Articles

A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation

End-stage renal disease is associated with premature ageing of the T cell immune system but inter-individual variation is substantial. The hypothesis was tested that advanced immunological T cell ageing assess...

Authors: Michiel G. H. Betjes, Anton W. Langerak, Mariska Klepper and Nicolle H. R. Litjens

Age-related changes in T lymphocytes of patients with head and neck squamous cell carcinoma

The number of aging cancer patients has increased continuously and will do so further in the future. The immune system of elderly people experiences critical changes over the time. Therefore, tumor-induced cha...

Authors: S. S. Jeske, P. J. Schuler, J. Doescher, M. N. Theodoraki, S. Laban, C. Brunner, T. K. Hoffmann and M. C. Wigand

Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging

Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder. Immunosenes...

Authors: Rachel Thomas, Weikan Wang and Dong-Ming Su

Immune cell extracellular vesicles and their mitochondrial content decline with ageing

Although the mechanisms of action are not fully understood, extracellular vesicles (EVs) have emerged as key indicators and effectors of immune function. Characterizing circulating EVs associated with stem and...

Authors: Xin Zhang, Monica Jeanne Hubal and Virginia Byers Kraus

Network topology dynamics of circulating biomarkers and cognitive performance in older Cytomegalovirus-seropositive or -seronegative men and women

Cytokines are signaling molecules operating within complex cascade patterns and having exceptional modulatory functions. They impact various physiological processes such as neuroendocrine and metabolic interac...

Authors: Svetlana Di Benedetto, Ludmila Müller, Stefanie Rauskolb, Michael Sendtner, Timo Deutschbein, Graham Pawelec and Viktor Müller

Combined associations of hs-CRP and cognitive function with all-cause mortality among oldest-old adults in Chinese longevity areas: a prospective cohort study

Inflammatory markers, such as high sensitivity C-reactive protein (hs-CRP), and cognitive impairment (CI) are associated with mortality; CRP is related to the deterioration of CI. However, it is still unknown ...

Authors: Chen Chen, Yingchun Liu, Zhaojin Cao, Zhaoxue Yin, Feng Zhao, Yuebin Lv, Zuyun Liu, Chen Mao, Shixun Song, Ling Liu, Yingli Qu, Saisai Ji, Jun Duan, Jiaonan Wang, Virginia Byers Kraus, Yi Zeng…

Senescent synovial fibroblasts accumulate prematurely in rheumatoid arthritis tissues and display an enhanced inflammatory phenotype

Accumulation of senescent cells has been associated with pro-inflammatory effects with deleterious consequences in different human diseases. The purpose of this study was to analyze cell senescence in human sy...

Authors: Manuel J. Del Rey, Álvaro Valín, Alicia Usategui, Sandra Ergueta, Eduardo Martín, Cristina Municio, Juan D. Cañete, Francisco J. Blanco, Gabriel Criado and José L. Pablos

Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals

The association of high-sensitivity C-reactive protein (hsCRP) with mortality is controversial. We aimed to investigate the associations of hsCRP concentrations with the risks of all-cause and cause-specific m...

Authors: Zhi-Hao Li, Wen-Fang Zhong, Yue-Bin Lv, Virginia Byers Kraus, Xiang Gao, Pei-Liang Chen, Qing-Mei Huang, Jin-Dong Ni, Xiao-Ming Shi, Chen Mao and Xian-Bo Wu

Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge

Administered intramuscularly (IM), plant-derived, virus-like-particle (VLP) vaccines based on the influenza hemagglutinin (HA) protein elicit both humoral and cellular responses that can protect aged mice from...

Authors: Breanna Hodgins, Stephane Pillet, Nathalie Landry and Brian J. Ward

Lymphocyte homeostasis is maintained in perinatally HIV-infected patients after three decades of life

While immunosenescence, defined as reduced production of new lymphocytes, restriction of T-cell receptor repertoire and telomeres shortening, has been extensively evaluated in HIV-infected children and adults,...

Authors: S. Paghera, E. Quiros-Roldan, A. Sottini, M. Properzi, F. Castelli and L. Imberti

Immunosenescence and human vaccine immune responses

The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine res...

Authors: Stephen N. Crooke, Inna G. Ovsyannikova, Gregory A. Poland and Richard B. Kennedy

Age related human T cell subset evolution and senescence

T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage an...

Authors: Mingde Li, Danlin Yao, Xiangbo Zeng, Dimitri Kasakovski, Yikai Zhang, Shaohua Chen, Xianfeng Zha, Yangqiu Li and Ling Xu

AuNP-M2e + sCpG vaccination of juvenile mice generates lifelong protective immunity to influenza A virus infection

Influenza virus infection causes significant morbidity and mortality worldwide. Humans fail to make a universally protective memory response to influenza A because of high mutation rates in the immune-dominant...

Authors: Lynn Bimler, Amber Y. Song, Duy T. Le, Ashleigh Murphy Schafer and Silke Paust

The presence of CLL-associated stereotypic B cell receptors in the normal BCR repertoire from healthy individuals increases with age

Aging is known to induce immunosenescence, resulting in alterations in both the innate and adaptive immune system. Here we evaluated the effects of aging on B cell subsets in peripheral blood of 155 immunologi...

Authors: Alice F. Muggen, Madelon de Jong, Ingrid L. M. Wolvers-Tettero, Martine J. Kallemeijn, Cristina Teodósio, Nikos Darzentas, Ralph Stadhouders, Hanna IJspeert, Mirjam van der Burg, Wilfred FJ van IJcken, Jan A. N. Verhaar, Wayel H. Abdulahad, Elisabeth Brouwer, Annemieke M. H. Boots, Rudi W. Hendriks, Jacques J. M. van Dongen…

Peripheral antibody concentrations are associated with highly differentiated T cells and inflammatory processes in the human bone marrow

Antigen-experienced immune cells migrate back to the bone marrow (BM), where they are maintained in BM survival niches for an extended period. The composition of T cell subpopulations in the BM changes with ag...

Authors: Erin Naismith, Luca Pangrazzi, Marco Grasse, Michael Keller, Carina Miggitsch, Birgit Weinberger, Klemens Trieb and Beatrix Grubeck-Loebenstein

The transcriptome of peripheral blood mononuclear cells in patients with clinical subtypes of late age-related macular degeneration

Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clini...

Authors: Yousif Subhi, Marie Krogh Nielsen, Christopher Rue Molbech, Charlotte Liisborg, Helle Bach Søndergaard, Finn Sellebjerg and Torben Lykke Sørensen

CD27- IgD- B cell memory subset associates with inflammation and frailty in elderly individuals but only in males

Immunosenescence, i.e. the aging-associated decline of the capacity of the immune system, is characterized by several distinct changes in the number and functions of the immune cells. In the case of B cells, t...

Authors: Tapio Nevalainen, Arttu Autio, Laura Kummola, Tanja Salomaa, Ilkka Junttila, Marja Jylhä and Mikko Hurme

Systemic infection and microglia activation: a prospective postmortem study in sepsis patients

Systemic infection is associated with long-term cognitive deficits and functional decline. In this study we hypothesized that severe systemic inflammation leads to a neuroinflammatory response that is characte...

Authors: D. Westhoff, J. Y. Engelen-Lee, I. C. M. Hoogland, E. M. A. Aronica, D. J. van Westerloo, D. van de Beek and W. A. van Gool

Six weeks of strength endurance training decreases circulating senescence-prone T-lymphocytes in cytomegalovirus seropositive but not seronegative older women

Ageing is associated with a decline in immune function termed immunosenescence. This process is characterized amongst others by less naive T-cells and more senescent phenotypes, which have been implicated in t...

Authors: Hung Cao Dinh, Ivan Bautmans, Ingo Beyer, Oscar Okwudiri Onyema, Keliane Liberman, Liza De Dobbeleer, Wim Renmans, Sam Vander Meeren, Kristin Jochmans, Andreas Delaere, Veerle Knoop and Rose Njemini

Elevated urine IL-10 concentrations associate with Escherichia coli persistence in older patients susceptible to recurrent urinary tract infections

Age is a significant risk factor for recurrent urinary tract (rUTI) infections, but the clinical picture is often confused in older patients who also present with asymptomatic bacteriuria (ASB). Yet, how bacte...

Authors: Lauren K. L. Drage, Wendy Robson, Catherine Mowbray, Ased Ali, John D. Perry, Katherine E. Walton, Christopher Harding, Robert Pickard, Judith Hall and Phillip D. Aldridge

Inflammatory markers and bone health in postmenopausal women: a cross-sectional overview

Cytokines, chemokines, C-reactive proteins (CRP) and ferritin are known inflammatory markers. However, cytokines such as interleukin (IL-1β), (IL-6) and tumour necrosis factor (TNF-α) have been reported to int...

Authors: Bolaji Lilian Ilesanmi-Oyelere, Linda Schollum, Barbara Kuhn-Sherlock, Michelle McConnell, Sonya Mros, Jane Coad, Nicole C. Roy and Marlena Cathorina Kruger

Effect of homeostatic T-cell proliferation in the vaccine responsiveness against influenza in elderly people

Seasonal influenza virus infection is a significant cause of morbimortality in the elderly. However, there is poor vaccine efficacy in this population due to immunosenescence. We aimed to explore several homeo...

Authors: I. Herrero-Fernández, I. Rosado-Sánchez, A. I. Álvarez-Ríos, M. I. Galvá, M. De Luna-Romero, S. Sanbonmatsu-Gámez, M. Pérez-Ruiz, J. M. Navarro-Marí, A. Carrillo-Vico, B. Sánchez, R. Ramos, J. Cañizares, M. Leal and Y. M. Pacheco

Viruses and immunosenescence – more players in the game

Viral infections are common clinical problems in aged individuals often affecting both mortality and morbidity. The pathogenic mechanisms of the various viruses are not universal in aged individuals, i.e. the ...

Authors: Mikko Hurme

Topological DNA damage, telomere attrition and T cell senescence during chronic viral infections

T cells play a key role in controlling viral infections; however, the underlying mechanisms regulating their functions during human viral infections remain incompletely understood. Here, we used CD4 T cells de...

Authors: Yingjie Ji, Xindi Dang, Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Dechao Cao, Sushant Khanal, Madison Schank, Xiao Y. Wu, Zheng D. Morrison, Yue Zou, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman and Zhi Q. Yao

Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation

There is a growing interest in the role of inflammageing for chronic disease development. Cytokines are potent soluble immune mediators that can be used as target biomarkers of inflammageing; however, their me...

Authors: Liselot Koelman, Olga Pivovarova-Ramich, Andreas F. H. Pfeiffer, Tilman Grune and Krasimira Aleksandrova

RVG-modified exosomes derived from mesenchymal stem cells rescue memory deficits by regulating inflammatory responses in a mouse model of Alzheimer’s disease

Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs) derived exosomes have been demonstrated to prevent memory defi...

Authors: Guo-hong Cui, Hai-dong Guo, Han Li, Yu Zhai, Zhang-bin Gong, Jing Wu, Jian-sheng Liu, You-rong Dong, Shuang-xing Hou and Jian-ren Liu

Age-associated decrease in de novo donor-specific antibodies in renal transplant recipients reflects changing humoral immunity

Older age at organ transplantation is associated with increased risk of infection and malignancy but reduced risk of cellular rejection. De novo donor-specific anti-HLA antibodies (dnDSA), are key biomarkers asso...

Authors: Seraina von Moos, Gesa Schalk, Thomas F. Mueller and Guido Laube

Research on immunity and ageing comes of age

Ageing has a profound detrimental impact on almost all living organisms. Immune systems play a particularly important role in protection against external challenges (pathogens) and internal insults (cancer) bu...

Authors: Nan-ping Weng and Graham Pawelec

Lag-time in Alzheimer’s disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform

In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related r...

Authors: Luca Massaccesi, Emanuela Galliera, Daniela Galimberti, Chiara Fenoglio, Marina Arcaro, Giancarlo Goi, Alessandra Barassi and Massimiliano Marco Corsi Romanelli

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1^−/Δ7 mice

The use of Akkermansia muciniphila as potential therapeutic intervention is receiving increasing attention. Health benefits attributed to this bacterium include an improvement of metabolic disorders and exerting ...

Authors: Benthe van der Lugt, Adriaan A. van Beek, Steven Aalvink, Ben Meijer, Bruno Sovran, Wilbert P. Vermeij, Renata M. C. Brandt, Willem M. de Vos, Huub F. J. Savelkoul, Wilma T. Steegenga and Clara Belzer

Taste receptors, innate immunity and longevity: the case of TAS2R16 gene

Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component o...

Authors: Alberto Malovini, Giulia Accardi, Anna Aiello, Riccardo Bellazzi, Giuseppina Candore, Calogero Caruso, Mattia Emanuela Ligotti, Anna Maciag, Francesco Villa and Annibale A. Puca

PTX3: an inflammatory protein modulating ultrastructure and bioenergetics of human endothelial cells

Pentraxin 3 (PTX3), an acute-phase inflammation protein produced by several cell types, has long been described as a possible biomarker for age-related cardiovascular and cerebrovascular diseases. Although sev...

Authors: Albino Carrizzo, Claudio Procaccini, Paola Lenzi, Clorinda Fusco, Francesco Villa, Serena Migliarino, Massimiliano De Lucia, Francesco Fornai, Giuseppe Matarese, Annibale A. Puca and Carmine Vecchione

Classical monocytes maintain ex vivo glycolytic metabolism and early but not later inflammatory responses in older adults

Inflammaging is a condition of chronic low-grade inflammation due to the aging process and is associated with a variety of chronic diseases. Monocytes are innate immune cells which contribute to inflammation a...

Authors: Brandt D. Pence and Johnathan R. Yarbro

Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Aβ accumulation

Apolipoprotein E4 (APOE4) and ageing are the most important known risk factors for late-onset Alzheimer’s disease (AD). In the present study, we determined the alterations of IgG, CD19, and Aβ in various brain...

Authors: Lihang Zhang, Juan Xu, Jinchao Gao, Peiqing Chen, Ming Yin and Wenjuan Zhao

Healthy lifestyles reduce suPAR and mortality in a Danish general population study

The plasma level of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is a strong predictor of disease development and premature mortality in the general population. Unhealthy...

Authors: Thomas Huneck Haupt, Line Jee Hartmann Rasmussen, Thomas Kallemose, Steen Ladelund, Ove Andersen, Charlotta Pisinger and Jesper Eugen-Olsen

Application of biological age assessment of Chinese population in potential anti-ageing technology

This study aimed to construct a biological age assessment formula for the Chinese population and to explore the effectiveness of double filtration plasmapheresis for anti-ageing and longevity.

Authors: Xufeng Li, Jiren Zhang, Chen Sun, Yuanyuan Zhang, Rui Cai, Shilin Fu, Jingfen Zheng and Dehai Huang

Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota

The influence of age on basophils is poorly understood, as well as the effect of aging-associated microbiota on basophils. Therefore, we studied the influence of aging and aging-associated microbiota on basoph...

Authors: Adriaan A. van Beek, Floris Fransen, Ben Meijer, Paul de Vos, Edward F. Knol and Huub F. J. Savelkoul

CD56bright cells respond to stimulation until very advanced age revealing increased expression of cellular protective proteins SIRT1, HSP70 and SOD2

NK cells are cytotoxic lymphocytes of innate immunity composed of: cytotoxic CD56dim and immunoregulatory CD56bright cells. The study aimed to analyze the expression of cellular protective proteins: sirtuin 1 ...

Authors: Lucyna Kaszubowska, Jerzy Foerster, Daria Schetz and Zbigniew Kmieć

Different age-independent effects of nutraceutical combinations on endothelium-mediated coronary flow reserve

Some components of Nutraceuticals (NUT) such as red yeast rice and Morus alba have demonstrated positive effects on the endothelial function in hypercholesterolemic subjects. Our aim was to compare the effects of...

Authors: Roberta Esposito, Regina Sorrentino, Giuseppe Giugliano, Marisa Avvedimento, Roberta Paolillo, Ciro Santoro, Maria Scalamogna, Mafalda Esposito, Federica Ilardi, Francesco Rozza, Giovanni Esposito, Maurizio Galderisi and Valentina Trimarco

Effects of chocolate containing Leuconostoc mesenteroides strain NTM048 on immune function: a randomized, double-blind, placebo-controlled trial

Previous reports showed that oral administration of Leuconostoc mesenteroides strain NTM048 increases IgA levels and CD4+ T cell population in feces and mice, respectively, as revealed by flow cytometric analysis...

Authors: Reiko Kuroda, Hiroaki Higuchi, Keishirou Yoshida, Yasunori Yonejima, Keiko Hisa, Masanori Utsuyama, Kenji Osawa and Katsuiku Hirokawa

Healthy elderly Singaporeans show no age-related humoral hyporesponsiveness nor diminished plasmablast generation in response to influenza vaccine

Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influe...

Authors: Xavier Camous, Lucian Visan, Crystal Tan Tze Ying, Brian Abel, Ma Shwe Zin Nyunt, Vipin Narang, Michael Poidinger, Christophe Carre, Sanie Sesay, Nabil Bosco, Nicolas Burdin, Paul Anantharajah Tambyah, Ng Tze Pin and Anis Larbi

A comprehensive characterization of aggravated aging-related changes in T lymphocytes and monocytes in end-stage renal disease: the iESRD study

Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown.

Authors: Yen-Ling Chiu, Kai-Hsiang Shu, Feng-Jung Yang, Tzu-Ying Chou, Ping-Min Chen, Fang-Yun Lay, Szu-Yu Pan, Cheng-Jui Lin, Nicolle H R Litjens, Michiel G H Betjes, Selma Bermudez, Kung-Chi Kao, Jean-San Chia, George Wang, Yu-Sen Peng and Yi-Fang Chuang

Association of immunoglobulin GM allotypes with longevity in long-living individuals from Southern Italy

The aim of this study was to analyse the role of GM allotypes, i.e. the hereditary antigenic determinants expressed on immunoglobulin polypeptide chains, in the attainment of longevity. The role played by immu...

Authors: Annibale A. Puca, Anna Ferrario, Anna Maciag, Giulia Accardi, Anna Aiello, Caterina Maria Gambino, Giuseppina Candore, Calogero Caruso, Aryan M. Namboodiri and Janardan P. Pandey

Genetics of exceptional longevity: possible role of GM allotypes

Authors: Calogero Caruso, Janardan P. Pandey and Annibale A. Puca

Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice

Crocetin, an agent derived from saffron, has multiple pharmacological properties, such as neuroprotective, anti-oxidant, and anti-inflammatory actions. These properties might benefit the treatment of Alzheimer...

Authors: Jin Zhang, Yuchao Wang, Xueshuang Dong and Jianghua Liu

Expression changes of autophagy-related proteins in AKI patients treated with CRRT and their effects on prognosis of adult and elderly patients

Sepsis is one of the common death factors in intensive care unit, which refers to the systemic inflammatory response syndrome caused by infection. It has many complications such as acute renal injury, shock, m...

Authors: Yang Zhang, Ling Wang, Lei Meng, Guang-Ke Cao, Yu-Liang Zhao and Yu Wu

Immunosenescence and lymphomagenesis

One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune syste...

Authors: Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso and Sergio Siragusa

The baseline levels and risk factors for high-sensitive C-reactive protein in Chinese healthy population

Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CR...

Authors: Ying Tang, Peifen Liang, Junzhe Chen, Sha Fu, Bo Liu, Min Feng, Baojuan Lin, Ben Lee, Anping Xu and Hui Y. Lan

Age does not influence the disease course in a mouse model of Streptococcus pneumoniae serotype 3 meningitis

In order to elucidate the causes for the increased mortality of aged patients with bacterial central nervous system (CNS) infections, we compared the course of Streptococcus pneumoniae (S. pneumoniae) meningitis ...

Authors: Anja Manig, Sandra Ribes, Catharina Diesselberg, Stephanie Bunkowski, Roland Nau and Sandra Schütze

Immune response to influenza vaccination in the elderly is altered by chronic medication use

The elderly patient population is the most susceptible to influenza virus infection and its associated complications. Polypharmacy is common in the aged, who often have multiple co-morbidities. Previous studie...

Authors: Divyansh Agarwal, Kenneth E. Schmader, Andrew V. Kossenkov, Susan Doyle, Raj Kurupati and Hildegund C. J. Ertl