Table 1 Summary of the RCTs using PRP in tooth extraction
From: Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration
Authors | Year of publication | Number of patients | Follow-up (wks) | Main results | Effect of PRP |
|---|---|---|---|---|---|
Alissa et al. | 2010 | 23 | 12 | Statistical significant improvement in soft and bone tissuehealing; statistically significant reduced post-operative pain and complications | strong |
Ogundipe et al. | 2011 | 11 | 12 | Statistical significantly reduced pain; improvement in swelling/interincisal mouth opening and bone density but not statistically significant | moderate |
Ruktowski et al. | 2010 | 12 | 25 | Early and significant increased radiographic density over baseline measurements in PRP- treated sites; no significant improvement in post-operative pain and bleeding after PRP application. | moderate |
Celio-Mariano et al. | 2012 | 15 | 1-4-8-12-24 | Significant improvement in bone healing in PRP- treated sites | strong |
Arenaz-Bua et al. | 2012 | 82 | 12-24 | No acceleration of bone formation after PRP treatment. No improvement in pain, swelling, trismus and infection. | weak |
Gurbuzer et al. | 2008 | 12 | 1-4 | No increased osteoblastic activity in PRP treated sites | weak |