Articles

The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study

Older age could be a risk factor for suboptimal CD4+ T-cell recovery in HIV-infected patients despite successful viral suppression. However, evaluation of this effect could be confounded by age-related immune ...

Authors: Jingxian Chen, Kehmia Titanji, Anandi N. Sheth, Rajesh Gandhi, Deborah McMahon, Ighovwerha Ofotokun, M. Neale Weitzmann, Kristina De Paris and Julie B. Dumond

Knockdown of lncRNA BDNF-AS inhibited the progression of multiple myeloma by targeting the miR-125a/b-5p-BCL2 axis

This study aimed to explore the role of long non-coding RNA (lncRNA) BDNF-AS in the progression of multiple myeloma (MM).

Authors: Min Chu, Yingchao Fan, Liting Wu, Xiaoyan Ma, Jinfeng Sao, Yonghua Yao, Wenfang Zhuang and Cui Zhang

The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells

Memory B cells are an antigen-experienced B-cell population with the ability to rapidly differentiate into antibody-producing cells by recall responses. We recently found that dedicator of cytokinesis 11 (DOCK...

Authors: Yuma Sugiyama, Mitsuhiro Fujiwara, Akihiko Sakamoto, Hiromichi Tsushima, Akihiko Nishikimi and Mitsuo Maruyama

Association of immunity markers with the risk of incident frailty: the Rugao longitudinal aging study

The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) are readily available circulatory immunity markers that are associated with components ...

Authors: Hui Zhang, Meng Hao, Zixin Hu, Yi Li, Xiaoyan Jiang, Jiucun Wang, Li Jin, Zuyun Liu, Xiaofeng Wang and Xuehui Sun

MicroRNA-425-5p modulates osteoporosis by targeting annexin A2

Studies have shown that the decrease of osteogenic differentiation of bone marrow mesenchymal stem cells (MSC) is an important mechanism of osteoporosis. The object of this study was to explore the role and me...

Authors: Guanghua Chen, Guizhi Huang, Han Lin, Xinyou Wu, Xiaoyan Tan and Zhoutao Chen

Quantification of dendritic cell subsets in human thymus tissues of various ages

Dendritic cells (DCs) in the thymus are involved in central tolerance formation, but they also have other functions in the thymus, such as pathogen recognition. The density changes of human thymic DCs have bee...

Authors: Yan Li, Pei Chen, Hao Huang, Huiyu Feng, Hao Ran and Weibin Liu

Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation

The incidence of kidney transplantation performed in elderly patients has increased steadily recently. Higher risk of infection and mortality, but lower rate of rejection, are reported in older kidney transpla...

Authors: Lei Wang, Christien Rondaan, Anoek A. E. de Joode, Elisabeth Raveling-Eelsing, Nicolaas A. Bos and Johanna Westra

Loss of toll-like receptor 4 ameliorates cardiovascular dysfunction in aged mice

Toll-like receptor 4 (TLR4) is a pattern recognition receptor of the innate immune system. TLR4 contributes to many aging-related chronic diseases. However, whether TLR4 is involved in cardiovascular injury du...

Authors: Huan Liu, Shujuan Chu and Zhilin Wu

Multiple thymi and no thymic involution in naked mole rats?

Authors: Graham Pawelec

SARS-CoV-2 and EBV; the cost of a second mitochondrial “whammy”?

We, and others, have suggested that as the SARS-CoV-2 virus may modulate mitochondrial function, good mitochondrial reserve and health could be key in determining disease severity when exposed to this virus, a...

Authors: Alistair V.W. Nunn, Geoffrey W. Guy, Stanley W. Botchway and Jimmy D. Bell

Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age

Authors: Rachel H. McMahan, Kevin M. Najarro, Juliet E. Mullen, Madison T. Paul, David J. Orlicky, Holly J. Hulsebus and Elizabeth J. Kovacs

Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond

Preserving good health in old age is of utmost importance to alleviate societal, economic and health care-related challenges caused by an aging society. The prevalence and severity of many infectious diseases ...

Authors: Birgit Weinberger

A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age

There are currently > 600 million people over the age of 65 globally and this number is expected to double by the year 2050. Alcohol use among this population is on the rise, which is concerning as aging is as...

Authors: Rachel H. McMahan, Kevin M. Najarro, Juliet E. Mullen, Madison T. Paul, David J. Orlicky, Holly J. Hulsebus and Elizabeth J. Kovacs

Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings

The rapidity of SARS-CoV-2 vaccination around the world has substantially reduced the number of new cases of COVID-19 and their severity in highly vaccinated countries. The unanticipated efficacy of SARS-CoV-2...

Authors: Nan-ping Weng and Graham Pawelec

Metabolic phenotype of B cells from young and elderly HIV individuals

HIV infection induces inflammaging and chronic immune activation (IA), which are negatively associated with protective humoral immunity. Similar to HIV, aging is also associated with increased inflammaging and...

Authors: Daniela Frasca, Suresh Pallikkuth and Savita Pahwa

Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people

Several SARS-CoV-2 vaccines have shown clinical efficacy against Covid-19 infection but there remains uncertainty about the immune responses elicited by different regimens. This is a particularly important que...

Authors: Helen Parry, Rachel Bruton, Christine Stephens, Kevin Brown, Gayatri Amirthalingam, Ashley Otter, Bassam Hallis, Jianmin Zuo and Paul Moss

May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?

This study aimed to identify novel plasma metabolic signatures with possible clinical relevance during the aging process. A biochemical quantitative phenotyping platform, based on targeted electrospray ionizat...

Authors: Ismael Dale Cotrim Guerreiro da Silva, Dirce Maria Lobo Marchioni, Antonio Augusto Ferreira Carioca, Valquiria Bueno and Gisele Wally Braga Colleoni

Correction to: Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults

Authors: David C. LaFon, Steffen Thiel, Young-il Kim, Mark T. Dransfield and Moon H. Nahm

Does immunosenescence drive organismal ageing via inflammageing?

Authors: Graham Pawelec

A description of the relationship in healthy longevity and aging-related disease: from gene to protein

Human longevity is a complex phenotype influenced by both genetic and environmental factors. It is also known to be associated with various types of age-related diseases, such as Alzheimer’s disease (AD) and c...

Authors: Xiaolin Ni, Zhaoping Wang, Danni Gao, Huiping Yuan, Liang Sun, Xiaoquan Zhu, Qi Zhou and Ze Yang

Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related...

Authors: Usma Munawara, Michael Catanzaro, Weili Xu, Crystal Tan, Katsuiku Hirokawa, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque, Charles Ramassamy, Annelise E. Barron, Stephen Cunnane, Pascale B. Beauregard, Jean-Pierre Bellenger, Serafim Rodrigues…

miR-181a-regulated pathways in T-cell differentiation and aging

MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells,...

Authors: Chulwoo Kim, Zhongde Ye, Cornelia M. Weyand and Jörg J. Goronzy

Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing

Osteoarthritis (OA) is one of the most prevalent joint diseases of advanced age and is a leading cause of disability worldwide. Ageing is a major risk factor for the articular cartilage (AC) degeneration that ...

Authors: Seth D. Thompson, Rajeswari Pichika, Richard L. Lieber and Mitra Lavasani

Is mechanical loading essential for exercise to preserve the aging immune system?

Authors: Richard J. Simpson and Graham Pawelec

A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases

Elderly patients with cardiovascular diseases account for a large proportion of Corona virus Disease 2019(COVID-19)related deaths. COVID-19, as a new coronavirus, mainly targets the patient’s lung triggering a...

Authors: Yuanyuan Wang, Shu-Chao Pang and Ying Yang

The age again in the eye of the COVID-19 storm: evidence-based decision making

One hundred fifty million contagions, more than 3 million deaths and little more than 1 year of COVID-19 have changed our lives and our health management systems forever. Ageing is known to be one of the signi...

Authors: María C. Martín, Aurora Jurado, Cristina Abad-Molina, Antonio Orduña, Oscar Yarce, Ana M. Navas, Vanesa Cunill, Danilo Escobar, Francisco Boix, Sergio Burillo-Sanz, María C. Vegas-Sánchez, Yesenia Jiménez-de las Pozas, Josefa Melero, Marta Aguilar, Oana Irina Sobieschi, Marcos López-Hoyos…

Functional conservation in genes and pathways linking ageing and immunity

At first glance, longevity and immunity appear to be different traits that have not much in common except the fact that the immune system promotes survival upon pathogenic infection. Substantial evidence howev...

Authors: Daniel K. Fabian, Matías Fuentealba, Handan Melike Dönertaş, Linda Partridge and Janet M. Thornton

Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

An amendment to this paper has been published and can be accessed via the original article.

Authors: Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch and Andreas Thiel

CMV infection, CD19⁺ B cell depletion, and Lymphopenia as predictors for unexpected admission in the institutionalized elderly

Chronic infections played a detrimental role on health outcomes in the aged population, and had complex associations with lymphocyte subsets distribution. Our study aimed to explore the predictive roles of chr...

Authors: Liang-Yu Chen, An-Chun Hwang, Chung-Yu Huang, Liang-Kung Chen, Fu-Der Wang and Yu-Jiun Chan

High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

Immune ageing is a result of repetitive microbial challenges along with cell intrinsic or systemic changes occurring during ageing. Mice under ‘specific-pathogen-free’ (SPF) conditions are frequently used to a...

Authors: Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch and Andreas Thiel

Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans

The impact of aging on the immune system is unequivocal and results in an altered immune status termed immunosenescence. In humans, the mechanisms of immunosenescence have been examined almost exclusively in b...

Authors: Jayaum S. Booth, Eric Goldberg, Seema A. Patil, Robin S. Barnes, Bruce D. Greenwald and Marcelo B. Sztein

An evaluation of the recognised systemic inflammatory biomarkers of chronic sub-optimal inflammation provides evidence for inflammageing (IFA) during multiple sclerosis (MS)

The pathogenesis of the human demyelinating disorder multiple sclerosis (MS) involves the loss of immune tolerance to self-neuroantigens. A deterioration in immune tolerance is linked to inherent immune ageing...

Authors: Christopher Bolton

Analysis of the heterogeneity of the BCR H-CDR3 repertoire in the bone marrow and spleen of 3-, 12-, and 20-month old mice

The number of central and peripheral B cells and their responsiveness are decreased in aged mice. The diversity of mice central and peripheral B cell repertoires with increasing age has not been elucidated. In...

Authors: Lina Ma, Xinxin Tao, Xiaoyan He, Peng Wang, Long Ma, Bin Shi and Xinsheng Yao

Local immune responses to tuberculin skin challenge in Mycobacterium bovis BCG-vaccinated baboons: a pilot study of younger and older animals

Individuals over the age of 65 are highly susceptible to infectious diseases, which account for one-third of deaths in this age group. Vaccines are a primary tool to combat infection, yet they are less effecti...

Authors: Julia M. Scordo, Tucker J. Piergallini, Nicole Reuter, Colwyn A. Headley, Vida L. Hodara, Olga Gonzalez, Luis D. Giavedoni, James F. Papin and Joanne Turner

Hypothetical COVID-19 protection mechanism: hints from centenarians

The risk of serious complications and the fatality rate due to COVID-19 pandemic have proven particularly higher in older persons, putting a further strain in healthcare system as we dramatically observed.

Authors: Franca Rosa Guerini, Matteo Cesari and Beatrice Arosio

Human endogenous retroviruses and ageing

Authors: Mikko Hurme and Graham Pawelec

Improving seasonal influenza vaccination for older adults

Authors: Graham Pawelec and Janet McElhaney

Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?

The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, an...

Authors: Cecilia Söderberg-Nauclér

Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children

Age-related changes in adaptive and innate immune cells have been associated with a decline in effective immunity and chronic, low-grade inflammation. Epigenetic, transcriptional, and functional changes in mon...

Authors: Katherine R. Dobbs, Paula Embury, Emmily Koech, Sidney Ogolla, Stephen Munga, James W. Kazura and Arlene E. Dent

Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls

Psoriasis vulgaris is a skin autoimmune disease. Psoriatic patients have significantly lowered life expectancy and suffer from various comorbidities. The main goal of the study was to determine whether psoriat...

Authors: Pavel Borsky, Marcela Chmelarova, Zdenek Fiala, Kvetoslava Hamakova, Vladimir Palicka, Jan Krejsek, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Martin Beranek, Andrea Malkova, Tereza Svadlakova, Drahomira Holmannova and Lenka Borska

Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities

Aging is associated with increased intrinsic B cell inflammation, decreased protective antibody responses and increased autoimmune antibody responses. The effects of aging on the metabolic phenotype of B cells...

Authors: Daniela Frasca, Maria Romero, Denisse Garcia, Alain Diaz and Bonnie B. Blomberg

T cells accumulate in non-diabetic islets during ageing

The resident immune population of pancreatic islets has roles in islet development, beta cell physiology, and the pathology of diabetes. These roles have largely been attributed to islet macrophages, comprisin...

Authors: Heather C. Denroche, Stéphanie Miard, Sandrine Sallé-Lefort, Frédéric Picard and C. Bruce Verchere

Unanticipated efficacy of SARS-CoV-2 vaccination in older adults

The rapidity with which vaccines against COVID-19 have been developed and tested is unprecedented. As classically the case with randomized clinical trials, many studies excluded older adults. However, given th...

Authors: Graham Pawelec and Janet McElhaney

Reduced immune-regulatory molecule expression on human colonic memory CD4 T cells in older adults

The etiology of the low-level chronic inflammatory state associated with aging is likely multifactorial, but a number of animal and human studies have implicated a functional decline of the gastrointestinal im...

Authors: Stephanie M. Dillon, Tezha A. Thompson, Allison J. Christians, Martin D. McCarter and Cara C. Wilson

Aging and CMV discordance are associated with increased immune diversity between monozygotic twins

Broadly, much of variance in immune system phenotype has been linked to the influence of non-heritable factors rather than genetics. In particular, two non-heritable factors: aging and human cytolomegavirus (C...

Authors: Zheng Yan, Holden T. Maecker, Petter Brodin, Unni C. Nygaard, Shu Chen Lyu, Mark M. Davis, Kari C. Nadeau and Sandra Andorf

Macrophage function in the elderly and impact on injury repair and cancer

Older age is associated with deteriorating health, including escalating risk of diseases such as cancer, and a diminished ability to repair following injury. This rise in age-related diseases/co-morbidities is...

Authors: L Duong, HG Radley, B Lee, DE Dye, FJ Pixley, MD Grounds, DJ Nelson and C Jackaman

Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice

Physiological homeostasis decline, immunosenescence, and increased risk for multiple diseases, including neurodegeneration, are all hallmarks of ageing. Importantly, it is known that the ageing process is sex-...

Authors: Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, Janna Jernigan, Nikolay M. Filipov, Jessica M. Carpenter and Jae-Kyung Lee

Gut microbiota as the key controllers of “healthy” aging of elderly people

Extrinsic factors, such as lifestyle and diet, are shown to be essential in the control of human healthy aging, and thus, longevity. They do so by targeting at least in part the gut microbiome, a collection of...

Authors: Emeline Ragonnaud and Arya Biragyn

Obesity and COVID-19: what makes obese host so vulnerable?

The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symp...

Authors: Sameer Mohammad, Rafia Aziz, Saeed Al Mahri, Shuja Shafi Malik, Esraa Haji, Altaf Husain Khan, Tanvir Saleem Khatlani and Abderrezak Bouchama

T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II

Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiolog...

Authors: Julia Sbierski-Kind, David Goldeck, Nikolaus Buchmann, Joachim Spranger, Hans-Dieter Volk, Elisabeth Steinhagen-Thiessen, Graham Pawelec, Ilja Demuth and Dominik Spira