. Content type: Research

    Ageing is associated with changes in the immune system with substantial alterations in T-lymphocyte subsets. Cytomegalovirus (CMV) is one of the factors that affect functionality of T cells and the differentia...

    Authors: María Luisa Pita-Lopez, Inmaculada Gayoso, Olga DelaRosa, Javier G Casado, Corona Alonso, Elisa Muñoz-Gomariz, Raquel Tarazona and Rafael Solana

    Citation: Immunity & Ageing 2009 6:11

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  37. Content type: Short report

    On April 7,8, 2009 a Symposium entitled "Pathophysiology of Successful and Unsuccessful Ageing" took place in Palermo, Italy. Here, the lectures of G. Pawelec, D. Dunn-Walters and. G. Colonna-Romano on T and B...

    Authors: Calogero Caruso, Silvio Buffa, Giuseppina Candore, Giuseppina Colonna-Romano, Deborah Dunn-Walters, David Kipling and Graham Pawelec

    Citation: Immunity & Ageing 2009 6:10

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  38. Content type: Review

    The trace element zinc is essential for the immune system, and zinc deficiency affects multiple aspects of innate and adaptive immunity. There are remarkable parallels in the immunological changes during aging...

    Authors: Hajo Haase and Lothar Rink

    Citation: Immunity & Ageing 2009 6:9

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  39. Content type: Research

    Rheumatoid arthritis (RA) most often begins in females in the fourth-fifth decade of their life, suggesting that the aging of the immune system (immunosenescence) has a major role in this disease. Therefore, i...

    Authors: Oktavia Tarjanyi, Ferenc Boldizsar, Peter Nemeth, Katalin Mikecz and Tibor T Glant

    Citation: Immunity & Ageing 2009 6:8

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  40. Content type: Research

    The innate immune system plays an important role in the recognition and induction of protective responses against infectious pathogens, whilst there is increasing evidence for a role in mediating chronic infla...

    Authors: Linda May, Anita HJ van den Biggelaar, David van Bodegom, Hans J Meij, Anton JM de Craen, Joseph Amankwa, Marijke Frölich, Maris Kuningas and Rudi GJ Westendorp

    Citation: Immunity & Ageing 2009 6:7

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