Articles

A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age

There are currently > 600 million people over the age of 65 globally and this number is expected to double by the year 2050. Alcohol use among this population is on the rise, which is concerning as aging is as...

Authors: Rachel H McMahan, Kevin M Najarro, Juliet E Mullen, Madison T Paul, David J Orlicky, Holly J Hulsebus and Elizabeth J Kovacs

Validation of the effectiveness of SARS-CoV-2 vaccines in older adults in “real-world” settings

The rapidity of SARS-CoV-2 vaccination around the world has substantially reduced the number of new cases of COVID-19 and their severity in highly vaccinated countries. The unanticipated efficacy of SARS-CoV-2...

Authors: Nan-ping Weng and Graham Pawelec

Metabolic phenotype of B cells from young and elderly HIV individuals

HIV infection induces inflammaging and chronic immune activation (IA), which are negatively associated with protective humoral immunity. Similar to HIV, aging is also associated with increased inflammaging and...

Authors: Daniela Frasca, Suresh Pallikkuth and Savita Pahwa

Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people

Several SARS-CoV-2 vaccines have shown clinical efficacy against Covid-19 infection but there remains uncertainty about the immune responses elicited by different regimens. This is a particularly important que...

Authors: Helen Parry, Rachel Bruton, Christine Stephens, Kevin Brown, Gayatri Amirthalingam, Ashley Otter, Bassam Hallis, Jianmin Zuo and Paul Moss

May critical molecular cross-talk between indoleamine 2,3-dioxygenase (IDO) and arginase during human aging be targets for immunosenescence control?

This study aimed to identify novel plasma metabolic signatures with possible clinical relevance during the aging process. A biochemical quantitative phenotyping platform, based on targeted electrospray ionizat...

Authors: Ismael Dale Cotrim Guerreiro da Silva, Dirce Maria Lobo Marchioni, Antonio Augusto Ferreira Carioca, Valquiria Bueno and Gisele Wally Braga Colleoni

Correction to: Classical and lectin complement pathways and markers of inflammation for investigation of susceptibility to infections among healthy older adults

Authors: David C. LaFon, Steffen Thiel, Young-il Kim, Mark T. Dransfield and Moon H. Nahm

Does immunosenescence drive organismal ageing via inflammageing?

Authors: Graham Pawelec

A description of the relationship in healthy longevity and aging-related disease: from gene to protein

Human longevity is a complex phenotype influenced by both genetic and environmental factors. It is also known to be associated with various types of age-related diseases, such as Alzheimer’s disease (AD) and c...

Authors: Xiaolin Ni, Zhaoping Wang, Danni Gao, Huiping Yuan, Liang Sun, Xiaoquan Zhu, Qi Zhou and Ze Yang

Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related...

Authors: Usma Munawara, Michael Catanzaro, Weili Xu, Crystal Tan, Katsuiku Hirokawa, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque, Charles Ramassamy, Annelise E. Barron, Stephen Cunnane, Pascale B. Beauregard, Jean-Pierre Bellenger, Serafim Rodrigues…

miR-181a-regulated pathways in T-cell differentiation and aging

MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells,...

Authors: Chulwoo Kim, Zhongde Ye, Cornelia M. Weyand and Jörg J. Goronzy

Systemic transplantation of adult multipotent stem cells prevents articular cartilage degeneration in a mouse model of accelerated ageing

Osteoarthritis (OA) is one of the most prevalent joint diseases of advanced age and is a leading cause of disability worldwide. Ageing is a major risk factor for the articular cartilage (AC) degeneration that ...

Authors: Seth D. Thompson, Rajeswari Pichika, Richard L. Lieber and Mitra Lavasani

Is mechanical loading essential for exercise to preserve the aging immune system?

Authors: Richard J. Simpson and Graham Pawelec

A potential association between immunosenescence and high COVID-19 related mortality among elderly patients with cardiovascular diseases

Elderly patients with cardiovascular diseases account for a large proportion of Corona virus Disease 2019(COVID-19)related deaths. COVID-19, as a new coronavirus, mainly targets the patient’s lung triggering a...

Authors: Yuanyuan Wang, Shu-Chao Pang and Ying Yang

The age again in the eye of the COVID-19 storm: evidence-based decision making

One hundred fifty million contagions, more than 3 million deaths and little more than 1 year of COVID-19 have changed our lives and our health management systems forever. Ageing is known to be one of the signi...

Authors: María C. Martín, Aurora Jurado, Cristina Abad-Molina, Antonio Orduña, Oscar Yarce, Ana M. Navas, Vanesa Cunill, Danilo Escobar, Francisco Boix, Sergio Burillo-Sanz, María C. Vegas-Sánchez, Yesenia Jiménez-de las Pozas, Josefa Melero, Marta Aguilar, Oana Irina Sobieschi, Marcos López-Hoyos…

Functional conservation in genes and pathways linking ageing and immunity

At first glance, longevity and immunity appear to be different traits that have not much in common except the fact that the immune system promotes survival upon pathogenic infection. Substantial evidence howev...

Authors: Daniel K. Fabian, Matías Fuentealba, Handan Melike Dönertaş, Linda Partridge and Janet M. Thornton

Correction to: High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

An amendment to this paper has been published and can be accessed via the original article.

Authors: Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch and Andreas Thiel

CMV infection, CD19⁺ B cell depletion, and Lymphopenia as predictors for unexpected admission in the institutionalized elderly

Chronic infections played a detrimental role on health outcomes in the aged population, and had complex associations with lymphocyte subsets distribution. Our study aimed to explore the predictive roles of chr...

Authors: Liang-Yu Chen, An-Chun Hwang, Chung-Yu Huang, Liang-Kung Chen, Fu-Der Wang and Yu-Jiun Chan

High-dimensional single cell mass cytometry analysis of the murine hematopoietic system reveals signatures induced by ageing and physiological pathogen challenges

Immune ageing is a result of repetitive microbial challenges along with cell intrinsic or systemic changes occurring during ageing. Mice under ‘specific-pathogen-free’ (SPF) conditions are frequently used to a...

Authors: Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch and Andreas Thiel

Age-dependency of terminal ileum tissue resident memory T cell responsiveness profiles to S. Typhi following oral Ty21a immunization in humans

The impact of aging on the immune system is unequivocal and results in an altered immune status termed immunosenescence. In humans, the mechanisms of immunosenescence have been examined almost exclusively in b...

Authors: Jayaum S. Booth, Eric Goldberg, Seema A. Patil, Robin S. Barnes, Bruce D. Greenwald and Marcelo B. Sztein

An evaluation of the recognised systemic inflammatory biomarkers of chronic sub-optimal inflammation provides evidence for inflammageing (IFA) during multiple sclerosis (MS)

The pathogenesis of the human demyelinating disorder multiple sclerosis (MS) involves the loss of immune tolerance to self-neuroantigens. A deterioration in immune tolerance is linked to inherent immune ageing...

Authors: Christopher Bolton

Analysis of the heterogeneity of the BCR H-CDR3 repertoire in the bone marrow and spleen of 3-, 12-, and 20-month old mice

The number of central and peripheral B cells and their responsiveness are decreased in aged mice. The diversity of mice central and peripheral B cell repertoires with increasing age has not been elucidated. In...

Authors: Lina Ma, Xinxin Tao, Xiaoyan He, Peng Wang, Long Ma, Bin Shi and Xinsheng Yao

Local immune responses to tuberculin skin challenge in Mycobacterium bovis BCG-vaccinated baboons: a pilot study of younger and older animals

Individuals over the age of 65 are highly susceptible to infectious diseases, which account for one-third of deaths in this age group. Vaccines are a primary tool to combat infection, yet they are less effecti...

Authors: Julia M. Scordo, Tucker J. Piergallini, Nicole Reuter, Colwyn A. Headley, Vida L. Hodara, Olga Gonzalez, Luis D. Giavedoni, James F. Papin and Joanne Turner

Hypothetical COVID-19 protection mechanism: hints from centenarians

The risk of serious complications and the fatality rate due to COVID-19 pandemic have proven particularly higher in older persons, putting a further strain in healthcare system as we dramatically observed.

Authors: Franca Rosa Guerini, Matteo Cesari and Beatrice Arosio

Human endogenous retroviruses and ageing

Authors: Mikko Hurme and Graham Pawelec

Improving seasonal influenza vaccination for older adults

Authors: Graham Pawelec and Janet McElhaney

Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?

The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, an...

Authors: Cecilia Söderberg-Nauclér

Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children

Age-related changes in adaptive and innate immune cells have been associated with a decline in effective immunity and chronic, low-grade inflammation. Epigenetic, transcriptional, and functional changes in mon...

Authors: Katherine R. Dobbs, Paula Embury, Emmily Koech, Sidney Ogolla, Stephen Munga, James W. Kazura and Arlene E. Dent

Aging in psoriasis vulgaris: female patients are epigenetically older than healthy controls

Psoriasis vulgaris is a skin autoimmune disease. Psoriatic patients have significantly lowered life expectancy and suffer from various comorbidities. The main goal of the study was to determine whether psoriat...

Authors: Pavel Borsky, Marcela Chmelarova, Zdenek Fiala, Kvetoslava Hamakova, Vladimir Palicka, Jan Krejsek, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Martin Beranek, Andrea Malkova, Tereza Svadlakova, Drahomira Holmannova and Lenka Borska

Hyper‐metabolic B cells in the spleens of old mice make antibodies with autoimmune specificities

Aging is associated with increased intrinsic B cell inflammation, decreased protective antibody responses and increased autoimmune antibody responses. The effects of aging on the metabolic phenotype of B cells...

Authors: Daniela Frasca, Maria Romero, Denisse Garcia, Alain Diaz and Bonnie B. Blomberg

T cells accumulate in non-diabetic islets during ageing

The resident immune population of pancreatic islets has roles in islet development, beta cell physiology, and the pathology of diabetes. These roles have largely been attributed to islet macrophages, comprisin...

Authors: Heather C. Denroche, Stéphanie Miard, Sandrine Sallé-Lefort, Frédéric Picard and C. Bruce Verchere

Unanticipated efficacy of SARS-CoV-2 vaccination in older adults

The rapidity with which vaccines against COVID-19 have been developed and tested is unprecedented. As classically the case with randomized clinical trials, many studies excluded older adults. However, given th...

Authors: Graham Pawelec and Janet McElhaney

Reduced immune-regulatory molecule expression on human colonic memory CD4 T cells in older adults

The etiology of the low-level chronic inflammatory state associated with aging is likely multifactorial, but a number of animal and human studies have implicated a functional decline of the gastrointestinal im...

Authors: Stephanie M. Dillon, Tezha A. Thompson, Allison J. Christians, Martin D. McCarter and Cara C. Wilson

Aging and CMV discordance are associated with increased immune diversity between monozygotic twins

Broadly, much of variance in immune system phenotype has been linked to the influence of non-heritable factors rather than genetics. In particular, two non-heritable factors: aging and human cytolomegavirus (C...

Authors: Zheng Yan, Holden T. Maecker, Petter Brodin, Unni C. Nygaard, Shu Chen Lyu, Mark M. Davis, Kari C. Nadeau and Sandra Andorf

Macrophage function in the elderly and impact on injury repair and cancer

Older age is associated with deteriorating health, including escalating risk of diseases such as cancer, and a diminished ability to repair following injury. This rise in age-related diseases/co-morbidities is...

Authors: L Duong, HG Radley, B Lee, DE Dye, FJ Pixley, MD Grounds, DJ Nelson and C Jackaman

Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice

Physiological homeostasis decline, immunosenescence, and increased risk for multiple diseases, including neurodegeneration, are all hallmarks of ageing. Importantly, it is known that the ageing process is sex-...

Authors: Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, Janna Jernigan, Nikolay M. Filipov, Jessica M. Carpenter and Jae-Kyung Lee

Gut microbiota as the key controllers of “healthy” aging of elderly people

Extrinsic factors, such as lifestyle and diet, are shown to be essential in the control of human healthy aging, and thus, longevity. They do so by targeting at least in part the gut microbiome, a collection of...

Authors: Emeline Ragonnaud and Arya Biragyn

Obesity and COVID-19: what makes obese host so vulnerable?

The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symp...

Authors: Sameer Mohammad, Rafia Aziz, Saeed Al Mahri, Shuja Shafi Malik, Esraa Haji, Altaf Husain Khan, Tanvir Saleem Khatlani and Abderrezak Bouchama

T cell phenotypes associated with insulin resistance: results from the Berlin Aging Study II

Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiolog...

Authors: Julia Sbierski-Kind, David Goldeck, Nikolaus Buchmann, Joachim Spranger, Hans-Dieter Volk, Elisabeth Steinhagen-Thiessen, Graham Pawelec, Ilja Demuth and Dominik Spira

Correction to: Human MDSCs derived from the bone marrow maintain their functional ability but have a reduced frequency of induction in the elderly compared to pediatric donors

An amendment to this paper has been published and can be accessed via the original article.

Authors: Sara Magri, Elena Masetto, Samantha Solito, Samuela Francescato, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri and Susanna Mandruzzato

Autoimmune hemolytic anemia: current knowledge and perspectives

Autoimmune hemolytic anemia (AIHA) is an acquired, heterogeneous group of diseases which includes warm AIHA, cold agglutinin disease (CAD), mixed AIHA, paroxysmal cold hemoglobinuria and atypical AIHA. Current...

Authors: Sylwia Sulimiera Michalak, Anna Olewicz-Gawlik, Joanna Rupa-Matysek, Edyta Wolny-Rokicka, Elżbieta Nowakowska and Lidia Gil

Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination

Aging is characterized by a progressive decline in the capacity of the immune system to fight influenza virus infection and to respond to vaccination. Among the several factors involved, in addition to increas...

Authors: Daniela Frasca and Bonnie B. Blomberg

Pathogen burden and leukocyte telomere length in the United States

Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. We estimate...

Authors: Grace A. Noppert, Lydia Feinstein, Jennifer B. Dowd, Rebecca C. Stebbins, Emma Zang, Belinda L. Needham, Helen C. S. Meier, Amanda Simanek and Allison E. Aiello

Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis

Previously, we and others have reported higher populations of circulating neutrophils in patients with neovascular age-related macular degeneration (nAMD). Neutrophil gelatinase-associated lipocalin (NGAL, als...

Authors: Mei Chen, Nan Yang, Judith Lechner, Levente Toth, Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy and Heping Xu

An anti-CD6 monoclonal antibody (itolizumab) reduces circulating IL-6 in severe COVID-19 elderly patients

Since the COVID-19 outbreak an unprecedented challenge for healthcare systems around the world has been placed. In Cuba, the first case of COVID-19 was reported on March 11. Elderly with multiple comorbidities...

Authors: Danay Saavedra, Ana Laura Añé-Kourí, Naivy Sánchez, Lázaro Manuel Filgueira, Julio Betancourt, Carlos Herrera, Leniel Manso, Elibet Chávez, Armando Caballero, Carlos Hidalgo, Geydi Lorenzo, Meylan Cepeda, Carmen Valenzuela, Mayra Ramos, Kalet León, Zaima Mazorra…

SARS-CoV-2 and mitochondrial health: implications of lifestyle and ageing

Infection with SARs-COV-2 displays increasing fatality with age and underlying co-morbidity, in particular, with markers of the metabolic syndrome and diabetes, which seems to be associated with a “cytokine st...

Authors: Alistair V. W. Nunn, Geoffrey W. Guy, Wolfgang Brysch, Stanley W. Botchway, Wayne Frasch, Edward J. Calabrese and Jimmy D. Bell

Effect of age and sex on immune checkpoint expression and kinetics in human T cells

Immune checkpoints are crucial molecules in maintaining a proper immune balance. Even though age and sex are known to have effects on the immune system, the interplay between age, sex and immune checkpoint exp...

Authors: Rosanne D. Reitsema, Rebeca Hid Cadena, Sander H. Nijhof, Wayel H. Abdulahad, Minke G. Huitema, Davy Paap, Elisabeth Brouwer, Annemieke M. H. Boots and Peter Heeringa

Emergence of T cell immunosenescence in diabetic chronic kidney disease

Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced...

Authors: Yen-Ling Chiu, Wan-Chuan Tsai, Ruo-Wei Hung, I-Yu Chen, Kai-Hsiang Shu, Szu-Yu Pan, Feng-Jung Yang, Te-Tien Ting, Ju-Ying Jiang, Yu-Sen Peng and Yi-Fang Chuang

The correlation between the Th17/Treg cell balance and bone health

With the ageing of the world population, osteoporosis has become a problem affecting quality of life. According to the traditional view, the causes of osteoporosis mainly include endocrine disorders, metabolic...

Authors: Lei Zhu, Fei Hua, Wenge Ding, Kai Ding, Yige Zhang and Chenyang Xu

Reproducibility of serum cytokines in an elderly population

It is important to assess the temporal reproducibility of circulating cytokines for their utility in epidemiological studies. However, existing evidence is limited and inconsistent, especially for the elderly ...

Authors: Jing Guo, Nicole Schupf, Richard P. Mayeux and Yian Gu

Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

The immune system undergoes a myriad of changes with age. While it is known that antibody-secreting plasma and long-lived memory B cells change with age, it remains unclear how the binding profile of the circu...

Authors: Aaron Arvey, Michael Rowe, Joseph Barten Legutki, Gang An, Anantha Gollapudi, Anna Lei, Bill Colston, Chaim Putterman, David Smith, Janelle Stiles, Theodore Tarasow and Preveen Ramamoorthy