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Research
Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhe...
Immunity & Ageing 2017 14:18
Published on: 27 July 2017
Research
The age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest ...
Immunity & Ageing 2017 14:17
Published on: 6 July 2017
Short report
Many currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed con...
Immunity & Ageing 2017 14:16
Published on: 26 June 2017
Research
CD4+ T cells can be broadly divided into naïve and memory subsets, each of which are differentially impaired by the aging process. It is unclear if and how these differences are reflected at the transcriptomic...
Immunity & Ageing 2017 14:15
Published on: 20 June 2017
Research
Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (E...
Immunity & Ageing 2017 14:14
Published on: 19 June 2017
Research
Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone re...
Immunity & Ageing 2017 14:13
Published on: 14 June 2017
Research
Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end produ...
Immunity & Ageing 2017 14:12
Published on: 5 June 2017
Short report
Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on ...
Immunity & Ageing 2017 14:11
Published on: 19 May 2017
Research
Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex ...
Immunity & Ageing 2017 14:10
Published on: 10 May 2017
Research
We have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (LSC) of middle-aged male rats compared to young adults suggesting a para-inflammatory state devel...
Immunity & Ageing 2017 14:9
Published on: 13 April 2017
Research
A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccin...
Immunity & Ageing 2017 14:8
Published on: 12 April 2017
Research
An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodyna...
Immunity & Ageing 2017 14:7
Published on: 16 March 2017
Research
The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears...
Immunity & Ageing 2017 14:6
Published on: 11 March 2017
Research
Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral ...
Immunity & Ageing 2017 14:5
Published on: 22 February 2017
Erratum
Immunity & Ageing 2017 14:4
Published on: 16 February 2017
The original article was published in Immunity & Ageing 2016 13:27
Research
NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression...
Immunity & Ageing 2017 14:3
Published on: 23 January 2017
Research
Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytok...
Immunity & Ageing 2017 14:2
Published on: 23 January 2017
Research
Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Conseq...
Immunity & Ageing 2017 14:1
Published on: 5 January 2017
Research
Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the ...
Immunity & Ageing 2016 13:27
Published on: 19 October 2016
The Erratum to this article has been published in Immunity & Ageing 2017 14:4
Short report
We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals....
Immunity & Ageing 2016 13:26
Published on: 5 September 2016
Review
The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate...
Immunity & Ageing 2016 13:25
Published on: 24 August 2016
Research
Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stabl...
Immunity & Ageing 2016 13:24
Published on: 18 August 2016
Research
There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases. Mushrooms have lon...
Immunity & Ageing 2016 13:23
Published on: 9 July 2016
Research
Ageing, inactivity and obesity are associated with chronic low-grade inflammation contributing to a variety of lifestyle-related diseases. Transforming growth factor-β (TGF-β) is a multimodal protein with vari...
Immunity & Ageing 2016 13:22
Published on: 30 June 2016
Research
In the elderly, chronic low-grade inflammation (inflammaging) is a risk factor for the development of aging-related diseases and frailty. Using data from several thousand Eastern Europeans aged 65 years and ol...
Immunity & Ageing 2016 13:21
Published on: 3 June 2016
