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Immunity & Ageing

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  1. Content type: Review

    Human life develops and expands not only in time and space, but also in the retrograde permanent recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access...

    Authors: Angela Trovato Salinaro, Manuela Pennisi, Rosanna Di Paola, Maria Scuto, Rosalia Crupi, Maria Teresa Cambria, Maria Laura Ontario, Mario Tomasello, Maurizio Uva, Luigi Maiolino, Edward J. Calabrese, Salvatore Cuzzocrea and Vittorio Calabrese

    Citation: Immunity & Ageing 2018 15:8

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  2. Content type: Research

    Chronic increased arterial blood pressure has been associated with executive dysfunction, slowing of attention and mental processing speed, and later with memory deficits. Due to the absence of a concrete ther...

    Authors: Giuseppe Giugliano, Alessia Salemme, Sara De Longis, Marialuisa Perrotta, Valentina D’Angelosante, Alessandro Landolfi, Raffaele Izzo and Valentina Trimarco

    Citation: Immunity & Ageing 2018 15:7

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  3. Content type: Research

    A possible relationship between periodontitis and Alzheimer’s disease (AD) has been reported. However, there is limited information on the association between the Porphyromonas gingivalis (P. gingivalis) periodon...

    Authors: Ye Ding, Jingyi Ren, Hongqiang Yu, Weixian Yu and Yanmin Zhou

    Citation: Immunity & Ageing 2018 15:6

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  4. Content type: Research

    With ageing, long-standing inflammation can be destructive, contributing to development of several disorders, among these Alzheimer’s disease (AD). C-reactive protein (CRP) is a relatively stable peripheral in...

    Authors: Jessica Mira Gabin, Ingvild Saltvedt, Kristian Tambs and Jostein Holmen

    Citation: Immunity & Ageing 2018 15:4

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  5. Content type: Review

    Ageing is the major risk factor for cancer development. Hallmark of the ageing process is represented by inflammaging, which is a chronic and systemic low-grade inflammatory process. Inflammation is also a hal...

    Authors: Giulia C. Leonardi, Giulia Accardi, Roberto Monastero, Ferdinando Nicoletti and Massimo Libra

    Citation: Immunity & Ageing 2018 15:1

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  6. Content type: Research

    Progressive T cell decline in aged humans is associated with a deficiency of naïve (TN) and central memory (TCM) T cells. We have previously reported increased Tumor necrosis factor-α (TNF-α)-induced apoptosis in...

    Authors: Sudhir Gupta, Houfen Su, Sudhanshu Agrawal and Sastry Gollapudi

    Citation: Immunity & Ageing 2018 15:2

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  7. Content type: Review

    A better hygiene, a Westernized diet, air pollution, climate changes, and other factors that influence host microbiota, a key player in the induction and maintenance of immunoregulatory circuits and tolerance,...

    Authors: Gabriele Di Lorenzo, Danilo Di Bona, Federica Belluzzo and Luigi Macchia

    Citation: Immunity & Ageing 2017 14:23

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  8. Content type: Research

    Individuals with a spinal cord injury (SCI), despite specialized rehabilitation and good health care, have a reduced life expectancy. Infectious diseases, such as pneumonias, infected pressure sores and urinar...

    Authors: David Pavlicek, Jörg Krebs, Simona Capossela, Alessandro Bertolo, Britta Engelhardt, Jürgen Pannek and Jivko Stoyanov

    Citation: Immunity & Ageing 2017 14:22

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  9. Content type: Review

    Aging is an agglomerate of biological long-lasting processes that result being inevitable. Main actors in this scenario are both long-term inflammation and oxidative stress. It has been proved that oxidative s...

    Authors: Marco Casciaro, Eleonora Di Salvo, Elisabetta Pace, Elvira Ventura-Spagnolo, Michele Navarra and Sebastiano Gangemi

    Citation: Immunity & Ageing 2017 14:21

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  10. Content type: Research

    It has recently been shown that the leukotriene receptor antagonist montelukast rejuvenates aged brains in rats. The question is whether this commonly used, systemic, anti-asthmatic medicine has a similar effe...

    Authors: Bjørn Grinde and Bo Engdahl

    Citation: Immunity & Ageing 2017 14:20

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  11. Content type: Letter to the Editor

    In an effort to understand the mechanisms underlying the high prevalence of gastrointestinal tract disorders in old age, we investigated the expression of intestinal antimicrobial peptides in the terminal smal...

    Authors: Sarah Tremblay, Nathalie Marie Louise Côté, Guillaume Grenier, Gabriella Duclos-Lasnier, Louis-Charles Fortier, Subburaj Ilangumaran and Alfredo Menendez

    Citation: Immunity & Ageing 2017 14:19

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  12. Content type: Research

    Neutrophil dysfunction plays a key role in the development of diseases characterized by inflammation and angiogenesis. Here, we studied the systemic expression of neutrophil markers reflecting activation, adhe...

    Authors: Marie Krogh Nielsen, Sven Magnus Hector, Kelly Allen, Yousif Subhi and Torben Lykke Sørensen

    Citation: Immunity & Ageing 2017 14:18

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  13. Content type: Research

    The age-related dysregulation of the immune system in older persons results in reduced responses to vaccination and greater susceptibility to infection, especially in frail individuals who suffer the greatest ...

    Authors: Jürgen M. Bauer, Antonio De Castro, Nabil Bosco, Celine Romagny, Rebecca Diekmann, Jalil Benyacoub and Karine Vidal

    Citation: Immunity & Ageing 2017 14:17

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  14. Content type: Short report

    Many currently used vaccines are less immunogenic in the elderly compared to young adults. The impact of latent infection with Cytomegalovirus (CMV) on vaccine-induced antibody responses has been discussed con...

    Authors: Birgit Weinberger, Michael Keller and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2017 14:16

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  15. Content type: Research

    CD4+ T cells can be broadly divided into naïve and memory subsets, each of which are differentially impaired by the aging process. It is unclear if and how these differences are reflected at the transcriptomic...

    Authors: Jackson Taylor, Lindsay Reynolds, Li Hou, Kurt Lohman, Wei Cui, Stephen Kritchevsky, Charles McCall and Yongmei Liu

    Citation: Immunity & Ageing 2017 14:15

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  16. Content type: Research

    Patients with end-stage renal disease (ESRD) have an impaired immune response with a prematurely aged T-cell system. Mitogen-activated protein kinases (MAPKs) including extracellular signal-regulated kinase (E...

    Authors: Ling Huang, Nicolle H. R. Litjens, Nynke M. Kannegieter, Mariska Klepper, Carla C. Baan and Michiel G. H. Betjes

    Citation: Immunity & Ageing 2017 14:14

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  17. Content type: Research

    Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone re...

    Authors: Emanuela Galliera, Monica Gioia Marazzi, Carmine Gazzaruso, Pietro Gallotti, Adriana Coppola, Tiziana Montalcini, Arturo Pujia and Massimiliano M. Corsi Romanelli

    Citation: Immunity & Ageing 2017 14:13

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  18. Content type: Research

    Much evidence indicates receptor for advanced glycation end products (RAGE) related inflammation play essential roles during aging. However, the majority of studies have focused on advanced glycation end produ...

    Authors: Myeongjoo Son, Wook-Jin Chung, Seyeon Oh, Hyosang Ahn, Chang Hu Choi, Suntaek Hong, Kook Yang Park, Kuk Hui Son and Kyunghee Byun

    Citation: Immunity & Ageing 2017 14:12

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  19. Content type: Short report

    Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on ...

    Authors: Almudena Crooke, Juan Martínez-Henández, Joaquín Martínez-López, Alfonso Cruz-Jentoft, Fernando Huete-Toral and Jesús Pintor

    Citation: Immunity & Ageing 2017 14:11

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  20. Content type: Research

    Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex ...

    Authors: Jan Olsson, Eloise Kok, Rolf Adolfsson, Hugo Lövheim and Fredrik Elgh

    Citation: Immunity & Ageing 2017 14:10

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  21. Content type: Research

    We have previously reported elevated expression of multiple pro-inflammatory markers in the lumbar spinal cord (LSC) of middle-aged male rats compared to young adults suggesting a para-inflammatory state devel...

    Authors: William Galbavy, Yong Lu, Martin Kaczocha, Michelino Puopolo, Lixin Liu and Mario J. Rebecchi

    Citation: Immunity & Ageing 2017 14:9

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  22. Content type: Research

    A preventative strategy for Respiratory Syncytial Virus (RSV) infection constitutes an under-recognized unmet medical need among older adults. Four formulations of a novel recombinant RSV F nanoparticle vaccin...

    Authors: Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, D. Nigel Thomas, Eloi Kpamegan, Hanxin Lu, Gale Smith, Somia P. Hickman, Pedro Piedra and Gregory M. Glenn

    Citation: Immunity & Ageing 2017 14:8

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  23. Content type: Research

    An exercise-based Cardiac Rehabilitation Programme (CRP) is established as adjuvant therapy in heart failure (HF), nevertheless it is underutilized, especially in the elderly. While the functional and hemodyna...

    Authors: Giusy Russomanno, Graziamaria Corbi, Valentina Manzo, Nicola Ferrara, Giuseppe Rengo, Annibale A. Puca, Salvatore Latte, Albino Carrizzo, Maria Consiglia Calabrese, Ramaroson Andriantsitohaina, Walter Filippelli, Carmine Vecchione, Amelia Filippelli and Valeria Conti

    Citation: Immunity & Ageing 2017 14:7

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