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Editors' pick: Genetic and environmental determinants of human TCR repertoire diversity

As people age and are increasingly exposed to internal and external immune challenges, the T cell antigen receptor repertoire changes to reflect memory of these challenges and the diversity of the repertoire decreases. The TCR recognizes antigens in association with HLA molecules. The HLA system is the most genetically polymorphic complex known, but its impact on the diversity of the TCR repertoire has remained unclear until now. This paper shows that TCR repertoire diversity is positively associated with polymorphism at HLA-I, but decreases with increasing age and cytomegalovirus infection, which shape the repertoire in healthy individuals. These observations reflect the mechanism responsible for the evolutionary advantage of HLA polymorphism, as long suspected but not documented until now.

Thematic series: Immunity, Metabolism and Aging

Due to the cancellation of the meeting “Immunity, Metabolism and Aging”, scheduled to take place in Modena (Italy), September 24-25 2020, for the difficult circumstances created by the global COVID-19 pandemic, we have suggested a "Symposium-in-Writing" whereby the speakers that have already accepted to give a talk in Modena will submit a paper to this special issue of the journal Immunity & Ageing. Daniela Frasca and Andrea Cossarizza

COVID-19 and impact on peer review

As a result of the significant disruption that is being caused by the COVID-19 pandemic we are very aware that many researchers will have difficulty in meeting the timelines associated with our peer review process during normal times.  Please do let us know if you need additional time. Our systems will continue to remind you of the original timelines but we intend to be highly flexible at this time.

Announcing the launch of In Review

Immunity & Ageing, in partnership with Research Square, is now offering In Review. Authors choosing this free optional service will be able to:

  • Share their work with fellow researchers to read, comment on, and cite even before publication
  • Showcase their work to funders and others with a citable DOI while it is still under review
  • Track their manuscript - including seeing when reviewers are invited, and when reports are received 

Articles

2020

Thematic series
Immunity, Metabolism and Aging
Daniela Frasca and Andrea Cossarizza


2016

Thematic series
Nutrigerontology: a key for achieving successful ageing and longevity
Collection published: April/ May 2016


2015

Cross journal collection
Day of Immunology 2015
Collection published: 28 April 2015


2012

Thematic series
Positive biology: the centenarian lesson
Immunity & Ageing
Collection published: 23 April 2012

Aims and scope

Immunity & Ageing, published since 2004, is a specialist open access journal dedicated to increasing knowledge about the impact of ageing on immune systems, the influence of aged immune systems on organismal well-being and longevity, and the potential for interventions to increase lifespan. The journal welcomes submissions dealing with any aspect of ageing in human and model organisms that relates to immune function.

All articles undergo rapid and rigorous peer-review and all accepted articles are published open access to provide the highest visibility for authors’ work.

The increasing realization that immune ageing and organismal ageing are intimately inter-related puts the immune system centre-stage in our efforts to understand and manipulate the ageing process and Immunity & Ageing continues to offer a specialized conduit for dissemination of new knowledge in this increasingly important arena.

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About the Editors

Graham Pawelec

Graham Pawelec is Professor of Experimental Immunology at the University of Tübingen, Germany, where he led the Tübingen Ageing and Tumour Immunology (TATI) group from 1999 to 2017. He is currently affiliated with the Health Sciences North Research Institute of Canada, Sudbury, ON, and is a Visiting Professor at Nottingham Trent University, King´s College London, and Manchester University, UK. His research interests remain centered on immunogerontology in the context of cancer immunology and immunotherapy, and vaccination.

Nan-ping Weng

Nan-ping Weng is tenured senior investigator, Chief of Lymphocyte Differentiation Section, Laboratory of Molecular Biology and Immunology at the National Insitute on Aging (NIA), NIH. He joined the Laboratory of Immunology at the NIA as a tenure-track investigator in 1997 and has been tenured senior investigator since 2006. His laboratory focuses on the understanding of molecular and cellular mechanisms of T cell differentiation and age-associated decline of T cell functions.

Founding Editor

Professor Calogero Caruso MD Professor of General Pathology and Director of Palermo University Medical School “Ippocrate”

Whether your interests are immunological aspects of ageing, age-related diseases and longevity, this journal can serve as an appropriate venue.

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