Articles

Virtual memory cells make a major contribution to the response of aged influenza-naïve mice to influenza virus infection

A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of perip...

Authors: Kathleen G. Lanzer, Tres Cookenham, William W. Reiley and Marcia A. Blackman

ESRD-associated immune phenotype depends on dialysis modality and iron status: clinical implications

End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect the T cell system.

Authors: Didier Ducloux, Mathieu Legendre, Jamal Bamoulid, Jean-Michel Rebibou, Philippe Saas, Cécile Courivaud and Thomas Crepin

Anti-cytomegalovirus IgG antibody titer is positively associated with advanced T cell differentiation and coronary artery disease in end-stage renal disease

Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individual...

Authors: Feng-Jung Yang, Kai-Hsiang Shu, Hung-Yuan Chen, I-Yu Chen, Fang-Yun Lay, Yi-Fang Chuang, Chien-Sheng Wu, Wan-Chuan Tsai, Yu-Sen Peng, Shih-Ping Hsu, Chih-Kang Chiang, George Wang and Yen-Ling Chiu

A study on the relationship between waist phenotype, hypertriglyceridemia, coronary artery lesions and serum free fatty acids in adult and elderly patients with coronary diseases

Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD.

Authors: Rui-Feng Yang, Hanlei Zhang, Zhongchun Wang, Xiao-Yong Liu and Zhi Lin

Thymus and activation-regulated chemokine (TARC)/CCL17 and IgE are associated with elderly asthmatics

The pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE, and infl...

Authors: Kyung Mi Jo, Hyo Kyung Lim, Jae Woong Sull, Eugene Choi, Ji-Sook Lee, Mee Ae Cheong, Min Hwa Hong, Yoori Kim and In Sik Kim

NK cells of the oldest seniors represent constant and resistant to stimulation high expression of cellular protective proteins SIRT1 and HSP70

Natural killer cells (NK cells) are cytotoxic lymphocytes of innate immunity that reveal some immunoregulatory properties, however, their role in the process of ageing is not completely understood. The study a...

Authors: Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda and Zbigniew Kmieć

Immune-inflammatory responses in the elderly: an update

Authors: Giulia Accardi and Calogero Caruso

Antibodies against 1940s era a/H1N1 influenza strains a/Weiss/43 and a/FM/1/47 and heterotypic responses after seasonal vaccination of an elderly Spanish population

Elderly people have experienced several influenza natural infections and seasonal vaccinations during their lives. The aim of this work was to evaluate in an elderly Spanish population the presence of antibodi...

Authors: Ivan Sanz, Silvia Rojo, Sonia Tamames, Jose María Eiros and Raúl Ortiz de Lejarazu

Gene and protein expression of CXCR4 in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations

Chronic rhinitis, pharyngitis and sinusitis are common health problems with a significant impact on public health, and are suspected to be influenced by ageing factors. Nasal inhalation with thermal water may ...

Authors: Monica Neri, Luigi Sansone, Luisa Pietrasanta, Aliaksei Kisialiou, Eloisa Cabano, Marina Martini, Matteo A. Russo, Donatella Ugolini, Marco Tafani and Stefano Bonassi

Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms

Human life develops and expands not only in time and space, but also in the retrograde permanent recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access...

Authors: Angela Trovato Salinaro, Manuela Pennisi, Rosanna Di Paola, Maria Scuto, Rosalia Crupi, Maria Teresa Cambria, Maria Laura Ontario, Mario Tomasello, Maurizio Uva, Luigi Maiolino, Edward J. Calabrese, Salvatore Cuzzocrea and Vittorio Calabrese

Effects of a new nutraceutical combination on cognitive function in hypertensive patients

Chronic increased arterial blood pressure has been associated with executive dysfunction, slowing of attention and mental processing speed, and later with memory deficits. Due to the absence of a concrete ther...

Authors: Giuseppe Giugliano, Alessia Salemme, Sara De Longis, Marialuisa Perrotta, Valentina D’Angelosante, Alessandro Landolfi, Raffaele Izzo and Valentina Trimarco

Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice

A possible relationship between periodontitis and Alzheimer’s disease (AD) has been reported. However, there is limited information on the association between the Porphyromonas gingivalis (P. gingivalis) periodon...

Authors: Ye Ding, Jingyi Ren, Hongqiang Yu, Weixian Yu and Yanmin Zhou

Interventions to restore appropriate immune function in the elderly

Advanced age is one indicator of likely immune dysfunction. As worldwide, the global population contains progressively more and more older individuals there is likelihood of an increased prevalence and inciden...

Authors: Richard Aspinall and Pierre Olivier Lang

Vaccines for the elderly: current use and future challenges

Age-related changes of the immune system contribute to increased incidence and severity of infections in the elderly. Vaccination is the most effective measure to prevent infections and vaccination recommendat...

Authors: Birgit Weinberger

The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway

With ageing, long-standing inflammation can be destructive, contributing to development of several disorders, among these Alzheimer’s disease (AD). C-reactive protein (CRP) is a relatively stable peripheral in...

Authors: Jessica Mira Gabin, Ingvild Saltvedt, Kristian Tambs and Jostein Holmen

Ageing: from inflammation to cancer

Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hal...

Authors: Giulia C. Leonardi, Giulia Accardi, Roberto Monastero, Ferdinando Nicoletti and Massimo Libra

Molecular changes associated with increased TNF-α-induced apoptotis in naïve (T_N) and central memory (T_CM) CD8+ T cells in aged humans

Progressive T cell decline in aged humans is associated with a deficiency of naïve (T_N) and central memory (T_CM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in...

Authors: Sudhir Gupta, Houfen Su, Sudhanshu Agrawal and Sastry Gollapudi

Immunological and non-immunological mechanisms of allergic diseases in the elderly: biological and clinical characteristics

A better hygiene, a Westernized diet, air pollution, climate changes, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance,...

Authors: Gabriele Di Lorenzo, Danilo Di Bona, Federica Belluzzo and Luigi Macchia

Immunosenescence in persons with spinal cord injury in relation to urinary tract infections -a cross-sectional study-

Individuals with a spinal cord injury (SCI), despite specialized rehabilitation and good health care, have a reduced life expectancy. Infectious diseases, such as pneumonias, infected pressure sores and urinar...

Authors: David Pavlicek, Jörg Krebs, Simona Capossela, Alessandro Bertolo, Britta Engelhardt, Jürgen Pannek and Jivko Stoyanov

Chlorinative stress in age-related diseases: a literature review

Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative s...

Authors: Marco Casciaro, Eleonora Di Salvo, Elisabetta Pace, Elvira Ventura-Spagnolo, Michele Navarra and Sebastiano Gangemi

Prescription database analyses indicates that the asthma medicine montelukast might protect against dementia: a hypothesis to be verified

It has recently been shown that the leukotriene receptor antagonist montelukast rejuvenates aged brains in rats. The question is whether this commonly used, systemic, anti-asthmatic medicine has a similar effe...

Authors: Bjørn Grinde and Bo Engdahl

Ileal antimicrobial peptide expression is dysregulated in old age

In an effort to understand the mechanisms underlying the high prevalence of gastrointestinal tract disorders in old age, we investigated the expression of intestinal antimicrobial peptides in the terminal smal...

Authors: Sarah Tremblay, Nathalie Marie Louise Côté, Guillaume Grenier, Gabriella Duclos-Lasnier, Louis-Charles Fortier, Subburaj Ilangumaran and Alfredo Menendez

Altered activation state of circulating neutrophils in patients with neovascular age-related macular degeneration

Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhe...

Authors: Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi and Torben Lykke Sørensen

Influenza vaccine response in community-dwelling German prefrail and frail individuals

The age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest ...

Authors: Jürgen M. Bauer, Antonio De Castro, Nabil Bosco, Celine Romagny, Rebecca Diekmann, Jalil Benyacoub and Karine Vidal

Long-term maintenance of diphtheria-specific antibodies after booster vaccination is hampered by latent infection with Cytomegalovirus

Many currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed con...

Authors: Birgit Weinberger, Michael Keller and Beatrix Grubeck-Loebenstein

Transcriptomic profiles of aging in naïve and memory CD4⁺ cells from mice

CD4+ T cells can be broadly divided into naïve and memory subsets, each of which are differentially impaired by the aging process. It is unclear if and how these differences are reflected at the transcriptomic...

Authors: Jackson Taylor, Lindsay Reynolds, Li Hou, Kurt Lohman, Wei Cui, Stephen Kritchevsky, Charles McCall and Yongmei Liu

pERK-dependent defective TCR-mediated activation of CD4⁺ T cells in end-stage renal disease patients

Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (E...

Authors: Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan and Michiel G. H. Betjes

Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: a pilot observational study

Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone re...

Authors: Emanuela Galliera, Monica Gioia Marazzi, Carmine Gazzaruso, Pietro Gallotti, Adriana Coppola, Tiziana Montalcini, Arturo Pujia and Massimiliano M. Corsi Romanelli

Age dependent accumulation patterns of advanced glycation end product receptor (RAGE) ligands and binding intensities between RAGE and its ligands differ in the liver, kidney, and skeletal muscle

Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end produ...

Authors: Myeongjoo Son, Wook-Jin Chung, Seyeon Oh, Hyosang Ahn, Chang Hu Choi, Suntaek Hong, Kook Yang Park, Kuk Hui Son and Kyunghee Byun

Low expression of CD39 and CD73 genes in centenarians compared with octogenarians

Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on ...

Authors: Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral and Jesús Pintor

Herpes virus seroepidemiology in the adult Swedish population

Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex ...

Authors: Jan Olsson, Eloise Kok, Rolf Adolfsson, Hugo Lövheim and Fredrik Elgh

Transcriptomic evidence of a para-inflammatory state in the middle aged lumbar spinal cord

We have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (LSC) of middle-aged male rats compared to young adults suggesting a para-inflammatory state devel...

Authors: William Galbavy, Yong Lu, Martin Kaczocha, Michelino Puopolo, Lixin Liu and Mario J. Rebecchi

Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults

A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccin...

Authors: Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, D. Nigel Thomas, Eloi Kpamegan, Hanxin Lu, Gale Smith, Somia P. Hickman, Pedro Piedra and Gregory M. Glenn

The anti-ageing molecule sirt1 mediates beneficial effects of cardiac rehabilitation

An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodyna...

Authors: Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A. Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli and Valeria Conti

CXCL-16, IL-17, and bone morphogenetic protein 2 (BMP-2) are associated with overweight and obesity conditions in middle-aged and elderly women

The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears...

Authors: Silvana Mara Turbino Luz Ribeiro, Laís Roquete Lopes, Guilherme de Paula Costa, Vivian Paulino Figueiredo, Deena Shrestha, Aline Priscila Batista, Roney Luiz de Carvalho Nicolato, Fernando Luiz Pereira de Oliveira, Juliana Assis Silva Gomes and Andre Talvani

Changes in peripheral immune cell numbers and functions in octogenarian walkers – an acute exercise study

Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral ...

Authors: Kornelis S. M. van der Geest, Qi Wang, Thijs M. H. Eijsvogels, Hans J. P. Koenen, Irma Joosten, Elisabeth Brouwer, Maria T. E. Hopman, Joannes F. M. Jacobs and Annemieke M. H. Boots

Erratum to: Frailty has a stronger association with inflammation than age in older veterans

Authors: P. Van Epps, D. Oswald, P. A. Higgins, T. R. Hornick, H. Aung, R. E. Banks, B. M. Wilson, C. Burant, S. Gravenstein and D. H. Canaday

Expression of cellular protective proteins SIRT1, HSP70 and SOD2 correlates with age and is significantly higher in NK cells of the oldest seniors

NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression...

Authors: Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda and Zbigniew Kmieć

Lifewide profile of cytokine production by innate and adaptive immune cells from Brazilian individuals

Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytok...

Authors: Gabriela Silveira-Nunes, Elaine Speziali, Andréa Teixeira-Carvalho, Danielle M. Vitelli-Avelar, Renato Sathler-Avelar, Taciana Figueiredo-Soares, Maria Luiza Silva, Vanessa Peruhype-Magalhães, Daniel Gonçalves Chaves, Gustavo Eustáquio Brito-Melo, Glenda Meira Cardoso, Eric Bassetti Soares, Silvana Maria Elói-Santos, Rosângela Teixeira, Dulciene Magalhães Queiroz, Rodrigo Corrêa-Oliveira…

A pilot observational study on magnesium and calcium imbalance in elderly patients with acute aortic dissection

Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Conseq...

Authors: E. Vianello, E. Dozio, A. Barassi, G. Sammarco, L. Tacchini, M. M. Marrocco-Trischitta, S. Trimarchi and M. M. Corsi Romanelli

Frailty has a stronger association with inflammation than age in older veterans

Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the ...

Authors: P. Van Epps, D. Oswald, P. A. Higgins, T. R. Hornick, H. Aung, R. E. Banks, B. M. Wilson, C. Burant, S. Gravenstein and D. H. Canaday

Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults

We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals....

Authors: Marco Grasse, Andreas Meryk, Michael Schirmer, Beatrix Grubeck-Loebenstein and Birgit Weinberger

The inflammatory protein Pentraxin 3 in cardiovascular disease

The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate...

Authors: Francesco Fornai, Albino Carrizzo, Maurizio Forte, Mariateresa Ambrosio, Antonio Damato, Michela Ferrucci, Francesca Biagioni, Carla Busceti, Annibale A. Puca and Carmine Vecchione

Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors

Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stabl...

Authors: Yun Lin, Jiewan Kim, E. Jeffrey Metter, Huy Nguyen, Thai Truong, Ana Lustig, Luigi Ferrucci and Nan-ping Weng

Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer’s disease pathogenesis

There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have lon...

Authors: A. Trovato, R. Siracusa, R. Di Paola, M. Scuto, M. L. Ontario, Ornella Bua, Paola Di Mauro, M. A. Toscano, C. C. T. Petralia, L. Maiolino, A. Serra, S. Cuzzocrea and Vittorio Calabrese

Elastic band resistance training influences transforming growth factor-ß receptor I mRNA expression in peripheral mononuclear cells of institutionalised older adults: the Vienna Active Ageing Study (VAAS)

Ageing, inactivity and obesity are associated with chronic low-grade inflammation contributing to a variety of lifestyle-related diseases. Transforming growth factor-β (TGF-β) is a multimodal protein with vari...

Authors: Barbara Schober-Halper, Marlene Hofmann, Stefan Oesen, Bernhard Franzke, Thomas Wolf, Eva-Maria Strasser, Norbert Bachl, Michael Quittan, Karl-Heinz Wagner and Barbara Wessner

Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study

In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and ol...

Authors: Monika Puzianowska-Kuźnicka, Magdalena Owczarz, Katarzyna Wieczorowska-Tobis, Pawel Nadrowski, Jerzy Chudek, Przemyslaw Slusarczyk, Anna Skalska, Marta Jonas, Edward Franek and Malgorzata Mossakowska

The prognostic value of biomarkers in stroke

Ischemic injury triggers inflammatory cascades and changes in the protein synthesis, neurotransmitters and neuro-hormones in the brain parenchyma that may further amplify the tissue damage. The “Triage® Stroke...

Authors: Francesco Iemolo, Enzo Sanzaro, Giovanni Duro, Antonello Giordano and Maurizio Paciaroni

Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes

Over the past fifteen years, we have demonstrated that cortisol and dehydroepiandrosterone (DHEA) have opposite effects on the regulation of protein kinase C (PKC) activity in the context of the immune system....

Authors: Emanuela Corsini, Valentina Galbiati, Angela Papale, Elena Kummer, Antonella Pinto, Melania M. Serafini, Antonio Guaita, Roberto Spezzano, Donatella Caruso, Marina Marinovich and Marco Racchi

Nutrigerontology: a key for achieving successful ageing and longevity

During the last two centuries the average lifespan has increased at a rate of approximately 3 months/year in both sexes, hence oldest old people are becoming the population with the fastest growth in Western W...

Authors: Anna Aiello, Giulia Accardi, Giuseppina Candore, Giuseppe Carruba, Sergio Davinelli, Giuseppe Passarino, Giovanni Scapagnini, Sonya Vasto and Calogero Caruso