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  1. Alzheimer’s disease (AD) is the most common neurodegenerative disease ultimately manifesting as clinical dementia. Despite considerable effort and ample experimental data, the role of neuroinflammation related...

    Authors: Usma Munawara, Michael Catanzaro, Weili Xu, Crystal Tan, Katsuiku Hirokawa, Nabil Bosco, David Dumoulin, Abdelouahed Khalil, Anis Larbi, Simon Lévesque, Charles Ramassamy, Annelise E. Barron, Stephen Cunnane, Pascale B. Beauregard, Jean-Pierre Bellenger, Serafim Rodrigues…

    Citation: Immunity & Ageing 2021 18:29

    Content type: Research

    Published on:

  2. MicroRNAs (miRNAs) are regulatory noncoding RNAs important for many aspects of cellular processes including cell differentiation and proliferation. Functions of numerous miRNAs have been identified in T cells,...

    Authors: Chulwoo Kim, Zhongde Ye, Cornelia M. Weyand and Jörg J. Goronzy

    Citation: Immunity & Ageing 2021 18:28

    Content type: Review

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  3. Osteoarthritis (OA) is one of the most prevalent joint diseases of advanced age and is a leading cause of disability worldwide. Ageing is a major risk factor for the articular cartilage (AC) degeneration that ...

    Authors: Seth D. Thompson, Rajeswari Pichika, Richard L. Lieber and Mitra Lavasani

    Citation: Immunity & Ageing 2021 18:27

    Content type: Research

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  4. Elderly patients with cardiovascular diseases account for a large proportion of Corona virus Disease 2019(COVID-19)related deaths. COVID-19, as a new coronavirus, mainly targets the patient’s lung triggering a...

    Authors: Yuanyuan Wang, Shu-Chao Pang and Ying Yang

    Citation: Immunity & Ageing 2021 18:25

    Content type: Review

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  5. One hundred fifty million contagions, more than 3 million deaths and little more than 1 year of COVID-19 have changed our lives and our health management systems forever. Ageing is known to be one of the signi...

    Authors: María C. Martín, Aurora Jurado, Cristina Abad-Molina, Antonio Orduña, Oscar Yarce, Ana M. Navas, Vanesa Cunill, Danilo Escobar, Francisco Boix, Sergio Burillo-Sanz, María C. Vegas-Sánchez, Yesenia Jiménez-de las Pozas, Josefa Melero, Marta Aguilar, Oana Irina Sobieschi, Marcos López-Hoyos…

    Citation: Immunity & Ageing 2021 18:24

    Content type: Research

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  6. At first glance, longevity and immunity appear to be different traits that have not much in common except the fact that the immune system promotes survival upon pathogenic infection. Substantial evidence howev...

    Authors: Daniel K. Fabian, Matías Fuentealba, Handan Melike Dönertaş, Linda Partridge and Janet M. Thornton

    Citation: Immunity & Ageing 2021 18:23

    Content type: Review

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch and Andreas Thiel

    Citation: Immunity & Ageing 2021 18:22

    Content type: Correction

    Published on:

    The original article was published in Immunity & Ageing 2021 18:20

  8. Chronic infections played a detrimental role on health outcomes in the aged population, and had complex associations with lymphocyte subsets distribution. Our study aimed to explore the predictive roles of chr...

    Authors: Liang-Yu Chen, An-Chun Hwang, Chung-Yu Huang, Liang-Kung Chen, Fu-Der Wang and Yu-Jiun Chan

    Citation: Immunity & Ageing 2021 18:21

    Content type: Research

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  9. Immune ageing is a result of repetitive microbial challenges along with cell intrinsic or systemic changes occurring during ageing. Mice under ‘specific-pathogen-free’ (SPF) conditions are frequently used to a...

    Authors: Christos Nikolaou, Kerstin Muehle, Stephan Schlickeiser, Alberto Sada Japp, Nadine Matzmohr, Desiree Kunkel, Marco Frentsch and Andreas Thiel

    Citation: Immunity & Ageing 2021 18:20

    Content type: Research

    Published on:

    The Correction to this article has been published in Immunity & Ageing 2021 18:22

  10. The impact of aging on the immune system is unequivocal and results in an altered immune status termed immunosenescence. In humans, the mechanisms of immunosenescence have been examined almost exclusively in b...

    Authors: Jayaum S. Booth, Eric Goldberg, Seema A. Patil, Robin S. Barnes, Bruce D. Greenwald and Marcelo B. Sztein

    Citation: Immunity & Ageing 2021 18:19

    Content type: Research

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  11. The pathogenesis of the human demyelinating disorder multiple sclerosis (MS) involves the loss of immune tolerance to self-neuroantigens. A deterioration in immune tolerance is linked to inherent immune ageing...

    Authors: Christopher Bolton

    Citation: Immunity & Ageing 2021 18:18

    Content type: Review

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  12. The number of central and peripheral B cells and their responsiveness are decreased in aged mice. The diversity of mice central and peripheral B cell repertoires with increasing age has not been elucidated. In...

    Authors: Lina Ma, Xinxin Tao, Xiaoyan He, Peng Wang, Long Ma, Bin Shi and Xinsheng Yao

    Citation: Immunity & Ageing 2021 18:17

    Content type: Research

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  13. Individuals over the age of 65 are highly susceptible to infectious diseases, which account for one-third of deaths in this age group. Vaccines are a primary tool to combat infection, yet they are less effecti...

    Authors: Julia M. Scordo, Tucker J. Piergallini, Nicole Reuter, Colwyn A. Headley, Vida L. Hodara, Olga Gonzalez, Luis D. Giavedoni, James F. Papin and Joanne Turner

    Citation: Immunity & Ageing 2021 18:16

    Content type: Short report

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  14. Age-related changes in adaptive and innate immune cells have been associated with a decline in effective immunity and chronic, low-grade inflammation. Epigenetic, transcriptional, and functional changes in mon...

    Authors: Katherine R. Dobbs, Paula Embury, Emmily Koech, Sidney Ogolla, Stephen Munga, James W. Kazura and Arlene E. Dent

    Citation: Immunity & Ageing 2021 18:11

    Content type: Research

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  15. Psoriasis vulgaris is a skin autoimmune disease. Psoriatic patients have significantly lowered life expectancy and suffer from various comorbidities. The main goal of the study was to determine whether psoriat...

    Authors: Pavel Borsky, Marcela Chmelarova, Zdenek Fiala, Kvetoslava Hamakova, Vladimir Palicka, Jan Krejsek, Ctirad Andrys, Jan Kremlacek, Vit Rehacek, Martin Beranek, Andrea Malkova, Tereza Svadlakova, Drahomira Holmannova and Lenka Borska

    Citation: Immunity & Ageing 2021 18:10

    Content type: Research

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  16. Aging is associated with increased intrinsic B cell inflammation, decreased protective antibody responses and increased autoimmune antibody responses. The effects of aging on the metabolic phenotype of B cells...

    Authors: Daniela Frasca, Maria Romero, Denisse Garcia, Alain Diaz and Bonnie B. Blomberg

    Citation: Immunity & Ageing 2021 18:9

    Content type: Research

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  17. The resident immune population of pancreatic islets has roles in islet development, beta cell physiology, and the pathology of diabetes. These roles have largely been attributed to islet macrophages, comprisin...

    Authors: Heather C. Denroche, Stéphanie Miard, Sandrine Sallé-Lefort, Frédéric Picard and C. Bruce Verchere

    Citation: Immunity & Ageing 2021 18:8

    Content type: Research

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  18. The etiology of the low-level chronic inflammatory state associated with aging is likely multifactorial, but a number of animal and human studies have implicated a functional decline of the gastrointestinal im...

    Authors: Stephanie M. Dillon, Tezha A. Thompson, Allison J. Christians, Martin D. McCarter and Cara C. Wilson

    Citation: Immunity & Ageing 2021 18:6

    Content type: Research

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  19. Broadly, much of variance in immune system phenotype has been linked to the influence of non-heritable factors rather than genetics. In particular, two non-heritable factors: aging and human cytolomegavirus (C...

    Authors: Zheng Yan, Holden T. Maecker, Petter Brodin, Unni C. Nygaard, Shu Chen Lyu, Mark M. Davis, Kari C. Nadeau and Sandra Andorf

    Citation: Immunity & Ageing 2021 18:5

    Content type: Research

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  20. Physiological homeostasis decline, immunosenescence, and increased risk for multiple diseases, including neurodegeneration, are all hallmarks of ageing. Importantly, it is known that the ageing process is sex-...

    Authors: Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, Janna Jernigan, Nikolay M. Filipov, Jessica M. Carpenter and Jae-Kyung Lee

    Citation: Immunity & Ageing 2021 18:3

    Content type: Research

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  21. The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symp...

    Authors: Sameer Mohammad, Rafia Aziz, Saeed Al Mahri, Shuja Shafi Malik, Esraa Haji, Altaf Husain Khan, Tanvir Saleem Khatlani and Abderrezak Bouchama

    Citation: Immunity & Ageing 2021 18:1

    Content type: Review

    Published on:

  22. Obesity is associated with chronic low-grade inflammation leading to metabolic and cardiovascular diseases, but a subset of obese individuals is considered insulin sensitive (IS). The underlying pathophysiolog...

    Authors: Julia Sbierski-Kind, David Goldeck, Nikolaus Buchmann, Joachim Spranger, Hans-Dieter Volk, Elisabeth Steinhagen-Thiessen, Graham Pawelec, Ilja Demuth and Dominik Spira

    Citation: Immunity & Ageing 2020 17:40

    Content type: Research

    Published on:

  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Sara Magri, Elena Masetto, Samantha Solito, Samuela Francescato, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri and Susanna Mandruzzato

    Citation: Immunity & Ageing 2020 17:39

    Content type: Correction

    Published on:

    The original article was published in Immunity & Ageing 2020 17:27

  24. Autoimmune hemolytic anemia (AIHA) is an acquired, heterogeneous group of diseases which includes warm AIHA, cold agglutinin disease (CAD), mixed AIHA, paroxysmal cold hemoglobinuria and atypical AIHA. Current...

    Authors: Sylwia Sulimiera Michalak, Anna Olewicz-Gawlik, Joanna Rupa-Matysek, Edyta Wolny-Rokicka, Elżbieta Nowakowska and Lidia Gil

    Citation: Immunity & Ageing 2020 17:38

    Content type: Review

    Published on:

  25. Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. We estimate...

    Authors: Grace A. Noppert, Lydia Feinstein, Jennifer B. Dowd, Rebecca C. Stebbins, Emma Zang, Belinda L. Needham, Helen C. S. Meier, Amanda Simanek and Allison E. Aiello

    Citation: Immunity & Ageing 2020 17:36

    Content type: Research

    Published on:

  26. Previously, we and others have reported higher populations of circulating neutrophils in patients with neovascular age-related macular degeneration (nAMD). Neutrophil gelatinase-associated lipocalin (NGAL, als...

    Authors: Mei Chen, Nan Yang, Judith Lechner, Levente Toth, Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy and Heping Xu

    Citation: Immunity & Ageing 2020 17:35

    Content type: Research

    Published on:

  27. Since the COVID-19 outbreak an unprecedented challenge for healthcare systems around the world has been placed. In Cuba, the first case of COVID-19 was reported on March 11. Elderly with multiple comorbidities...

    Authors: Danay Saavedra, Ana Laura Añé-Kourí, Naivy Sánchez, Lázaro Manuel Filgueira, Julio Betancourt, Carlos Herrera, Leniel Manso, Elibet Chávez, Armando Caballero, Carlos Hidalgo, Geydi Lorenzo, Meylan Cepeda, Carmen Valenzuela, Mayra Ramos, Kalet León, Zaima Mazorra…

    Citation: Immunity & Ageing 2020 17:34

    Content type: Research

    Published on:

  28. Infection with SARs-COV-2 displays increasing fatality with age and underlying co-morbidity, in particular, with markers of the metabolic syndrome and diabetes, which seems to be associated with a “cytokine st...

    Authors: Alistair V. W. Nunn, Geoffrey W. Guy, Wolfgang Brysch, Stanley W. Botchway, Wayne Frasch, Edward J. Calabrese and Jimmy D. Bell

    Citation: Immunity & Ageing 2020 17:33

    Content type: Review

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  29. Immune checkpoints are crucial molecules in maintaining a proper immune balance. Even though age and sex are known to have effects on the immune system, the interplay between age, sex and immune checkpoint exp...

    Authors: Rosanne D. Reitsema, Rebeca Hid Cadena, Sander H. Nijhof, Wayel H. Abdulahad, Minke G. Huitema, Davy Paap, Elisabeth Brouwer, Annemieke M. H. Boots and Peter Heeringa

    Citation: Immunity & Ageing 2020 17:32

    Content type: Research

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  30. Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries. It is known that patients with ESRD and advanced...

    Authors: Yen-Ling Chiu, Wan-Chuan Tsai, Ruo-Wei Hung, I-Yu Chen, Kai-Hsiang Shu, Szu-Yu Pan, Feng-Jung Yang, Te-Tien Ting, Ju-Ying Jiang, Yu-Sen Peng and Yi-Fang Chuang

    Citation: Immunity & Ageing 2020 17:31

    Content type: Research

    Published on:

  31. With the ageing of the world population, osteoporosis has become a problem affecting quality of life. According to the traditional view, the causes of osteoporosis mainly include endocrine disorders, metabolic...

    Authors: Lei Zhu, Fei Hua, Wenge Ding, Kai Ding, Yige Zhang and Chenyang Xu

    Citation: Immunity & Ageing 2020 17:30

    Content type: Review

    Published on:

  32. It is important to assess the temporal reproducibility of circulating cytokines for their utility in epidemiological studies. However, existing evidence is limited and inconsistent, especially for the elderly ...

    Authors: Jing Guo, Nicole Schupf, Richard P. Mayeux and Yian Gu

    Citation: Immunity & Ageing 2020 17:29

    Content type: Research

    Published on:

  33. The immune system undergoes a myriad of changes with age. While it is known that antibody-secreting plasma and long-lived memory B cells change with age, it remains unclear how the binding profile of the circu...

    Authors: Aaron Arvey, Michael Rowe, Joseph Barten Legutki, Gang An, Anantha Gollapudi, Anna Lei, Bill Colston, Chaim Putterman, David Smith, Janelle Stiles, Theodore Tarasow and Preveen Ramamoorthy

    Citation: Immunity & Ageing 2020 17:28

    Content type: Research

    Published on:

  34. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immunosuppressive cells developing from myeloid progenitors, which are enriched in pathological conditions such as cancer, and are kno...

    Authors: Sara Magri, Elena Masetto, Samantha Solito, Samuela Francescato, Elisa Belluzzi, Assunta Pozzuoli, Antonio Berizzi, Pietro Ruggieri and Susanna Mandruzzato

    Citation: Immunity & Ageing 2020 17:27

    Content type: Short report

    Published on:

    The Correction to this article has been published in Immunity & Ageing 2020 17:39

  35. T cell discrimination of self and non-self is the foundation of the adaptive immune response, and is orchestrated by the interaction between T cell receptors (TCRs) and their cognate ligands presented by major...

    Authors: Chirag Krishna, Diego Chowell, Mithat Gönen, Yuval Elhanati and Timothy A. Chan

    Citation: Immunity & Ageing 2020 17:26

    Content type: Short report

    Published on:

  36. Altered monocyte NF-κB signaling is a possible cause of inflammaging and driver of aging, however, evidence from human aging studies is sparse. We assessed monocyte NF-κB signaling across different aging traje...

    Authors: Juliette Tavenier, Line Jee Hartmann Rasmussen, Morten Baltzer Houlind, Aino Leegaard Andersen, Inge Panum, Ove Andersen, Janne Petersen, Anne Langkilde and Jan O. Nehlin

    Citation: Immunity & Ageing 2020 17:25

    Content type: Research

    Published on:

  37. Immunologic aging leads to immune dysfunction, significantly reducing the quality of life of the elderly. Aged-related defects in early hematopoiesis result in reduced lymphoid cell development, functionally d...

    Authors: Michelle L. Ratliff, Joshua Garton, Judith A. James and Carol F. Webb

    Citation: Immunity & Ageing 2020 17:24

    Content type: Research

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  38. A central clinical question as the world deals with the COVID-19 pandemic is what the long-term sequelae for the millions of individuals will be who recover from the hyperinflammatory state characterizing COVI...

    Authors: Arsun Bektas, Shepherd H. Schurman, Claudio Franceschi and Luigi Ferrucci

    Citation: Immunity & Ageing 2020 17:23

    Content type: Opinion

    Published on:

  39. The SARS-CoV-2 infection has widely spread to become the greatest public health challenge to date, the COVID-19 pandemic. Different fatality rates among countries are probably due to non-standardized records b...

    Authors: Aurora Jurado, María C. Martín, Cristina Abad-Molina, Antonio Orduña, Alba Martínez, Esther Ocaña, Oscar Yarce, Ana M. Navas, Antonio Trujillo, Luis Fernández, Esther Vergara, Beatriz Rodríguez, Bibiana Quirant, Eva Martínez-Cáceres, Manuel Hernández, Janire Perurena-Prieto…

    Citation: Immunity & Ageing 2020 17:22

    Content type: Research

    Published on:

  40. With advancing age, the composition of leukocyte subpopulations in peripheral blood is known to change, but how this change differs between men and women and how it relates to frailty is poorly understood. Our...

    Authors: Leonard Daniël Samson, A. Mieke H. Boots, José A. Ferreira, H. Susan J. Picavet, Lia G. H. de Rond, Mary-lène de Zeeuw-Brouwer, W. M. Monique Verschuren, Anne-Marie Buisman and Peter Engelfriet

    Citation: Immunity & Ageing 2020 17:20

    Content type: Research

    Published on:

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