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  1. Research

    The anti-ageing molecule sirt1 mediates beneficial effects of cardiac rehabilitation

    An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodyna...

    Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A. Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli and Valeria Conti

    Immunity & Ageing 2017 14:7

    Published on: 16 March 2017

  2. Research

    CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women

    The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears...

    Silvana Mara Turbino Luz Ribeiro, Laís Roquete Lopes, Guilherme de Paula Costa, Vivian Paulino Figueiredo, Deena Shrestha, Aline Priscila Batista, Roney Luiz de Carvalho Nicolato, Fernando Luiz Pereira de Oliveira, Juliana Assis Silva Gomes and Andre Talvani

    Immunity & Ageing 2017 14:6

    Published on: 11 March 2017

  3. Research

    Changes in peripheral immune cell numbers and functions in octogenarian walkers – an acute exercise study

    Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral ...

    Kornelis S. M. van der Geest, Qi Wang, Thijs M. H. Eijsvogels, Hans J. P. Koenen, Irma Joosten, Elisabeth Brouwer, Maria T. E. Hopman, Joannes F. M. Jacobs and Annemieke M. H. Boots

    Immunity & Ageing 2017 14:5

    Published on: 22 February 2017

  4. Research

    Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals

    Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytok...

    Gabriela Silveira-Nunes, Elaine Speziali, Andréa Teixeira-Carvalho, Danielle M. Vitelli-Avelar, Renato Sathler-Avelar, Taciana Figueiredo-Soares, Maria Luiza Silva, Vanessa Peruhype-Magalhães, Daniel Gonçalves Chaves, Gustavo Eustáquio Brito-Melo, Glenda Meira Cardoso, Eric Bassetti Soares, Silvana Maria Elói-Santos, Rosângela Teixeira, Dulciene Magalhães Queiroz, Rodrigo Corrêa-Oliveira…

    Immunity & Ageing 2017 14:2

    Published on: 23 January 2017

  5. Research

    Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors

    NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression...

    Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda and Zbigniew Kmieć

    Immunity & Ageing 2017 14:3

    Published on: 23 January 2017

  6. Research

    A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

    Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Conseq...

    E. Vianello, E. Dozio, A. Barassi, G. Sammarco, L. Tacchini, M. M. Marrocco-Trischitta, S. Trimarchi and M. M. Corsi Romanelli

    Immunity & Ageing 2017 14:1

    Published on: 5 January 2017

  7. Research

    Frailty has a stronger association with inflammation than age in older veterans

    Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the ...

    P. Van Epps, D. Oswald, P. A. Higgins, T. R. Hornick, H. Aung, R. E. Banks, B. M. Wilson, C. Burant, S. Gravenstein and D. H. Canaday

    Immunity & Ageing 2016 13:27

    Published on: 19 October 2016

    The Erratum to this article has been published in Immunity & Ageing 2017 14:4

  8. Short report

    Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults

    We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals....

    Marco Grasse, Andreas Meryk, Michael Schirmer, Beatrix Grubeck-Loebenstein and Birgit Weinberger

    Immunity & Ageing 2016 13:26

    Published on: 5 September 2016

  9. Review

    The inflammatory protein Pentraxin 3 in cardiovascular disease

    The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate...

    Francesco Fornai, Albino Carrizzo, Maurizio Forte, Mariateresa Ambrosio, Antonio Damato, Michela Ferrucci, Francesca Biagioni, Carla Busceti, Annibale A. Puca and Carmine Vecchione

    Immunity & Ageing 2016 13:25

    Published on: 24 August 2016

  10. Research

    Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors

    Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stabl...

    Yun Lin, Jiewan Kim, E. Jeffrey Metter, Huy Nguyen, Thai Truong, Ana Lustig, Luigi Ferrucci and Nan-ping Weng

    Immunity & Ageing 2016 13:24

    Published on: 18 August 2016

  11. Research

    Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis

    There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have lon...

    A. Trovato, R. Siracusa, R. Di Paola, M. Scuto, M. L. Ontario, Ornella Bua, Paola Di Mauro, M. A. Toscano, C. C. T. Petralia, L. Maiolino, A. Serra, S. Cuzzocrea and Vittorio Calabrese

    Immunity & Ageing 2016 13:23

    Published on: 9 July 2016

  12. Research

    Elastic band resistance training influences transforming growth factor-ß receptor I mRNA expression in peripheral mononuclear cells of institutionalised older adults: the Vienna Active Ageing Study (VAAS)

    Ageing, inactivity and obesity are associated with chronic low-grade inflammation contributing to a variety of lifestyle-related diseases. Transforming growth factor-β (TGF-β) is a multimodal protein with vari...

    Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Bernhard Franzke, Thomas Wolf, Eva-Maria Strasser, Norbert Bachl, Michael Quittan, Karl-Heinz Wagner and Barbara Wessner

    Immunity & Ageing 2016 13:22

    Published on: 30 June 2016

  13. Research

    Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

    In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and ol...

    Monika Puzianowska-Kuźnicka, Magdalena Owczarz, Katarzyna Wieczorowska-Tobis, Pawel Nadrowski, Jerzy Chudek, Przemyslaw Slusarczyk, Anna Skalska, Marta Jonas, Edward Franek and Malgorzata Mossakowska

    Immunity & Ageing 2016 13:21

    Published on: 3 June 2016

  14. Research

    The prognostic value of biomarkers in stroke

    Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The “Triage® Stroke...

    Francesco Iemolo, Enzo Sanzaro, Giovanni Duro, Antonello Giordano and Maurizio Paciaroni

    Immunity & Ageing 2016 13:19

    Published on: 31 May 2016

  15. Research

    Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes

    Over the past fifteen years, we have demonstrated that cortisol and dehydroepiandrosterone (DHEA) have opposite effects on the regulation of protein kinase C (PKC) activity in the context of the immune system....

    Emanuela Corsini, Valentina Galbiati, Angela Papale, Elena Kummer, Antonella Pinto, Melania M. Serafini, Antonio Guaita, Roberto Spezzano, Donatella Caruso, Marina Marinovich and Marco Racchi

    Immunity & Ageing 2016 13:20

    Published on: 29 May 2016

  16. Editorial

    Nutrigerontology: a key for achieving successful ageing and longevity

    During the last two centuries the average lifespan has increased at a rate of approximately 3 months/year in both sexes, hence oldest old people are becoming the population with the fastest growth in Western W...

    Anna Aiello, Giulia Accardi, Giuseppina Candore, Giuseppe Carruba, Sergio Davinelli, Giuseppe Passarino, Giovanni Scapagnini, Sonya Vasto and Calogero Caruso

    Immunity & Ageing 2016 13:17

    Published on: 21 May 2016

  17. Research

    Effects of thermal water inhalation in chronic upper respiratory tract infections in elderly and young patients

    Chronic upper respiratory tract infections (cURTI) are very frequent illnesses which occur at any age of life. In elderly, cURTI are complicated by immunosenescence, with involvement of lung immune responsiven...

    Thea Magrone, Mauro Galantino, Nunzio Di Bitonto, Luisella Borraccino, Gerardo Chiaromonte and Emilio Jirillo

    Immunity & Ageing 2016 13:18

    Published on: 5 May 2016

  18. Review

    Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

    An extensive literature describes the positive impact of dietary phytochemicals on overall health and longevity. Dietary phytochemicals include a large group of non-nutrients compounds from a wide range of pla...

    Sergio Davinelli, Michael Maes, Graziamaria Corbi, Armando Zarrelli, Donald Craig Willcox and Giovanni Scapagnini

    Immunity & Ageing 2016 13:16

    Published on: 14 April 2016

  19. Research

    β-glucans: ex vivo inflammatory and oxidative stress results after pasta intake

    It is well known that Mediterranean Diet can positively influence the health of each individual, in particular it is know that fibers have an important role. However, in Mediterranean cities most people do not...

    Annalisa Barera, Silvio Buscemi, Roberto Monastero, Calogero Caruso, Rosalia Caldarella, Marcello Ciaccio and Sonya Vasto

    Immunity & Ageing 2016 13:14

    Published on: 7 April 2016

  20. Review

    Nutrition, aging and cancer: lessons from dietary intervention studies

    There is convincing epidemiological and clinical evidence that, independent of aging, lifestyle and, notably, nutrition are associated with development or progression of major human cancers, including breast, ...

    Giuseppe Carruba, Letizia Cocciadiferro, Antonietta Di Cristina, Orazia M. Granata, Cecilia Dolcemascolo, Ildegarda Campisi, Maurizio Zarcone, Maria Cinquegrani and Adele Traina

    Immunity & Ageing 2016 13:13

    Published on: 7 April 2016

  21. Review

    Human longevity: Genetics or Lifestyle? It takes two to tango

    Healthy aging and longevity in humans are modulated by a lucky combination of genetic and non-genetic factors. Family studies demonstrated that about 25 % of the variation in human longevity is due to genetic ...

    Giuseppe Passarino, Francesco De Rango and Alberto Montesanto

    Immunity & Ageing 2016 13:12

    Published on: 5 April 2016

  22. Research

    Nutraceutical effects of table green olives: a pilot study with Nocellara del Belice olives

    The aim of this study was to analyse the nutraceutical properties of table green olives Nocellara del Belice, a traditional Mediterranean food. The Mediterranean Diet has as key elements olives and extra virgin o...

    Giulia Accardi, Anna Aiello, Valeria Gargano, Caterina Maria Gambino, Santo Caracappa, Sandra Marineo, Gesualdo Vesco, Ciriaco Carru, Angelo Zinellu, Maurizio Zarcone, Calogero Caruso and Giuseppina Candore

    Immunity & Ageing 2016 13:11

    Published on: 5 April 2016

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