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  1. Global life expectancy is rising, with the 60 + age group projected to hit 2 billion by 2050. Aging impacts the immune system. A notable marker of immune system aging is the presence of Aging-Related Immune Ce...

    Authors: Ahmed A. Y. Ragab, Margaret F. Doyle, Jiachen Chen, Yuan Fang, Kathryn L. Lunetta and Joanne M. Murabito
    Citation: Immunity & Ageing 2024 21:37
  2. The immune response changes during aging and the progression of Alzheimer’s disease (AD) and related dementia (ADRD). Terminally differentiated effector memory T cells (called TEMRA) are important during aging an...

    Authors: Edric Winford, Jenny Lutshumba, Barbara J. Martin, Donna M. Wilcock, Gregory A. Jicha, Barbara S. Nikolajczyk, Ann M. Stowe and Adam D. Bachstetter
    Citation: Immunity & Ageing 2024 21:36
  3. Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci requires robust pulmonary neutrophil influx early in infection. However, aging is associa...

    Authors: Shaunna R. Simmons, Sydney E. Herring, Essi Y.I Tchalla, Alexsandra P. Lenhard, Manmeet Bhalla and Elsa N. Bou Ghanem
    Citation: Immunity & Ageing 2024 21:34
  4. Research has suggested significant correlations among ageing, immune microenvironment, inflammation and tumours. However, the relationships among ageing, immune microenvironment, cystitis and bladder urothelia...

    Authors: Jiang Zhao, Xing Luo, Chengfei Yang, Xiao Yang, Min Deng, Bishao Sun, Jingzhen Zhu, Zongming Dong, Yangcai Wang, Jia Li, Xingliang Yang, Benyi Li, Xiangwei Wang and Ji Zheng
    Citation: Immunity & Ageing 2024 21:33
  5. An elevated neutrophil–lymphocyte ratio (NLR) in blood has been associated with Alzheimer’s disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD...

    Authors: Tovia Jacobs, Sean R. Jacobson, Juan Fortea, Jeffrey S. Berger, Alok Vedvyas, Karyn Marsh, Tianshe He, Eugenio Gutierrez-Jimenez, Nathanael R. Fillmore, Moses Gonzalez, Luisa Figueredo, Naomi L. Gaggi, Chelsea Reichert Plaska, Nunzio Pomara, Esther Blessing, Rebecca Betensky…
    Citation: Immunity & Ageing 2024 21:32
  6. The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. Irisin, a muscle-derived hormone produced by the proteolytic cleavage of Fibronectin-do...

    Authors: Cailin Wang, Xiufeng Wang, Shangqi Sun, Yanmin Chang, Piaopiao Lian, Hongxiu Guo, Siyi Zheng, Rong Ma and Gang Li
    Citation: Immunity & Ageing 2024 21:30
  7. Quercetin is a flavonol compound widely distributed in plants that possesses diverse biological properties, including antioxidative, anti-inflammatory, anticancer, neuroprotective and senescent cell-clearing a...

    Authors: Tingting Su, Haitao Shen, Mengyuan He, Shanshan Yang, Xue Gong, Ce Huang, Liuling Guo, Hao Wang, Shengyu Feng, Taotao Mi, Meili Zhao, Qing Liu, Fengjiao Huo, Jian-Kang Zhu, Jianbo Zhu, Hongbin Li…
    Citation: Immunity & Ageing 2024 21:29
  8. Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chroni...

    Authors: Johanne Poisson, Carine El-Sissy, Arnaud Serret-Larmande, Nikaïa Smith, Morgane Lebraud, Jean-Loup Augy, Catherine Conti, Cécile Gonnin, Benjamin Planquette, Jean-Benoît Arlet, Bertrand Hermann, Bruno Charbit, Jean Pastre, Floriane Devaux, Cyrielle Ladavière, Lydie Lim…
    Citation: Immunity & Ageing 2024 21:28
  9. Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized by lipid accumulation and immune cell responses in the vascular wall, resulting in plaq...

    Authors: Virginia Smit, Jill de Mol, Mireia N. A. Bernabé Kleijn, Marie A. C. Depuydt, Menno P. J. de Winther, Ilze Bot, Johan Kuiper and Amanda C. Foks
    Citation: Immunity & Ageing 2024 21:27
  10. Authors: Qinqin Pan, Xiao Ma, Yajie You, Yuejiao Yu, Su Fan, Xiaoyan Wang, Mengyuan Wang, Ming Gao, Guangming Gong, Kourong Miao, Jie Shen and Xiaoyu Zhou
    Citation: Immunity & Ageing 2024 21:25

    The original article was published in Immunity & Ageing 2024 21:15

  11. The tonsils operate as a protection ring of mucosa at the gates of the upper aero-digestive tract. They show similarities with lymph nodes and participate as inductive organs of systemic and mucosal immunity. ...

    Authors: Rocío Pastor, Juliana Puyssegur, M. Paula de la Guardia, Lindybeth Sarmiento Varón, Gladys Beccaglia, Nicolás Spada, Andrea Paes de Lima, M. Soledad Collado, Andrés Blanco, Isabel Aspe Scetti, M. Elena Arabolaza, Bibiana Paoli, Fernando Chirdo and Eloísa Arana
    Citation: Immunity & Ageing 2024 21:24
  12. It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk Factors, Aging and Dementia (CAIDE) model.

    Authors: Kira Trares, Manuel Wiesenfarth, Hannah Stocker, Laura Perna, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner and Ben Schöttker
    Citation: Immunity & Ageing 2024 21:23
  13. Human old aged unmutated chronic lymphocytic leukemia U-CLL are the TCL1+ZAP70+CD5+ B cells. Since CD5 makes the BCR signaling tolerance, ZAP70 increased in U-CLL not only TCL1+ alone. In mice, TCL1 (TCL1A) is th...

    Authors: Kyoko Hayakawa, Yan Zhou and Susan A. Shinton
    Citation: Immunity & Ageing 2024 21:22
  14. Advancing age is a major risk factor for respiratory viral infections. The infections are often prolonged and difficult to resolve resulting hospitalizations and mortality. The recent COVID-19 pandemic has hig...

    Authors: Sudhanshu Agrawal, Michelle Thu Tran, Tara Sinta Kartika Jennings, Marlaine Maged Hosny Soliman, Sally Heo, Bobby Sasson, Farah Rahmatpanah and Anshu Agrawal
    Citation: Immunity & Ageing 2024 21:21
  15. People living with HIV (PLWH) are at risk of frailty, which is predictive for death. As an overactivity of the immune system is thought to fuel frailty, we characterized the immune activation profiles linked t...

    Authors: Lucy Kundura, Renaud Cezar, Sandrine Gimenez, Manuela Pastore, Christelle Reynes, Albert Sotto, Jacques Reynes, Clotilde Allavena, Laurence Meyer, Alain Makinson and Pierre Corbeau
    Citation: Immunity & Ageing 2024 21:20
  16. Increased levels of pro-inflammatory proteins in plasma can be detected in older individuals and associate with the so called chronic low-grade inflammation, which contributes to a faster progression of aged-r...

    Authors: Monica Cattaneo, Andrea Baragetti, Alberto Malovini, Elena Ciaglia, Valentina Lopardo, Elena Olmastroni, Manuela Casula, Carolina Ciacci, Alberico L. Catapano and Annibale A. Puca
    Citation: Immunity & Ageing 2024 21:19
  17. Turquoise killifish (Nothobranchius furzeri) evolved a naturally short lifespan of about six months and exhibit aging hallmarks that affect multiple organs. These hallmarks include protein aggregation, telomere s...

    Authors: Gabriele Morabito, Alina Ryabova and Dario Riccardo Valenzano
    Citation: Immunity & Ageing 2024 21:18
  18. Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may compromise lung function through cell damage and par...

    Authors: Mailton Prestes Madruga, Lucas Kich Grun, Letícya Simone Melo Dos Santos, Frederico Orlando Friedrich, Douglas Bitencourt Antunes, Marcella Elesbão Fogaça Rocha, Pedro Luis Silva, Gilson P. Dorneles, Paula Coelho Teixeira, Tiago Franco Oliveira, Pedro R.T. Romão, Lucas Santos, José Claudio Fonseca Moreira, Vinicius Schenk Michaelsen, Marcelo Cypel, Marcos Otávio Brum Antunes…
    Citation: Immunity & Ageing 2024 21:17
  19. With the development of Hematopoietic Stem Cell Transplantation (HSCT) technology, increasing numbers of elderly patients were undergoing allogeneic HSCT and elderly patients with hematologic malignancies coul...

    Authors: Qinqin Pan, Xiao Ma, Yajie You, Yuejiao Yu, Su Fan, Xiaoyan Wang, Mengyuan Wang, Ming Gao, Guangming Gong, Kourong Miao, Jie Shen and Xiaoyu Zhou
    Citation: Immunity & Ageing 2024 21:15

    The Correction to this article has been published in Immunity & Ageing 2024 21:25

  20. The gradual aging of the global population has led to a surge in age-related diseases, which seriously threaten human health. Researchers are dedicated to understanding and coping with the complexities of agin...

    Authors: Ruikai Liang, Xinrui Qi, Qi Cai, Liyan Niu, Xi Huang, Deju Zhang, Jitao Ling, Yuting Wu, Yixuan Chen, Pingping Yang, Jianping Liu, Jing Zhang and Peng Yu
    Citation: Immunity & Ageing 2024 21:14
  21. Obesity, which is the accumulation of fat in adipose tissue, has adverse impacts on human health. Obesity-related metabolic dysregulation has similarities to the metabolic alterations observed in aging. It has...

    Authors: Ghazaleh Shimi, Mohammad Hassan Sohouli, Arman Ghorbani, Azam Shakery and Hamid Zand
    Citation: Immunity & Ageing 2024 21:13

    The Correction to this article has been published in Immunity & Ageing 2024 21:31

  22. In the context of the COVID-19 pandemic and extensive vaccination, it is important to explore the immune response of elderly adults to homologous and heterologous booster vaccines of COVID-19. At this point, w...

    Authors: Yuwei Zhang, Lianxiang Zhao, Jinzhong Zhang, Xiaomei Zhang, Shanshan Han, Qingshuai Sun, Mingxiao Yao, Bo Pang, Qing Duan and Xiaolin Jiang
    Citation: Immunity & Ageing 2024 21:11
  23. Age-related changes in the ovarian microenvironment are linked to impaired fertility in women. Macrophages play important roles in ovarian tissue homeostasis and immune surveillance. However, the impact of agi...

    Authors: Hui-Hui Shen, Xin-Yan Zhang, Nan Liu, Yang-Yang Zhang, Hui-Hua Wu, Feng Xie, Wen-Jun Wang and Ming-Qing Li
    Citation: Immunity & Ageing 2024 21:10
  24. Inflammaging, the characteristics of immunosenescence, characterized by continuous chronic inflammation that could not be resolved. It is not only affect older people but can also occur in young individuals, ...

    Authors: Andrea Aprilia, Kusworini Handono, Hidayat Sujuti, Akhmad Sabarudin and Nuning Winaris
    Citation: Immunity & Ageing 2024 21:9
  25. The Disposable Soma Theory of aging suggests a trade-off between energy allocation for growth, reproduction and somatic maintenance, including immunity. While trade-offs between reproduction and immunity are w...

    Authors: Agathe Crosland, Thierry Rigaud, Charlène Develay and Yannick Moret
    Citation: Immunity & Ageing 2024 21:7
  26. The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convale...

    Authors: Janet M. Lord, Tonny Veenith, Jack Sullivan, Archana Sharma-Oates, Alex G. Richter, Neil J. Greening, Hamish J. C. McAuley, Rachael A. Evans, Paul Moss, Shona C. Moore, Lance Turtle, Nandan Gautam, Ahmed Gilani, Manan Bajaj, Louise V. Wain, Christopher Brightling…
    Citation: Immunity & Ageing 2024 21:6
  27. Aging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of aging. The bone marrow is the most important hematopoietic immune organ, ...

    Authors: Jianjie Lv, Chun Zhang, Xiuxing Liu, Chenyang Gu, Yidan Liu, Yuehan Gao, Zhaohao Huang, Qi Jiang, Binyao Chen, Daquan He, Tianfu Wang, Zhuping Xu and Wenru Su
    Citation: Immunity & Ageing 2024 21:3
  28. Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive d...

    Authors: Cristina Rodriguez-Rodriguez, Natalia González-Mancha, Ane Ochoa-Echeverría, Rosa Liébana and Isabel Merida
    Citation: Immunity & Ageing 2024 21:2
  29. Parkinson’s disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the degeneration of dopamine (DA) neurons. The prevalence of PD has experienced a significant surg...

    Authors: Bang-rong Wei, Yu-jia Zhao, Yu-feng Cheng, Chun Huang and Feng Zhang
    Citation: Immunity & Ageing 2024 21:1
  30. Coronavirus disease COVID-19 is a heterogeneous condition caused by SARS-CoV-2 infection. Generally, it is characterized by interstitial pneumonia that can lead to impaired gas-exchange, acute respiratory fail...

    Authors: Robertina Giacconi, Patrizia D’Aquila, Maurizio Cardelli, Francesco Piacenza, Elisa Pierpaoli, Giada Sena, Mirko Di Rosa, Anna Rita Bonfigli, Roberta Galeazzi, Antonio Cherubini, Massimiliano Fedecostante, Riccardo Sarzani, Chiara Di Pentima, Piero Giordano, Roberto Antonicelli, Fabrizia Lattanzio…
    Citation: Immunity & Ageing 2023 20:76
  31. Although the concept of declined immune function associated with cancer has been accepted extensively, real-world clinical studies focusing on analysis of the peripheral blood immune changes underlying ageing,...

    Authors: Xiaomin Fu, Peng Qin, Fanghui Li, Huifang Zhu, Hongqin You, Yong Zhang, Benling Xu, Tiepeng Li, Fang Zhang, Lu Han, Lingdi Zhao, Baozhen Ma, Zibing Wang and Quanli Gao
    Citation: Immunity & Ageing 2023 20:75
  32. Alzheimer’s disease (AD), which is the most common cause of dementia in elderly individuals, is a progressive neurodegenerative disorder. Neuroinflammation, which is an immune response that is activated by gli...

    Authors: Min Cao, Jing Liu, Xiaomin Zhang, Yaqi Wang, Yuli Hou, Qiao Song, Yuting Cui, Yue Zhao and Peichang Wang
    Citation: Immunity & Ageing 2023 20:74
  33. Immunosenescence occurs as people age, leading to an increased incidence of age-related diseases. The number of senescent T cells also rises with age. T cell senescence and immune response dysfunction can resu...

    Authors: Jia Yang, Hai-Cheng Liu, Jian-Qing Zhang, Jian-Yong Zou, Xin Zhang, Wo-Ming Chen, Yong Gu and Hai Hong
    Citation: Immunity & Ageing 2023 20:73
  34. Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remains elusive. Consequently, therapeutic interventions for oral lichen planus are limited ...

    Authors: Shogo Ijima, Yuki Saito, Sena Yamamoto, Kentaro Nagaoka, Taiki Iwamoto, Arisa Kita, Maki Miyajima, Tsukasa Sato, Akihiro Miyazaki and Takako S. Chikenji
    Citation: Immunity & Ageing 2023 20:72
  35. Memory CD8+ T cells expand with age. We previously demonstrated an age-associated expansion of effector memory (EM) CD8+ T cells expressing low levels of IL-7 receptor alpha (IL-7Rαlow) and the presence of its ge...

    Authors: Juan Joseph Young, Hong-Jai Park, Minhyung Kim, Jennefer Par-Young, Hugh Bartlett, Hye Sun Kim, Serhan Unlu, Lais Osmani, Min Sun Shin, Richard Bucala, Christopher H. van Dyck, Heather Allore, Adam P. Mecca, Sungyong You and Insoo Kang
    Citation: Immunity & Ageing 2023 20:71
  36. Nicotinamide adenine dinucleotide (NAD+), a crucial coenzyme in cellular redox reactions, is closely associated with age-related functional degeneration and metabolic diseases. NAD exerts direct and indirect i...

    Authors: Jinghui Liang, Feiling Huang, Zhaoqi Song, Ruiyi Tang, Peng Zhang and Rong Chen
    Citation: Immunity & Ageing 2023 20:70
  37. Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF...

    Authors: Yannick van Sleen, Sudarshan A. Shetty, Marieke van der Heiden, Milou C. A. Venema, Nicolas Gutiérrez-Melo, Erik J. M. Toonen, Josine van Beek, Anne-Marie Buisman, Debbie van Baarle and Delphine Sauce
    Citation: Immunity & Ageing 2023 20:68
  38. TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands...

    Authors: Hyo-Jin Kim, Hyemin Kim, Jeong-Hyung Lee and Cheol Hwangbo
    Citation: Immunity & Ageing 2023 20:67
  39. CircZBTB46 has been identified as being associated with the risk of coronary artery disease (CAD) and has the potential to be a diagnostic biomarker for CAD. However, the specific function and detailed mechani...

    Authors: Yahong Fu, Qiaowei Jia, Mengmeng Ren, Hengjie Bie, Xin Zhang, Qian Zhang, Shu He, Chengcheng Li, Hanxiao Zhou, Yanjun Wang, Xiongkang Gan, Zhengxian Tao, Xiumei Chen and Enzhi Jia
    Citation: Immunity & Ageing 2023 20:66
  40. The spaceflight environment is an extreme environment that affects the immune system of approximately 50% of astronauts. With planned long-duration missions, such as the deployment of the Lunar Gateway and pos...

    Authors: Coralie Fonte, Pauline Jacob, Anne Vanet, Stéphanie Ghislin and Jean-Pol Frippiat
    Citation: Immunity & Ageing 2023 20:64

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