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  1. This study investigates the presence of antinuclear antibodies (ANA) in three primary synucleinopathies – Parkinson’s disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), compared ...

    Authors: Jonas Folke, Marie Skougaard, Trine-Line Korsholm, Anne-Line Strange Laursen, Lisette Salvesen, Anne-Mette Hejl, Sara Bech, Annemette Løkkegaard, Tomasz Brudek, Sisse Bolm Ditlev and Susana Aznar
    Citation: Immunity & Ageing 2024 21:49
  2. Aging is associated with significant structural and functional changes in the spleen, leading to immunosenescence, yet the detailed effects on splenic vascular endothelial cells (ECs) and their immunomodulator...

    Authors: Yanjing Huang, Zhong Liu, Mengke Li, Dongliang Wang, Jinguo Ye, Qiuling Hu, Qikai Zhang, Yuheng Lin, Rongxin Chen, Xuanwei Liang, Xingyi Li and Xianchai Lin
    Citation: Immunity & Ageing 2024 21:48
  3. The function of polymorphonuclear neutrophils (PMNs) decreases with age, which results in infectious and inflammatory complications in older individuals. The underlying causes are not fully understood. ATP rel...

    Authors: Carola Ledderose, Eleftheria-Angeliki Valsami, Mark Elevado, Qing Liu, Brennan Giva, Julian Curatolo, Joshua Delfin, Reem Abutabikh and Wolfgang G. Junger
    Citation: Immunity & Ageing 2024 21:45
  4. Although it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the susceptibility of centenarians. Two epidemiological study have shown that older cen...

    Authors: Claudia Maria Trombetta, Giulia Accardi, Anna Aiello, Anna Calabrò, Calogero Caruso, Mattia Emanuela Ligotti, Serena Marchi, Emanuele Montomoli, Martin Mayora Neto, Nigel Temperton and Giuseppina Candore
    Citation: Immunity & Ageing 2024 21:44
  5. Neutrophils play an essential role in Alzheimer’s disease (AD) pathology. However, the extent of their heterogeneity remains poorly explored, particularly in the context of developing novel therapies targeting...

    Authors: Xiaolin Zhang, Guiqin He, Yixuan Hu, Boren Liu, Yuliang Xu, Xia Li, Xinyou Lv and Jin Li
    Citation: Immunity & Ageing 2024 21:42
  6. The magnitude and durability of cell-mediated immunity in older and severely frail individuals following coronavirus disease 2019 (COVID-19) vaccination remain unclear. A controlled immune response could be th...

    Authors: Tomoyuki Kakugawa, Yusuke Mimura, Yuka Mimura-Kimura, Keiko Doi, Yuichi Ohteru, Hiroyuki Kakugawa, Keiji Oishi, Masahiro Kakugawa, Tsunahiko Hirano and Kazuto Matsunaga
    Citation: Immunity & Ageing 2024 21:41
  7. Age > 65 years is a key risk factor for poor outcomes after human influenza infection. Specifically, in addition to respiratory disease, non-neurotropic influenza A virus (IAV) causes neuro-cognitive complicat...

    Authors: Wenxin Wu, Jeremy S. Alexander, J. Leland Booth, Craig A. Miller, Jordan P. Metcalf and Douglas A. Drevets
    Citation: Immunity & Ageing 2024 21:39
  8. Global life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable marker of immune system aging is the presence of Aging-Related Immune Ce...

    Authors: Ahmed A. Y. Ragab, Margaret F. Doyle, Jiachen Chen, Yuan Fang, Kathryn L. Lunetta and Joanne M. Murabito
    Citation: Immunity & Ageing 2024 21:37
  9. The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called TEMRA) are important during aging an...

    Authors: Edric Winford, Jenny Lutshumba, Barbara J. Martin, Donna M. Wilcock, Gregory A. Jicha, Barbara S. Nikolajczyk, Ann M. Stowe and Adam D. Bachstetter
    Citation: Immunity & Ageing 2024 21:36
  10. Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci requires robust pulmonary neutrophil influx early in infection. However, aging is associa...

    Authors: Shaunna R. Simmons, Sydney E. Herring, Essi Y.I Tchalla, Alexsandra P. Lenhard, Manmeet Bhalla and Elsa N. Bou Ghanem
    Citation: Immunity & Ageing 2024 21:34
  11. Research has suggested significant correlations among ageing, immune microenvironment, inflammation and tumours. However, the relationships among ageing, immune microenvironment, cystitis and bladder urothelia...

    Authors: Jiang Zhao, Xing Luo, Chengfei Yang, Xiao Yang, Min Deng, Bishao Sun, Jingzhen Zhu, Zongming Dong, Yangcai Wang, Jia Li, Xingliang Yang, Benyi Li, Xiangwei Wang and Ji Zheng
    Citation: Immunity & Ageing 2024 21:33
  12. An elevated neutrophil–lymphocyte ratio (NLR) in blood has been associated with Alzheimer’s disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD...

    Authors: Tovia Jacobs, Sean R. Jacobson, Juan Fortea, Jeffrey S. Berger, Alok Vedvyas, Karyn Marsh, Tianshe He, Eugenio Gutierrez-Jimenez, Nathanael R. Fillmore, Moses Gonzalez, Luisa Figueredo, Naomi L. Gaggi, Chelsea Reichert Plaska, Nunzio Pomara, Esther Blessing, Rebecca Betensky…
    Citation: Immunity & Ageing 2024 21:32
  13. The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. Irisin, a muscle-derived hormone produced by the proteolytic cleavage of Fibronectin-do...

    Authors: Cailin Wang, Xiufeng Wang, Shangqi Sun, Yanmin Chang, Piaopiao Lian, Hongxiu Guo, Siyi Zheng, Rong Ma and Gang Li
    Citation: Immunity & Ageing 2024 21:30
  14. Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative, anti-inflammatory, anticancer, neuroprotective and senescent cell-clearing a...

    Authors: Tingting Su, Haitao Shen, Mengyuan He, Shanshan Yang, Xue Gong, Ce Huang, Liuling Guo, Hao Wang, Shengyu Feng, Taotao Mi, Meili Zhao, Qing Liu, Fengjiao Huo, Jian-Kang Zhu, Jianbo Zhu, Hongbin Li…
    Citation: Immunity & Ageing 2024 21:29
  15. Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chroni...

    Authors: Johanne Poisson, Carine El-Sissy, Arnaud Serret-Larmande, Nikaïa Smith, Morgane Lebraud, Jean-Loup Augy, Catherine Conti, Cécile Gonnin, Benjamin Planquette, Jean-Benoît Arlet, Bertrand Hermann, Bruno Charbit, Jean Pastre, Floriane Devaux, Cyrielle Ladavière, Lydie Lim…
    Citation: Immunity & Ageing 2024 21:28
  16. Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized by lipid accumulation and immune cell responses in the vascular wall, resulting in plaq...

    Authors: Virginia Smit, Jill de Mol, Mireia N. A. Bernabé Kleijn, Marie A. C. Depuydt, Menno P. J. de Winther, Ilze Bot, Johan Kuiper and Amanda C. Foks
    Citation: Immunity & Ageing 2024 21:27
  17. Authors: Qinqin Pan, Xiao Ma, Yajie You, Yuejiao Yu, Su Fan, Xiaoyan Wang, Mengyuan Wang, Ming Gao, Guangming Gong, Kourong Miao, Jie Shen and Xiaoyu Zhou
    Citation: Immunity & Ageing 2024 21:25

    The original article was published in Immunity & Ageing 2024 21:15

  18. The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities with lymph nodes and participate as inductive organs of systemic and mucosal immunity. ...

    Authors: Rocío Pastor, Juliana Puyssegur, M. Paula de la Guardia, Lindybeth Sarmiento Varón, Gladys Beccaglia, Nicolás Spada, Andrea Paes de Lima, M. Soledad Collado, Andrés Blanco, Isabel Aspe Scetti, M. Elena Arabolaza, Bibiana Paoli, Fernando Chirdo and Eloísa Arana
    Citation: Immunity & Ageing 2024 21:24
  19. It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk Factors, Aging and Dementia (CAIDE) model.

    Authors: Kira Trares, Manuel Wiesenfarth, Hannah Stocker, Laura Perna, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner and Ben Schöttker
    Citation: Immunity & Ageing 2024 21:23
  20. Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ZAP70+CD5+ B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1+ alone. In mice, TCL1 (TCL1A) is th...

    Authors: Kyoko Hayakawa, Yan Zhou and Susan A. Shinton
    Citation: Immunity & Ageing 2024 21:22
  21. Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations and mortality. The recent COVID-19 pandemic has hig...

    Authors: Sudhanshu Agrawal, Michelle Thu Tran, Tara Sinta Kartika Jennings, Marlaine Maged Hosny Soliman, Sally Heo, Bobby Sasson, Farah Rahmatpanah and Anshu Agrawal
    Citation: Immunity & Ageing 2024 21:21
  22. People living with HIV (PLWH) are at risk of frailty, which is predictive for death. As an overactivity of the immune system is thought to fuel frailty, we characterized the immune activation profiles linked t...

    Authors: Lucy Kundura, Renaud Cezar, Sandrine Gimenez, Manuela Pastore, Christelle Reynes, Albert Sotto, Jacques Reynes, Clotilde Allavena, Laurence Meyer, Alain Makinson and Pierre Corbeau
    Citation: Immunity & Ageing 2024 21:20
  23. Increased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so called chronic low-grade inflammation, which contributes to a faster progression of aged-r...

    Authors: Monica Cattaneo, Andrea Baragetti, Alberto Malovini, Elena Ciaglia, Valentina Lopardo, Elena Olmastroni, Manuela Casula, Carolina Ciacci, Alberico L. Catapano and Annibale A. Puca
    Citation: Immunity & Ageing 2024 21:19
  24. Turquoise killifish (Nothobranchius furzeri) evolved a naturally short lifespan of about six months and exhibit aging hallmarks that affect multiple organs. These hallmarks include protein aggregation, telomere s...

    Authors: Gabriele Morabito, Alina Ryabova and Dario Riccardo Valenzano
    Citation: Immunity & Ageing 2024 21:18
  25. Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and par...

    Authors: Mailton Prestes Madruga, Lucas Kich Grun, Letícya Simone Melo Dos Santos, Frederico Orlando Friedrich, Douglas Bitencourt Antunes, Marcella Elesbão Fogaça Rocha, Pedro Luis Silva, Gilson P. Dorneles, Paula Coelho Teixeira, Tiago Franco Oliveira, Pedro R.T. Romão, Lucas Santos, José Claudio Fonseca Moreira, Vinicius Schenk Michaelsen, Marcelo Cypel, Marcos Otávio Brum Antunes…
    Citation: Immunity & Ageing 2024 21:17
  26. With the development of Hematopoietic Stem Cell Transplantation (HSCT) technology, increasing numbers of elderly patients were undergoing allogeneic HSCT and elderly patients with hematologic malignancies coul...

    Authors: Qinqin Pan, Xiao Ma, Yajie You, Yuejiao Yu, Su Fan, Xiaoyan Wang, Mengyuan Wang, Ming Gao, Guangming Gong, Kourong Miao, Jie Shen and Xiaoyu Zhou
    Citation: Immunity & Ageing 2024 21:15

    The Correction to this article has been published in Immunity & Ageing 2024 21:25

  27. The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of agin...

    Authors: Ruikai Liang, Xinrui Qi, Qi Cai, Liyan Niu, Xi Huang, Deju Zhang, Jitao Ling, Yuting Wu, Yixuan Chen, Pingping Yang, Jianping Liu, Jing Zhang and Peng Yu
    Citation: Immunity & Ageing 2024 21:14
  28. Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations observed in aging. It has...

    Authors: Ghazaleh Shimi, Mohammad Hassan Sohouli, Arman Ghorbani, Azam Shakery and Hamid Zand
    Citation: Immunity & Ageing 2024 21:13

    The Correction to this article has been published in Immunity & Ageing 2024 21:31

  29. In the context of the COVID-19 pandemic and extensive vaccination, it is important to explore the immune response of elderly adults to homologous and heterologous booster vaccines of COVID-19. At this point, w...

    Authors: Yuwei Zhang, Lianxiang Zhao, Jinzhong Zhang, Xiaomei Zhang, Shanshan Han, Qingshuai Sun, Mingxiao Yao, Bo Pang, Qing Duan and Xiaolin Jiang
    Citation: Immunity & Ageing 2024 21:11
  30. Age-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important roles in ovarian tissue homeostasis and immune surveillance. However, the impact of agi...

    Authors: Hui-Hui Shen, Xin-Yan Zhang, Nan Liu, Yang-Yang Zhang, Hui-Hua Wu, Feng Xie, Wen-Jun Wang and Ming-Qing Li
    Citation: Immunity & Ageing 2024 21:10
  31. Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is not only affect older people but can also occur in young individuals, ...

    Authors: Andrea Aprilia, Kusworini Handono, Hidayat Sujuti, Akhmad Sabarudin and Nuning Winaris
    Citation: Immunity & Ageing 2024 21:9
  32. The Disposable Soma Theory of aging suggests a trade-off between energy allocation for growth, reproduction and somatic maintenance, including immunity. While trade-offs between reproduction and immunity are w...

    Authors: Agathe Crosland, Thierry Rigaud, Charlène Develay and Yannick Moret
    Citation: Immunity & Ageing 2024 21:7
  33. The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convale...

    Authors: Janet M. Lord, Tonny Veenith, Jack Sullivan, Archana Sharma-Oates, Alex G. Richter, Neil J. Greening, Hamish J. C. McAuley, Rachael A. Evans, Paul Moss, Shona C. Moore, Lance Turtle, Nandan Gautam, Ahmed Gilani, Manan Bajaj, Louise V. Wain, Christopher Brightling…
    Citation: Immunity & Ageing 2024 21:6
  34. Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of aging. The bone marrow is the most important hematopoietic immune organ, ...

    Authors: Jianjie Lv, Chun Zhang, Xiuxing Liu, Chenyang Gu, Yidan Liu, Yuehan Gao, Zhaohao Huang, Qi Jiang, Binyao Chen, Daquan He, Tianfu Wang, Zhuping Xu and Wenru Su
    Citation: Immunity & Ageing 2024 21:3
  35. Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive d...

    Authors: Cristina Rodriguez-Rodriguez, Natalia González-Mancha, Ane Ochoa-Echeverría, Rosa Liébana and Isabel Merida
    Citation: Immunity & Ageing 2024 21:2
  36. Parkinson’s disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the degeneration of dopamine (DA) neurons. The prevalence of PD has experienced a significant surg...

    Authors: Bang-rong Wei, Yu-jia Zhao, Yu-feng Cheng, Chun Huang and Feng Zhang
    Citation: Immunity & Ageing 2024 21:1
  37. Coronavirus disease COVID-19 is a heterogeneous condition caused by SARS-CoV-2 infection. Generally, it is characterized by interstitial pneumonia that can lead to impaired gas-exchange, acute respiratory fail...

    Authors: Robertina Giacconi, Patrizia D’Aquila, Maurizio Cardelli, Francesco Piacenza, Elisa Pierpaoli, Giada Sena, Mirko Di Rosa, Anna Rita Bonfigli, Roberta Galeazzi, Antonio Cherubini, Massimiliano Fedecostante, Riccardo Sarzani, Chiara Di Pentima, Piero Giordano, Roberto Antonicelli, Fabrizia Lattanzio…
    Citation: Immunity & Ageing 2023 20:76

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