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Editors' pick: Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics

Mutations accumulate in multiple tissues with age, but can be challenging to quantify. Blood is an easily accessible tissue in which clonal hematopoiesis can be documented. This is an age-related expansion of a mutant hematopoietic stem cell (HSC) arbitrarily defined as >2% of the blood cells. This phenomenon rarely occurs in younger people under 40, but is present in 10-20% of those over 70 and may even reach essentially 100% in the oldest old. It is clinically important because it is associated with an increased incidence of myeloid dysplasias that may become malignant, as well as cardiovascular disease. However, because of the complexity and cost of analytic methods such as whole-exome or genome sequencing, most investigations thus far have been cross-sectional, with all the limitations of such studies. However, Uddin et al. have now developed a new method to overcome this difficulty and present a longitudinal study tracking the nature and fate of clonal HSC expansions over a 16-year period covering late middle-age to old age. Such studies will provide important information on the clinical implications of differences in clonal mutational dynamics in diverse populations under different conditions.


https://immunityageing.biomedcentral.com/articles/10.1186/s12979-022-00278-9



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Topical Collection: Immunobiology of the mucosal system

New Content ItemMucosal immunology is the study of immune responses of the oral, lung, intestine and urogenital areas of the body. The mucosal environment as well the microbiome interacts with the immune system to have a profound effect. Advancing age is characterized by susceptibility to infections and other diseases of the mucosa. An example is the recent COVID-19 pandemic. We seek articles on all aspects of mucosal immunology and aging including increase incidence in infectious diseases, changes in the microbiome, mucosal vaccines and delivery systems, age-related changes in regeneration and repair mechanisms as well as clinical articles. Articles may be commentaries or original research.

Topical collection: Comparative Immunosenescence

New Content ItemOur knowledge of the negative consequences of the important differences of immune function seen in younger and older individuals is scarce, and mostly limited to humans, mice and to some extent monkeys and companion animals. However, comparative studies of the health impacts of immune ageing in other species, potentially including invertebrates, and in kingdoms other than animals, are scarcer still, but might shed light on some common features required for survival in a dangerous world. This Topical Collection accordingly aims to solicit papers on any aspect of immune ageing in species other than humans and mice. Reviews, original articles, commentaries, hypotheses and opinion pieces are all very welcome.

Topical Collection: Towards Biomarkers of Human Immunosenescence

New Content Item‘Immunosenescence’ describes the multifactorial changes in the immune system with advanced age. To increase our understanding of the conditions of immune function in aging, the focus of this special issue is to document biomarkers of age-related immune conditions. We seek articles which highlight validated biomarkers or approaches to quantify immune aging, clarify heterogeneity among changes that accrue in aging, identify mechanisms underlying the altered state, or highlight where interventions may serve to improve health.  Articles may be commentaries or original research. Articles especially welcomed will address conceptual topics, detectable biomarkers, or clinical implications.

Topical collection: Neuroimmunology and Ageing

New Content ItemThis topical collection will explore how complex neuroimmune interactions promote healthy and pathological ageing. We seek reviews, viewpoints, commentaries, or original research articles exploring the role of stress, mood disorders, and sensory systems during normal and premature immunosenescence. Over the last few decades, increasing evidence is implicating a role for the immune system in brain physiology and behaviour. Therefore, we also welcome articles discussing the role of immune cells and cytokines for the ageing brain, as well as the role of inflammation in neuromuscular disorders associated with senescence. In addition, we seek articles exploring the role of immunosenescence in age-related pathologies of the nervous system, including neurodegenerative and autoimmune disorders (e.g., AD, PD and MS), as well as the role of vascular disease in neurodegeneration. In the context of the COVID-19 pandemic, we also seek articles discussing post-infectious degeneration in older adults.

Topical Collection: Immune response to Influenza virus and vaccine in old adults

New Content ItemSeasonal influenza is a common respiratory infection that causes significant health burden worldwide, particularly in older adults. Studies of altered immune functions with aging in human and animal model systems have identified underlying mechanisms and offer potential therapeutic insights. Vaccination is an effective tool to reduce and even prevent severe infection and its complications. Recent improvements in vaccine design enhance vaccine efficacy for at-risk older adults. Understanding innate, humoral and cellular conditions of the host immune system that contribute to severe infection and to age-associated alterations in vaccine response represent important steps in reducing the disease burden of influenza for the growing older adult population.

Announcing the launch of In Review

Immunity & Ageing, in partnership with Research Square, is now offering In Review. Authors choosing this free optional service will be able to:

  • Share their work with fellow researchers to read, comment on, and cite even before publication
  • Showcase their work to funders and others with a citable DOI while it is still under review
  • Track their manuscript - including seeing when reviewers are invited, and when reports are received 

Articles

2022

Topical collection
Immunobiology of the mucosal system
Anshu Agrawal

Topical collection
Comparative Immunosenescence
Graham Pawelec

Topical collection
Neuroimmunology and Ageing
Moisés E. Bauer and Roberto Paganelli

Topical collection
Immune response to Influenza virus and vaccine in old adults
Sean X. Leng and Albert Shaw


2021

Topical collection
Towards Biomarkers of Human Immunosenescense
Ruth Montgomery and Alan Cohen

2020

Topical collection
Immunity, Metabolism and Aging
Daniela Frasca and Andrea Cossarizza

2016

Topical collection
Nutrigerontology: a key for achieving successful ageing and longevity
Collection published: April/ May 2016

2015

Cross journal collection
Day of Immunology 2015
Collection published: 28 April 2015

2012

Topical collection
Positive biology: the centenarian lesson
Immunity & Ageing
Collection published: 23 April 2012

Aims and scope

The increasing realization that immune ageing and organismal ageing are intimately inter-related puts the immune system at centre-stage in our efforts to understand and manipulate the ageing process.

Immunity & Ageing provides a specific conduit for dissemination of new knowledge in this increasingly important arena. Published since 2004, the journal is a specialist open access journal dedicated to promulgating information on the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, age-associated diseases which have at least partly an immune etiology, and potential immune interventions to increase health span.

Immunity & Ageing welcomes submissions dealing with any aspect of ageing in human and model organisms that relates to immune function.  Papers dealing with any aspect of ageing that does not include a substantial immunological element will not be considered.

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About the Editors

Graham Pawelec

Graham Pawelec is Professor of Experimental Immunology at the University of Tübingen, Germany, where he led the Tübingen Ageing and Tumour Immunology (TATI) group from 1999 to 2017. He is currently affiliated with the Health Sciences North Research Institute of Canada, Sudbury, ON, and is a Visiting Professor at Nottingham Trent University, King´s College London, and Manchester University, UK. His research interests remain centered on immunogerontology in the context of cancer immunology and immunotherapy, and vaccination.

Nan-ping Weng

Nan-ping Weng is tenured senior investigator, Chief of Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology at the National Insitute on Aging (NIA), NIH. He joined the Laboratory of Immunology at the NIA as a tenure-track investigator in 1997 and has been tenured senior investigator since 2006. His laboratory focuses on the understanding of molecular and cellular mechanisms of T cell differentiation and age-associated decline of T cell functions.

Founding Editor

Professor Calogero Caruso MD Professor of General Pathology and Director of Palermo University Medical School “Ippocrate”

Whether your interests are immunological aspects of ageing, age-related diseases and longevity, this journal can serve as an appropriate venue.

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