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  1. Content type: Research

    The research literature has documented age-related increases in genetic damage, including oxidative DNA damage, in human T lymphocytes, in vitro and ex vivo. Such damage has the potential to interfere with the ab...

    Authors: Shiva Marthandan, Paul Hyland, Graham Pawelec and Yvonne Barnett

    Citation: Immunity & Ageing 2013 10:7

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  2. Content type: Research

    Neurodegenerative disorders such Alzheimer's disease (AD) are often characterized by senile plaques and neurofibrillary tangle. In addition, reactive astrogliosis, microglia activation and a chronic inflammati...

    Authors: Elisa Porcellini, Manuela Ianni, Ilaria Carbone, Massimo Franceschi and Federico Licastro

    Citation: Immunity & Ageing 2013 10:6

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  3. Content type: Research

    Advanced age results in crucial alterations of the innate and adaptive immune system leading to functional defects resulting in infection and chronic diseases. Toll-like receptors (TLR) recognize pathogenic st...

    Authors: Peter Uciechowski, Eva Maria Oellig, Erminia Mariani, Marco Malavolta, Eugenio Mocchegiani and Lothar Rink

    Citation: Immunity & Ageing 2013 10:4

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  4. Content type: Short report

    Aging is considered an important independent risk factor for atherosclerosis. Down syndrome people (DS) display an accelerated aging process compared to healthy subjects, anyway they are relatively resistant t...

    Authors: Elena Vianello, Giada Dogliotti, Elena Dozio and Massimiliano Marco Corsi Romanelli

    Citation: Immunity & Ageing 2013 10:2

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  5. Content type: Research

    Multiple Sclerosis (MS) is a multi-factorial disease, where a single biomarker unlikely can provide comprehensive information. Moreover, due to the non-linearity of biomarkers, traditional statistic is both un...

    Authors: Maira Gironi, Marina Saresella, Marco Rovaris, Matilde Vaghi, Raffaello Nemni, Mario Clerici and Enzo Grossi

    Citation: Immunity & Ageing 2013 10:1

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  6. Content type: Research

    Virus-specific memory CD8+ T cells persist long after infection is resolved and are important for mediating recall responses to secondary infection. Although the number of memory T cells remains relatively consta...

    Authors: Lisa M Connor, Jacob E Kohlmeier, Lynn Ryan, Alan D Roberts, Tres Cookenham, Marcia A Blackman and David L Woodland

    Citation: Immunity & Ageing 2012 9:28

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    The Erratum to this article has been published in Immunity & Ageing 2013 10:40

  7. Content type: Short report

    Cytokines regulated by the inflammasome pathway have been extensively implicated in various age-related immune pathologies. We set out to elucidate the contribution of the nod-like receptor protein 3 (NLRP3) i...

    Authors: Alejandro Ramirez, Vijay Rathinam, Katherine A Fitzgerald, Douglas T Golenbock and Anuja Mathew

    Citation: Immunity & Ageing 2012 9:27

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  8. Content type: Review

    Aging is the sum of the deleterious changes that occur as time goes by. It is the main risk factor for the development of cardiovascular disease, and aging of the vasculature is the event that most often impac...

    Authors: Annibale Alessandro Puca, Albino Carrizzo, Anna Ferrario, Francesco Villa and Carmine Vecchione

    Citation: Immunity & Ageing 2012 9:26

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  9. Content type: Research

    Questions remain about whether inflammation is a cause, consequence, or coincidence of aging. The purpose of this study was to define baseline immunological characteristics from blood to develop a model in rhe...

    Authors: Elizabeth S Didier, Chie Sugimoto, Lisa C Bowers, Imtiaz A Khan and Marcelo J Kuroda

    Citation: Immunity & Ageing 2012 9:25

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  10. Content type: Hypothesis

    The control of human health and diseases in the elderly population is becoming a challenge, since mean age and life expectation are progressively increasing as well as chronic degenerative diseases. These diso...

    Authors: Anna Maria Berghella, Ida Contasta, Tiziana Del Beato and Patrizia Pellegrini

    Citation: Immunity & Ageing 2012 9:24

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  11. Content type: Review

    Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases ...

    Authors: Rafael Solana, Raquel Tarazona, Allison E Aiello, Arne N Akbar, Victor Appay, Mark Beswick, Jos A Bosch, Carmen Campos, Sara Cantisán, Luka Cicin-Sain, Evelyna Derhovanessian, Sara Ferrando-Martínez, Daniela Frasca, Tamas Fulöp, Sheila Govind, Beatrix Grubeck-Loebenstein…

    Citation: Immunity & Ageing 2012 9:23

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  12. Content type: Research

    Thrombolytic therapy (TT) for acute ischemic stroke (AIS) can provoke bleeding’s complication depending on the ischemic lesion (IL) dimension. Inflammation involved in the setting of acute ischaemic stroke, is...

    Authors: Aliaksei Kisialiou, Giordana Pelone, Albino Carrizzo, Giovanni Grillea, Valentina Trimarco, Marina Marino, Michelangelo Bartolo, Alessandro Marco De Nunzio, Rodolfo Grella, Alessandro Landolfi, Annibale Puca, Claudio Colonnese and Carmine Vecchione

    Citation: Immunity & Ageing 2012 9:22

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  13. Content type: Research

    Respiratory Syncytial Virus (RSV) causes significant disease in the elderly, in part, because immunosenescence impairs protective immune responses to infection in this population. Despite previous and current ...

    Authors: Anu Cherukuri, Kate L Stokes, Kathryn Patton, Howard Kuo, Kaori Sakamoto, Stacie Lambert, Elizabeth Stillman, Martin L Moore and Sujin Lee

    Citation: Immunity & Ageing 2012 9:21

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  14. Content type: Review

    Alzheimer Disease (AD) is the most common neurodegenerative disorder worldwide, and account for 60% to 70% of all cases of progressive cognitive impairment in elderly patients. At the microscopic level distinc...

    Authors: Silvia Catricala, Mauro Torti and Giovanni Ricevuti

    Citation: Immunity & Ageing 2012 9:20

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  15. Content type: Research

    End-stage renal disease (ESRD) patients treated with renal replacement therapy (RRT) have premature immunologically aged T cells which may underlie uremia-associated immune dysfunction. The aim of this study w...

    Authors: Ruud WJ Meijers, Nicolle HR Litjens, Elly A de Wit, Anton W Langerak, Ashley van der Spek, Carla C Baan, Willem Weimar and Michiel GH Betjes

    Citation: Immunity & Ageing 2012 9:19

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  16. Content type: Research

    Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor...

    Authors: Sijia Chen, Anton JM de Craen, Yotam Raz, Evelyna Derhovanessian, Ann Vossen CTM, Rudi Westendorp GJ, Graham Pawelec and Andrea B Maier

    Citation: Immunity & Ageing 2012 9:18

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  17. Content type: Research

    The memory response to LCMV in mice persists for months to years with only a small decrease in the number of epitope specific CD8 T cells. This long persistence is associated with resistance to lethal LCMV dis...

    Authors: Adam Bunztman, Benjamin G Vincent, Harsha Krovi, Shaun Steele and Jeffrey A Frelinger

    Citation: Immunity & Ageing 2012 9:17

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  18. Content type: Research

    Acute myocardial infarction (AMI) is a multifactorial disease with a complex pathogenesis where lifestyle, individual genetic background and environmental risk factors are involved. Altered inflammatory respon...

    Authors: Manuela Ianni, Sergio Callegari, Antonio Rizzo, Paolo Pastori, Paolo Moruzzi, Domenico Corradi, Elisa Porcellini, Gianluca Campo, Roberto Ferrari, Marco M Ferrario, Stefania Bitonte, Ilaria Carbone and Federico Licastro

    Citation: Immunity & Ageing 2012 9:14

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  19. Content type: Short report

    Chlamydia pneumoniae is an obligate intracellular respiratory pathogen for humans. Infection by C. pneumoniae may be linked etiologically to extra-respiratory diseases of aging, especially atherosclerosis. We hav...

    Authors: Taylor Eddens, Sarah Beaudoin, Amanda Steinberger, C Scott Little, Dawn Shell, Benjamin Wizel, Brian Balin and Kerin L Fresa-Dillon

    Citation: Immunity & Ageing 2012 9:11

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  20. Content type: Research

    The demographic and social changes of the past decades have determined improvements in public health and longevity. So, the number of centenarians is increasing as a worldwide phenomenon. Scientists have focus...

    Authors: Carmela R Balistreri, Giuseppina Candore, Giulia Accardi, Manuela Bova, Silvio Buffa, Matteo Bulati, Giusi I Forte, Florinda Listì, Adriana Martorana, Marisa Palmeri, Maria Valeria Pellicanò, Loredana Vaccarino, Letizia Scola, Domenico Lio and Giuseppina Colonna-Romano

    Citation: Immunity & Ageing 2012 9:8

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  21. Content type: Review

    The average life-span of the population of industrialized countries has improved enormously over the last decades. Despite evidence pointing to the role of food intake in modulating life-span, exceptional long...

    Authors: Anna Ferrario, Francesco Villa, Alberto Malovini, Fiorella Araniti and Annibale A Puca

    Citation: Immunity & Ageing 2012 9:7

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  22. Content type: Editorial

    The extraordinary increase of the elderly in developed countries underscore the importance of studies on ageing and longevity and the need for the prompt spread of knowledge about ageing in order to satisfacto...

    Authors: Calogero Caruso, Giuseppe Passarino, Annibale Puca and Giovanni Scapagnini

    Citation: Immunity & Ageing 2012 9:5

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  23. Content type: Review

    World population has experienced continuous growth since 1400 A.D. Current projections show a continued increase - but a steady decline in the population growth rate - with the number expected to reach between...

    Authors: Paolo Mazzola, Saba Radhi, Leonardo Mirandola, Giorgio Annoni, Marjorie Jenkins, Everardo Cobos and Maurizio Chiriva-Internati

    Citation: Immunity & Ageing 2012 9:4

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  24. Content type: Research

    We recently isolated and identified Zizimin2 as a functional factor that is highly expressed in murine splenic germinal center B cells after immunization with T-cell-dependent antigen. Zizimin2 was revealed to...

    Authors: Isamu Sakabe, Azusa Asai, Junko Iijima and Mitsuo Maruyama

    Citation: Immunity & Ageing 2012 9:2

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  25. Content type: Short report

    As a chronic antigenic stressor human Cytomegalovirus (CMV) contributes substantially to age-related alterations of the immune system. Even though monocytes have the greatest propensity for CMV-infection and s...

    Authors: Juliane Wolf, Birgit Weinberger and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2012 9:1

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  26. Content type: Review

    Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the autoimmune destruction of the small intrahepatic bile ducts. The disease has an unpredictable clinical course, but may progre...

    Authors: Daniel S Smyk, Eirini I Rigopoulou, Ana Lleo, Robin D Abeles, Athanasios Mavropoulos, Charalambos Billinis, Pietro Invernizzi and Dimitrios P Bogdanos

    Citation: Immunity & Ageing 2011 8:12

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  27. Content type: Short report

    MicroRNA (miR)-17-92a expression plays a crucial role in lymphocyte ontogeny. We therefore set out to determine miR-92a expression levels in peripheral blood lymphocytes from healthy subjects to ascertain any ...

    Authors: Michiyo Ohyashiki, Junko H Ohyashiki, Ayako Hirota, Chiaki Kobayashi and Kazuma Ohyashiki

    Citation: Immunity & Ageing 2011 8:11

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  28. Content type: Commentary

    The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory ...

    Authors: Mark Wills, Arne Akbar, Mark Beswick, Jos A Bosch, Calogero Caruso, Giuseppina Colonna-Romano, Ambarish Dutta, Claudio Franceschi, Tamas Fulop, Effrossyni Gkrania-Klotsas, Joerg Goronzy, Stephen J Griffiths, Sian M Henson, Dietmar Herndler-Brandstetter, Ann Hill, Florian Kern…

    Citation: Immunity & Ageing 2011 8:10

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  29. Content type: Short report

    Old age is associated with increased levels of circulating pro-inflammatory cytokines, a phenomenon termed inflamm-aging. Elevated levels of pro-inflammatory cytokines have been associated with several age-ass...

    Authors: Saara Marttila, Juulia Jylhävä, Carita Eklund, Antti Hervonen, Marja Jylhä and Mikko Hurme

    Citation: Immunity & Ageing 2011 8:9

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  30. Content type: Research

    Nosocomial infections are extremely common in the elderly and may be related to ageing of the immune system. The Immune Risk Phenotype (IRP), which predicts shorter survival in elderly patients, has not been e...

    Authors: A Plonquet, S Bastuji-Garin, F Tahmasebi, C Brisacier, K Ledudal, JP Farcet and E Paillaud

    Citation: Immunity & Ageing 2011 8:8

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  31. Content type: Review

    Alzheimer's disease is a progressive and neurodegenerative disorder which involves multiple molecular mechanisms. Intense research during the last years has accumulated a large body of data and the search for ...

    Authors: Sergio Davinelli, Mariano Intrieri, Claudio Russo, Alfonso Di Costanzo, Davide Zella, Paolo Bosco and Giovanni Scapagnini

    Citation: Immunity & Ageing 2011 8:7

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  32. Content type: Research

    While influenza vaccination results in protective antibodies against primary infections, clearance of infection is primarily mediated through CD8+ T cells. Studying the CD8+ T cell response to influenza epitopes ...

    Authors: Jessica B Lee, Mathias Oelke, Lakshmi Ramachandra, David H Canaday and Jonathan P Schneck

    Citation: Immunity & Ageing 2011 8:6

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  33. Content type: Research

    With the progressive aging of the human population, there is an inexorable decline in muscle mass, strength and function. Anabolic supplementation with testosterone has been shown to effectively restore muscle...

    Authors: Camellia Banerjee, Jagadish Ulloor, Edgar L Dillon, Qusai Dahodwala, Brittani Franklin, Thomas Storer, Paola Sebastiani, Melinda Sheffield-Moore, Randall J Urban, Shalender Bhasin and Monty Montano

    Citation: Immunity & Ageing 2011 8:5

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  34. Content type: Research

    The increase in life expectancy within the general population has resulted in an increasing number of elderly adults, including patients with Down syndrome (DS), with a current life expectancy of about 50 year...

    Authors: Maria BF Trotta, João B Serro Azul, Mauricio Wajngarten, Simone G Fonseca, Anna C Goldberg and Jorge E Kalil

    Citation: Immunity & Ageing 2011 8:4

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  35. Content type: Methodology

    Cytomegalovirus (CMV) is a prevalent herpesvirus with links to both stress and aging. This paper describes and validates a minimally invasive method for assessing antibodies against CMV in finger stick whole b...

    Authors: Jennifer B Dowd, Allison E Aiello, Laura Chyu, Yuan-yen Huang and Thomas W McDade

    Citation: Immunity & Ageing 2011 8:3

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  36. Content type: Research

    The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched he...

    Authors: Nicolle HR Litjens, Elly A de Wit and Michiel GH Betjes

    Citation: Immunity & Ageing 2011 8:2

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  37. Content type: Research

    Immunosenescence is the age-related decline and dysfunction of protective immunity leading to a marked increase in the risk of infections, autoimmune disease, and cancer. The majority of studies have focused o...

    Authors: Keely G McDonald, Matthew R Leach, Conway Huang, Caihong Wang and Rodney D Newberry

    Citation: Immunity & Ageing 2011 8:1

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  38. Content type: Proceedings

    An individual patient is not the average representative of the population. Rather he or she is a person with unique characteristics. An intervention may be effective for a population but not necessarily for th...

    Authors: Enzo Grossi

    Citation: Immunity & Ageing 2010 7(Suppl 1):S3

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    This article is part of a Supplement: Volume 7 Supplement 1

  39. Content type: Proceedings

    Progressive increase of mean age and life expectancy in both industrialized and emerging societies parallels an increment of chronic degenerative diseases (CDD) such as cancer, cardiovascular, autoimmune or ne...

    Authors: Federico Licastro and Calogero Caruso

    Citation: Immunity & Ageing 2010 7(Suppl 1):S1

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    This article is part of a Supplement: Volume 7 Supplement 1

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