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  1. Content type: Research

    Sepsis is one of the common death factors in intensive care unit, which refers to the systemic inflammatory response syndrome caused by infection. It has many complications such as acute renal injury, shock, m...

    Authors: Yang Zhang, Ling Wang, Lei Meng, Guang-Ke Cao, Yu-Liang Zhao and Yu Wu

    Citation: Immunity & Ageing 2018 15:23

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  2. Content type: Review

    One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune syste...

    Authors: Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso and Sergio Siragusa

    Citation: Immunity & Ageing 2018 15:22

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  3. Content type: Research

    Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CR...

    Authors: Ying Tang, Peifen Liang, Junzhe Chen, Sha Fu, Bo Liu, Min Feng, Baojuan Lin, Ben Lee, Anping Xu and Hui Y. Lan

    Citation: Immunity & Ageing 2018 15:21

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  4. Content type: Short report

    In order to elucidate the causes for the increased mortality of aged patients with bacterial central nervous system (CNS) infections, we compared the course of Streptococcus pneumoniae (S. pneumoniae) meningitis ...

    Authors: Anja Manig, Sandra Ribes, Catharina Diesselberg, Stephanie Bunkowski, Roland Nau and Sandra Schütze

    Citation: Immunity & Ageing 2018 15:20

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  5. Content type: Research

    The elderly patient population is the most susceptible to influenza virus infection and its associated complications. Polypharmacy is common in the aged, who often have multiple co-morbidities. Previous studie...

    Authors: Divyansh Agarwal, Kenneth E. Schmader, Andrew V. Kossenkov, Susan Doyle, Raj Kurupati and Hildegund C. J. Ertl

    Citation: Immunity & Ageing 2018 15:19

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  6. Content type: Correction

    In the original publication of this article [1] there is an error in Fig. 3a as the labels “TM” and “VM” are in the wrong order for the last plot. The CD49d high cells should be “TM” and the CD49d low cells sh...

    Authors: Kathleen G. Lanzer, Tres Cookenham, William W. Reiley and Marcia A. Blackman

    Citation: Immunity & Ageing 2018 15:18

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    The original article was published in Immunity & Ageing 2018 15:17

  7. Content type: Research

    A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of perip...

    Authors: Kathleen G. Lanzer, Tres Cookenham, William W. Reiley and Marcia A. Blackman

    Citation: Immunity & Ageing 2018 15:17

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    The Correction to this article has been published in Immunity & Ageing 2018 15:18

  8. Content type: Research

    End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect the T cell system.

    Authors: Didier Ducloux, Mathieu Legendre, Jamal Bamoulid, Jean-Michel Rebibou, Philippe Saas, Cécile Courivaud and Thomas Crepin

    Citation: Immunity & Ageing 2018 15:16

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  9. Content type: Research

    Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individual...

    Authors: Feng-Jung Yang, Kai-Hsiang Shu, Hung-Yuan Chen, I-Yu Chen, Fang-Yun Lay, Yi-Fang Chuang, Chien-Sheng Wu, Wan-Chuan Tsai, Yu-Sen Peng, Shih-Ping Hsu, Chih-Kang Chiang, George Wang and Yen-Ling Chiu

    Citation: Immunity & Ageing 2018 15:15

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  10. Content type: Research

    Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD.

    Authors: Rui-Feng Yang, Hanlei Zhang, Zhongchun Wang, Xiao-Yong Liu and Zhi Lin

    Citation: Immunity & Ageing 2018 15:14

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  11. Content type: Research

    The pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE, and infl...

    Authors: Kyung Mi Jo, Hyo Kyung Lim, Jae Woong Sull, Eugene Choi, Ji-Sook Lee, Mee Ae Cheong, Min Hwa Hong, Yoori Kim and In Sik Kim

    Citation: Immunity & Ageing 2018 15:13

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  12. Content type: Research

    Natural killer cells (NK cells) are cytotoxic lymphocytes of innate immunity that reveal some immunoregulatory properties, however, their role in the process of ageing is not completely understood. The study a...

    Authors: Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda and Zbigniew Kmieć

    Citation: Immunity & Ageing 2018 15:12

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  13. Content type: Research

    Elderly people have experienced several influenza natural infections and seasonal vaccinations during their lives. The aim of this work was to evaluate in an elderly Spanish population the presence of antibodi...

    Authors: Ivan Sanz, Silvia Rojo, Sonia Tamames, Jose María Eiros and Raúl Ortiz de Lejarazu

    Citation: Immunity & Ageing 2018 15:9

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  14. Content type: Research

    Chronic rhinitis, pharyngitis and sinusitis are common health problems with a significant impact on public health, and are suspected to be influenced by ageing factors. Nasal inhalation with thermal water may ...

    Authors: Monica Neri, Luigi Sansone, Luisa Pietrasanta, Aliaksei Kisialiou, Eloisa Cabano, Marina Martini, Matteo A. Russo, Donatella Ugolini, Marco Tafani and Stefano Bonassi

    Citation: Immunity & Ageing 2018 15:10

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  15. Content type: Review

    Human life develops and expands not only in time and space, but also in the retrograde permanent recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access...

    Authors: Angela Trovato Salinaro, Manuela Pennisi, Rosanna Di Paola, Maria Scuto, Rosalia Crupi, Maria Teresa Cambria, Maria Laura Ontario, Mario Tomasello, Maurizio Uva, Luigi Maiolino, Edward J. Calabrese, Salvatore Cuzzocrea and Vittorio Calabrese

    Citation: Immunity & Ageing 2018 15:8

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  16. Content type: Research

    Chronic increased arterial blood pressure has been associated with executive dysfunction, slowing of attention and mental processing speed, and later with memory deficits. Due to the absence of a concrete ther...

    Authors: Giuseppe Giugliano, Alessia Salemme, Sara De Longis, Marialuisa Perrotta, Valentina D’Angelosante, Alessandro Landolfi, Raffaele Izzo and Valentina Trimarco

    Citation: Immunity & Ageing 2018 15:7

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  17. Content type: Research

    A possible relationship between periodontitis and Alzheimer’s disease (AD) has been reported. However, there is limited information on the association between the Porphyromonas gingivalis (P. gingivalis) periodon...

    Authors: Ye Ding, Jingyi Ren, Hongqiang Yu, Weixian Yu and Yanmin Zhou

    Citation: Immunity & Ageing 2018 15:6

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  18. Content type: Research

    With ageing, long-standing inflammation can be destructive, contributing to development of several disorders, among these Alzheimer’s disease (AD). C-reactive protein (CRP) is a relatively stable peripheral in...

    Authors: Jessica Mira Gabin, Ingvild Saltvedt, Kristian Tambs and Jostein Holmen

    Citation: Immunity & Ageing 2018 15:4

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  19. Content type: Review

    Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hal...

    Authors: Giulia C. Leonardi, Giulia Accardi, Roberto Monastero, Ferdinando Nicoletti and Massimo Libra

    Citation: Immunity & Ageing 2018 15:1

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  20. Content type: Research

    Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in...

    Authors: Sudhir Gupta, Houfen Su, Sudhanshu Agrawal and Sastry Gollapudi

    Citation: Immunity & Ageing 2018 15:2

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  21. Content type: Review

    A better hygiene, a Westernized diet, air pollution, climate changes, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance,...

    Authors: Gabriele Di Lorenzo, Danilo Di Bona, Federica Belluzzo and Luigi Macchia

    Citation: Immunity & Ageing 2017 14:23

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  22. Content type: Research

    Individuals with a spinal cord injury (SCI), despite specialized rehabilitation and good health care, have a reduced life expectancy. Infectious diseases, such as pneumonias, infected pressure sores and urinar...

    Authors: David Pavlicek, Jörg Krebs, Simona Capossela, Alessandro Bertolo, Britta Engelhardt, Jürgen Pannek and Jivko Stoyanov

    Citation: Immunity & Ageing 2017 14:22

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  23. Content type: Review

    Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative s...

    Authors: Marco Casciaro, Eleonora Di Salvo, Elisabetta Pace, Elvira Ventura-Spagnolo, Michele Navarra and Sebastiano Gangemi

    Citation: Immunity & Ageing 2017 14:21

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  24. Content type: Research

    It has recently been shown that the leukotriene receptor antagonist montelukast rejuvenates aged brains in rats. The question is whether this commonly used, systemic, anti-asthmatic medicine has a similar effe...

    Authors: Bjørn Grinde and Bo Engdahl

    Citation: Immunity & Ageing 2017 14:20

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  25. Content type: Letter to the Editor

    In an effort to understand the mechanisms underlying the high prevalence of gastrointestinal tract disorders in old age, we investigated the expression of intestinal antimicrobial peptides in the terminal smal...

    Authors: Sarah Tremblay, Nathalie Marie Louise Côté, Guillaume Grenier, Gabriella Duclos-Lasnier, Louis-Charles Fortier, Subburaj Ilangumaran and Alfredo Menendez

    Citation: Immunity & Ageing 2017 14:19

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  26. Content type: Research

    Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhe...

    Authors: Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi and Torben Lykke Sørensen

    Citation: Immunity & Ageing 2017 14:18

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  27. Content type: Research

    The age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest ...

    Authors: Jürgen M. Bauer, Antonio De Castro, Nabil Bosco, Celine Romagny, Rebecca Diekmann, Jalil Benyacoub and Karine Vidal

    Citation: Immunity & Ageing 2017 14:17

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  28. Content type: Short report

    Many currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed con...

    Authors: Birgit Weinberger, Michael Keller and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2017 14:16

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  29. Content type: Research

    CD4+ T cells can be broadly divided into naïve and memory subsets, each of which are differentially impaired by the aging process. It is unclear if and how these differences are reflected at the transcriptomic...

    Authors: Jackson Taylor, Lindsay Reynolds, Li Hou, Kurt Lohman, Wei Cui, Stephen Kritchevsky, Charles McCall and Yongmei Liu

    Citation: Immunity & Ageing 2017 14:15

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  30. Content type: Research

    Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (E...

    Authors: Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan and Michiel G. H. Betjes

    Citation: Immunity & Ageing 2017 14:14

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  31. Content type: Research

    Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone re...

    Authors: Emanuela Galliera, Monica Gioia Marazzi, Carmine Gazzaruso, Pietro Gallotti, Adriana Coppola, Tiziana Montalcini, Arturo Pujia and Massimiliano M. Corsi Romanelli

    Citation: Immunity & Ageing 2017 14:13

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  32. Content type: Research

    Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end produ...

    Authors: Myeongjoo Son, Wook-Jin Chung, Seyeon Oh, Hyosang Ahn, Chang Hu Choi, Suntaek Hong, Kook Yang Park, Kuk Hui Son and Kyunghee Byun

    Citation: Immunity & Ageing 2017 14:12

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  33. Content type: Short report

    Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on ...

    Authors: Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral and Jesús Pintor

    Citation: Immunity & Ageing 2017 14:11

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  34. Content type: Research

    Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex ...

    Authors: Jan Olsson, Eloise Kok, Rolf Adolfsson, Hugo Lövheim and Fredrik Elgh

    Citation: Immunity & Ageing 2017 14:10

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  35. Content type: Research

    We have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (LSC) of middle-aged male rats compared to young adults suggesting a para-inflammatory state devel...

    Authors: William Galbavy, Yong Lu, Martin Kaczocha, Michelino Puopolo, Lixin Liu and Mario J. Rebecchi

    Citation: Immunity & Ageing 2017 14:9

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  36. Content type: Research

    A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccin...

    Authors: Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, D. Nigel Thomas, Eloi Kpamegan, Hanxin Lu, Gale Smith, Somia P. Hickman, Pedro Piedra and Gregory M. Glenn

    Citation: Immunity & Ageing 2017 14:8

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  37. Content type: Research

    An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodyna...

    Authors: Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A. Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli and Valeria Conti

    Citation: Immunity & Ageing 2017 14:7

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  38. Content type: Research

    The current concept of overweight/obesity is most likely related to a combination of increased caloric intake and decreased energy expenditure. Widespread inflammation, associated with both conditions, appears...

    Authors: Silvana Mara Turbino Luz Ribeiro, Laís Roquete Lopes, Guilherme de Paula Costa, Vivian Paulino Figueiredo, Deena Shrestha, Aline Priscila Batista, Roney Luiz de Carvalho Nicolato, Fernando Luiz Pereira de Oliveira, Juliana Assis Silva Gomes and Andre Talvani

    Citation: Immunity & Ageing 2017 14:6

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  39. Content type: Research

    Age-related changes of the immune system, termed immunosenescence, may underlie the increased risk of infections and morbidity in the elderly. Little is known about the effects of acute exercise on peripheral ...

    Authors: Kornelis S. M. van der Geest, Qi Wang, Thijs M. H. Eijsvogels, Hans J. P. Koenen, Irma Joosten, Elisabeth Brouwer, Maria T. E. Hopman, Joannes F. M. Jacobs and Annemieke M. H. Boots

    Citation: Immunity & Ageing 2017 14:5

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  40. Content type: Research

    NK cells are key effector lymphocytes of innate immunity provided with constitutive cytolytic activity, however, their role in human ageing is not entirely understood. The study aimed to analyze the expression...

    Authors: Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda and Zbigniew Kmieć

    Citation: Immunity & Ageing 2017 14:3

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  41. Content type: Research

    Immunosenescence is associated with several changes in adaptive and innate immune cells. Altered cytokine production is among the most prominent of these changes. The impact of age-related alterations on cytok...

    Authors: Gabriela Silveira-Nunes, Elaine Speziali, Andréa Teixeira-Carvalho, Danielle M. Vitelli-Avelar, Renato Sathler-Avelar, Taciana Figueiredo-Soares, Maria Luiza Silva, Vanessa Peruhype-Magalhães, Daniel Gonçalves Chaves, Gustavo Eustáquio Brito-Melo, Glenda Meira Cardoso, Eric Bassetti Soares, Silvana Maria Elói-Santos, Rosângela Teixeira, Dulciene Magalhães Queiroz, Rodrigo Corrêa-Oliveira…

    Citation: Immunity & Ageing 2017 14:2

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  42. Content type: Research

    Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Conseq...

    Authors: E. Vianello, E. Dozio, A. Barassi, G. Sammarco, L. Tacchini, M. M. Marrocco-Trischitta, S. Trimarchi and M. M. Corsi Romanelli

    Citation: Immunity & Ageing 2017 14:1

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  43. Content type: Research

    Upregulation of pro-inflammatory cytokines has not only been associated with increased morbidity and mortality in older adults but also has been linked to frailty. In the current study we aimed to compare the ...

    Authors: P. Van Epps, D. Oswald, P. A. Higgins, T. R. Hornick, H. Aung, R. E. Banks, B. M. Wilson, C. Burant, S. Gravenstein and D. H. Canaday

    Citation: Immunity & Ageing 2016 13:27

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    The Erratum to this article has been published in Immunity & Ageing 2017 14:4

  44. Content type: Short report

    We have recently demonstrated that single shot vaccinations against tetanus and diphtheria do not lead to long-lasting immunity against diphtheria in elderly persons despite administration at 5 year intervals....

    Authors: Marco Grasse, Andreas Meryk, Michael Schirmer, Beatrix Grubeck-Loebenstein and Birgit Weinberger

    Citation: Immunity & Ageing 2016 13:26

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  45. Content type: Review

    The acute phase protein Pentraxin 3 (PTX3) plays a non-redundant role as a soluble pattern recognition receptor for selected pathogens and it represents a rapid biomarker for primary local activation of innate...

    Authors: Francesco Fornai, Albino Carrizzo, Maurizio Forte, Mariateresa Ambrosio, Antonio Damato, Michela Ferrucci, Francesca Biagioni, Carla Busceti, Annibale A. Puca and Carmine Vecchione

    Citation: Immunity & Ageing 2016 13:25

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  46. Content type: Research

    Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stabl...

    Authors: Yun Lin, Jiewan Kim, E. Jeffrey Metter, Huy Nguyen, Thai Truong, Ana Lustig, Luigi Ferrucci and Nan-ping Weng

    Citation: Immunity & Ageing 2016 13:24

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