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Editors' Pick: Mysterious miRs

Of the complex pathways regulating T cell production, development, activation, differentiation, efector function and ageing, miRs have recently gained prominence in the eyes of immunogerontologists. A prime mover in this respect is miR-181a, the expression of which is dynamically regulated during the T cell life cycle, from development in the thymus to differentiation and eventually aging in the periphery. In their review paper, “miR-181a-regulated pathways in T-cell differentiation and aging”, Kim, Ye, Weyand and Goronzy demystify the central function of this miR-181 family member, explaining the unique role of miR-181a in T cell development, T cell activation and antiviral T cell responses, the mechanisms causing its age-related decline and the potential of restoring its expression or targeting it to rejuvenate T cell responses in older people.


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Thematic series: Immunity, Metabolism and Aging

Due to the cancellation of the meeting “Immunity, Metabolism and Aging”, scheduled to take place in Modena (Italy), September 24-25 2020, for the difficult circumstances created by the global COVID-19 pandemic, we have suggested a "Symposium-in-Writing" whereby the speakers that have already accepted to give a talk in Modena will submit a paper to this special issue of the journal Immunity & Ageing. Daniela Frasca and Andrea Cossarizza

Thematic series: Towards Biomarkers of Human Immunosenescence

‘Immunosenescence’ describes the multifactorial changes in the immune system with advanced age. To increase our understanding of the conditions of immune function in aging, the focus of this special issue is to document biomarkers of age-related immune conditions. We seek articles which highlight validated biomarkers or approaches to quantify immune aging, clarify heterogeneity among changes that accrue in aging, identify mechanisms underlying the altered state, or highlight where interventions may serve to improve health.  Articles may be commentaries or original research. Articles especially welcomed will address conceptual topics, detectable biomarkers, or clinical implications.

COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

Announcing the launch of In Review

Immunity & Ageing, in partnership with Research Square, is now offering In Review. Authors choosing this free optional service will be able to:

  • Share their work with fellow researchers to read, comment on, and cite even before publication
  • Showcase their work to funders and others with a citable DOI while it is still under review
  • Track their manuscript - including seeing when reviewers are invited, and when reports are received 

Articles

2021

Thematic series
Towards Biomarkers of Human Immunosenescense
Ruth Montgomery and Alan Cohen


2020

Thematic series
Immunity, Metabolism and Aging
Daniela Frasca and Andrea Cossarizza


2016

Thematic series
Nutrigerontology: a key for achieving successful ageing and longevity
Collection published: April/ May 2016


2015

Cross journal collection
Day of Immunology 2015
Collection published: 28 April 2015


2012

Thematic series
Positive biology: the centenarian lesson
Immunity & Ageing
Collection published: 23 April 2012

Aims and scope

The increasing realization that immune ageing and organismal ageing are intimately inter-related puts the immune system at centre-stage in our efforts to understand and manipulate the ageing process.

Immunity & Ageing provides a specific conduit for dissemination of new knowledge in this increasingly important arena. Published since 2004, the journal is a specialist open access journal dedicated to promulgating information on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases which have at least partly an immune etiology, and potential immune interventions to increase health span.

Immunity & Ageing welcomes submissions dealing with any aspect of ageing in human and model organisms that relates to immune function.  Papers dealing with any aspect of ageing that does not include a substantial immunological element will not be considered.

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About the Editors

Graham Pawelec

Graham Pawelec is Professor of Experimental Immunology at the University of Tübingen, Germany, where he led the Tübingen Ageing and Tumour Immunology (TATI) group from 1999 to 2017. He is currently affiliated with the Health Sciences North Research Institute of Canada, Sudbury, ON, and is a Visiting Professor at Nottingham Trent University, King´s College London, and Manchester University, UK. His research interests remain centered on immunogerontology in the context of cancer immunology and immunotherapy, and vaccination.

Nan-ping Weng

Nan-ping Weng is tenured senior investigator, Chief of Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology at the National Insitute on Aging (NIA), NIH. He joined the Laboratory of Immunology at the NIA as a tenure-track investigator in 1997 and has been tenured senior investigator since 2006. His laboratory focuses on the understanding of molecular and cellular mechanisms of T cell differentiation and age-associated decline of T cell functions.

Founding Editor

Professor Calogero Caruso MD Professor of General Pathology and Director of Palermo University Medical School “Ippocrate”

Whether your interests are immunological aspects of ageing, age-related diseases and longevity, this journal can serve as an appropriate venue.

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