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  1. Frailty, a clinical syndrome commencing at midlife, is a risk for morbidity and mortality. Little is known about the factors that contribute to the chronic inflammatory state associated with frailty. Extracell...

    Authors: Anjali M. Byappanahalli, Nicole Noren Hooten, Mya Vannoy, Nicolle A. Mode, Ngozi Ezike, Alan B. Zonderman and Michele K. Evans
    Citation: Immunity & Ageing 2023 20:6
  2. There is increasing concern that cancer and cancer treatment accelerate aging and the associated cognitive decline. We showed recently that treatment of 9-month-old male mice with cisplatin causes cognitive de...

    Authors: Miriam Zamorano, Jenolyn F. Alexander, Desiree Catania, Shruti Dharmaraj, Annemieke Kavelaars and Cobi J. Heijnen
    Citation: Immunity & Ageing 2023 20:5
  3. Immune responses to COVID-19 mRNA vaccines have not been well characterized in frail older adults. We postulated that frailty is associated with impaired antibody and cellular mRNA vaccine responses.

    Authors: Charles T. Semelka, Michael E. DeWitt, Maria W. Blevins, Beth C. Holbrook, John W. Sanders and Martha A. Alexander-Miller
    Citation: Immunity & Ageing 2023 20:4
  4. The diffuse distribution of nicotinic cholinergic receptors (nAChRs) in both brain and peripheral immune cells points out their involvement in several pathological conditions. Indeed, the deregulated function ...

    Authors: E. Costantini, C. Carrarini, P. Borrelli, M. De Rosa, D. Calisi, S. Consoli, D. D’Ardes, F. Cipollone, M. Di Nicola, M. Onofrj, M. Reale and L. Bonanni
    Citation: Immunity & Ageing 2023 20:3
  5. The equine population in the United States and worldwide now includes a higher percentage of geriatric horses than ever previously recorded, and as methods to treat and manage elderly equids are developed and ...

    Authors: Sally DeNotta and Dianne McFarlane
    Citation: Immunity & Ageing 2023 20:2
  6. Diet and chronic inflammation might play a major role in the pathogenesis of mild cognitive impairment (MCI). In addition, peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mt...

    Authors: Qian Liu, Zhenshu Li, Ling Huang, Dezheng Zhou, Jingzhu Fu, Huilian Duan, Zehao Wang, Tong Yang, Jing Zhao, Wen Li, Huan Liu, Fei Ma, Changqing Sun, Guangshun Wang, Yue Du, Meilin Zhang…
    Citation: Immunity & Ageing 2023 20:1
  7. Obesity rates are increasing worldwide. Obesity leads to many complications, including predisposing individuals to the development of cognitive impairment as they age. Immune dysregulation, including inflammag...

    Authors: Rosemary E. Henn, Sarah E. Elzinga, Emily Glass, Rachel Parent, Kai Guo, Adam A. Allouch, Faye E. Mendelson, John Hayes, Ian Webber-Davis, Geoffery G. Murphy, Junguk Hur and Eva L. Feldman
    Citation: Immunity & Ageing 2022 19:67
  8. CD8+ T cells play an important role in host defense against infections and malignancies as well as contribute to the development of inflammatory disorders. Alterations in the frequency of naïve and memory CD8+ T ...

    Authors: Min Sun Shin, Hong-Jai Park, Juan Young and Insoo Kang
    Citation: Immunity & Ageing 2022 19:66
  9. The risk for symptomatic COVID-19 requiring hospitalization is higher in the older population. The course of the disease in hospitalised older patients may show significant variation, from mild to severe illne...

    Authors: M. Cardelli, E. Pierpaoli, F. Marchegiani, F. Marcheselli, F. Piacenza, R. Giacconi, R. Recchioni, T. Casoli, P. Stripoli, M. Provinciali, G. Matacchione, A. Giuliani, D. Ramini, J. Sabbatinelli, M. Bonafè, M. Di Rosa…
    Citation: Immunity & Ageing 2022 19:65
  10. Obesity is characterized by an elevated amount of fat and energy storage in the adipose tissue (AT) and is believed to be the root cause of many metabolic diseases (MDs). Obesity is associated with low-grade c...

    Authors: Ahmed Rakib, Sonia Kiran, Mousumi Mandal and Udai P. Singh
    Citation: Immunity & Ageing 2022 19:64
  11. It has been widely accepted that monocytes are one of the central mediators contributing to inflammaging. However, it remains unclear whether aged monocytes, similar to aged T cells, have characteristics of hy...

    Authors: Yu Cao, Yang Fan, Fangyuan Li, Yu Hao, Yaxian Kong, Chen Chen, Xing Hao, Dannuo Han, Guoli Li, Zengtao Wang, Chuan Song, Junyan Han and Hui Zeng
    Citation: Immunity & Ageing 2022 19:63
  12. Systemic chronic inflammation occurs with age. The association of the leukocyte mitochondrial DNA copy number, a measure of mitochondrial function in aging, with the temporal profile of serum high-sensitivity ...

    Authors: I-Chien Wu, Chin-San Liu, Wen-Ling Cheng, Ta-Tsung Lin, Hui-Ling Chen, Pei-Fen Chen, Ray-Chin Wu, Chen-Wei Huang, Chao A. Hsiung and Chih-Cheng Hsu
    Citation: Immunity & Ageing 2022 19:62
  13. Authors: Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard…
    Citation: Immunity & Ageing 2022 19:61

    The original article was published in Immunity & Ageing 2022 19:57

  14. Traumatic injury elicits a hyperinflammatory response and remodelling of the immune system leading to immuneparesis. This study aimed to evaluate whether traumatic injury results in a state of prematurely aged...

    Authors: Mark A. Foster, Conor Bentley, Jon Hazeldine, Animesh Acharjee, Ornit Nahman, Shai S. Shen-Orr, Janet M. Lord and Niharika A. Duggal
    Citation: Immunity & Ageing 2022 19:60
  15. The sequestering of oxidation-modified low-density lipoprotein by macrophages results in the accumulation of fatty deposits within the walls of arteries. Necrosis of these cells causes a release of intercellul...

    Authors: Joshua A. Taylor, Mark A. Hutchinson, Patricia J. Gearhart and Robert W. Maul
    Citation: Immunity & Ageing 2022 19:59
  16. Immunosenescence is the deterioration of the innate and adaptive immune systems associated with aging and is primarily characterized by a reduction in T cell production and accumulation of atypical subsets. Ag...

    Authors: Mingxuan Chi, Zijun Tian, Kuai Ma, Yunlong Li, Li Wang, Moussa Ide Nasser and Chi Liu
    Citation: Immunity & Ageing 2022 19:58
  17. Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied thr...

    Authors: Mateus V. de Castro, Monize V. R. Silva, Michel S. Naslavsky, Marilia O. Scliar, Kelly Nunes, Maria Rita Passos-Bueno, Erick C. Castelli, Jhosiene Y. Magawa, Flávia L. Adami, Ana I. S. Moretti, Vivian L. de Oliveira, Silvia B. Boscardin, Edecio Cunha-Neto, Jorge Kalil, Emmanuelle Jouanguy, Paul Bastard…
    Citation: Immunity & Ageing 2022 19:57

    The Correction to this article has been published in Immunity & Ageing 2022 19:61

  18. Immunosenescence is an age-dependent decline in immune functions and hallmark of aging in diverse species, ranging from invertebrates to mammals. However, identifying the factors responsible for immunosenescen...

    Authors: Sieun S. Kim, Jooyeon Sohn and Seung-Jae V. Lee
    Citation: Immunity & Ageing 2022 19:56
  19. Regulation of endometrial (EM) CD8+ T cells, which provide protection through cell-mediated cytotoxicity, is essential for successful reproduction, and protection against sexually transmitted infections and po...

    Authors: Zheng Shen, Mickey V. Patel, Marta Rodriguez-Garcia and Charles R. Wira
    Citation: Immunity & Ageing 2022 19:55
  20. Cytomegalovirus (CMV) infection leads to effector memory CD8+ T cell expansion and is associated with immune dysfunction in older adults. However, the molecular alterations of CMV-specific CD8+ T cells in CMV inf...

    Authors: Jian Lu, Guobing Chen, Arina Sorokina, Thomas Nguyen, Tonya Wallace, Cuong Nguyen, Christopher Dunn, Stephanie Wang, Samantha Ellis, Guixin Shi, Julia McKelvey, Alexei Sharov, Yu-Tsueng Liu, Jonathan Schneck and Nan-ping Weng
    Citation: Immunity & Ageing 2022 19:54
  21. Ageing is a complex phenomenon that leads to decreased proliferative activity, loss of function of the cells, and cellular senescence. Senescence of the immune system exacerbates individual’s immune response, ...

    Authors: Michał Cezary Czarnogórski, Justyna Sakowska, Mateusz Maziewski, Maciej Zieliński, Agnieszka Piekarska, Igor Obuchowski, Mikołaj Młyński, Magdalena Dutka, Alicja Sadowska-Klasa, Ewa Zarzycka, Maria Bieniaszewska, Piotr Trzonkowski, Jacek M. Witkowski, Andrzej Hellmann, Katarzyna Ruckemann-Dziurdzińska and Jan M. Zaucha
    Citation: Immunity & Ageing 2022 19:51
  22. Patients with systemic lupus erythematosus (SLE) are highly susceptible to infection and cardiovascular events, suggesting that chronic antigenic stimulation may accelerate premature aging in SLE patients. Pre...

    Authors: Ti Zhang, Xin Liu, Yue Zhao, Xiaodong Xu, Yaoyang Liu and Xin Wu
    Citation: Immunity & Ageing 2022 19:50
  23. Frailty is a complex, multi-dimensional age-related syndrome that increases the susceptibility to adverse health outcomes and poor quality of life. A growing consensus supports the contribution of chronic infl...

    Authors: Orietta Pansarasa, Maria Chiara Mimmi, Annalisa Davin, Marta Giannini, Antonio Guaita and Cristina Cereda
    Citation: Immunity & Ageing 2022 19:49
  24. Aging and obesity are high risk factors for several conditions and diseases. They are both associated with systemic inflammation and they are both ameliorated by a healthy life style, suggesting that they may ...

    Authors: Daniela Frasca
    Citation: Immunity & Ageing 2022 19:48
  25. Vaccine efficiency has a significant role in the public perception of vaccination. The current study was designed to evaluate the efficacy of COVID-19 vaccines (AZD-1222, Sputnik-V, Sinopharm, and Covaxin) and...

    Authors: Hamed Zare, Hadis Rezapour, Alireza Fereidouni, Saboura Nikpour, Sara Mahmoudzadeh, Simon G Royce and Mohammad Fereidouni
    Citation: Immunity & Ageing 2022 19:47
  26. Vaccination is important in influenza prevention but the immune response wanes with age. The circadian nature of the immune system suggests that adjusting the time of vaccination may provide an opportunity to ...

    Authors: Yihao Liu, Hui Zhang, Gang Yuan, Mi Yao, Bin Li, Jianying Chen, Yuling Fan, Ruohui Mo, Fenghua Lai, Xinwen Chen, Mengyuan Li, Binfeng Chen, Janet M. Lord, Sui Peng, KarKeung Cheng and Haipeng Xiao
    Citation: Immunity & Ageing 2022 19:46
  27. Cognitive symptoms of major depressive disorder, such as negative cognitive bias, are more prevalent in women than in men. Cognitive bias involves pattern separation which requires hippocampal neurogenesis and...

    Authors: Travis E. Hodges, Stephanie E. Lieblich, Rebecca K. Rechlin and Liisa A. M. Galea
    Citation: Immunity & Ageing 2022 19:43
  28. Assessment of immune function is of key importance in recognition of disease or healthy status, which still faces challenge in clinical practice. We conducted a 10-center study to investigate lymphocyte parame...

    Authors: Wei Liu, Jie Xu, Qiyao Pu, Mingwei Lan, Xiaolu Zhang, Yufeng Gu, Ying Wang, Fan Zheng, Jingjing Qian, Chunxue Fan, Jun Sui, Yanli Xu, Yongchen Zhang, Jing Luo, Xiangyang Lin, Shaorui Shi…
    Citation: Immunity & Ageing 2022 19:42
  29. Monocytes are a heterogenous population of immune cells whose subsets and functions become substantially dysregulated with advanced age. Although much of our current understanding of the age-related changes in...

    Authors: Ryan G. Snodgrass, Xiaowen Jiang and Charles B. Stephensen
    Citation: Immunity & Ageing 2022 19:41
  30. Aging is accompanied by a dramatic decline in the interleukin (IL)-2 production capacity of human immune cells, thus making seniors more susceptible to a variety of age-related diseases. A common cause of impa...

    Authors: Bastian Robinson Baarz, Thea Laurentius, Jana Wolf, Inga Wessels, Leo Cornelius Bollheimer and Lothar Rink
    Citation: Immunity & Ageing 2022 19:40
  31. Biological aging represents a loss of integrity and functionality of physiological systems over time. While associated with an enhanced risk of adverse outcomes such as hospitalization, disability and death fo...

    Authors: Chris P. Verschoor, Daniel W. Belsky, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, Janet E. McElhaney and George A. Kuchel
    Citation: Immunity & Ageing 2022 19:39
  32. Age and comorbidity are the main determinants of COVID-19 outcome. Shorter leukocyte telomere length (TL), a hallmark of biological aging, has been associated with worse COVID-19 outcomes. We sought to determi...

    Authors: Miriam Retuerto, Ana Lledó, Beatriz Fernandez-Varas, Rosa Guerrero-López, Alicia Usategui, Antonio Lalueza, Rocío García-García, Esther Mancebo, Estela Paz-Artal, Leandro Sastre, Rosario Perona and José L. Pablos
    Citation: Immunity & Ageing 2022 19:38
  33. Traditionally, the immune system is understood to be divided into discrete cell types that are identified via surface markers. While some cell type distinctions are no doubt discrete, others may in fact vary o...

    Authors: G. Provost, F. B. Lavoie, A. Larbi, TP. Ng, C. Tan Tze Ying, M. Chua, T. Fulop and A. A. Cohen
    Citation: Immunity & Ageing 2022 19:35
  34. The immune cell compartment of the mammalian brain changes dramatically and peripheral T cells infiltrate the brain parenchyma during normal aging. However, the mechanisms underlying age-related T cell infiltr...

    Authors: Xiaotao Zhang, Rui Wang, Haoran Chen, Chenghao Jin, Ziyang Jin, Jianan Lu, Liang Xu, Yunrong Lu, Jianmin Zhang and Ligen Shi
    Citation: Immunity & Ageing 2022 19:34
  35. Cellular changes in adaptive immune system accompany the process of aging and contribute to an aging-related immune phenotype (ARIP) characterized by decrease in naïve T-cells (TN) and increase in memory T-cells ...

    Authors: Ramya Ramasubramanian, Helen C. S. Meier, Sithara Vivek, Eric Klopack, Eileen M. Crimmins, Jessica Faul, Janko Nikolich-Žugich and Bharat Thyagarajan
    Citation: Immunity & Ageing 2022 19:33
  36. Telomerase, the enzyme capable of elongating telomeres, is usually restricted in human somatic cells, which contributes to progressive telomere shortening with cell-division and ageing. T and B-cells cells are...

    Authors: Pam S. Ellis, Raquel R. Martins, Emily J. Thompson, Asma Farhat, Stephen A. Renshaw and Catarina M. Henriques
    Citation: Immunity & Ageing 2022 19:31
  37. Authors: Grace M. Niemiro, Adriana M. Coletta, Nadia H. Agha, Preteesh Leo Mylabathula, Forrest L. Baker, Abenaa M. Brewster, Therese B. Bevers, Enrique Fuentes-Mattei, Karen Basen-Engquist, Emmanuel Katsanis, Susan C. Gilchrist and Richard J. Simpson
    Citation: Immunity & Ageing 2022 19:30

    The original article was published in Immunity & Ageing 2022 19:17

  38. Grass carp are an important farmed fish in China that are infected by many pathogens, especially grass carp reovirus (GCRV). Notably, grass carp showed age-dependent susceptibility to GCRV; that is, grass carp...

    Authors: Libo He, Xinyu Liang, Qian Wang, Cheng Yang, Yongming Li, Lanjie Liao, Zuoyan Zhu and Yaping Wang
    Citation: Immunity & Ageing 2022 19:28
  39. Influenza causes a serious infection in older individuals who are at the highest risk for mortality from this virus. Changes in the immune system with age are well known. This study used transcriptomic analysi...

    Authors: Ana M. Hernandez, Jim A. Mossman, Franklin R. Toapanta, Dana M. Previte, Ted M. Ross and Gerard J. Nau
    Citation: Immunity & Ageing 2022 19:27
  40. With increasing age, overall health declines while systemic levels of inflammatory mediators tend to increase. Although the underlying mechanisms are poorly understood, there is a wealth of data suggesting tha...

    Authors: Emilie Picard, Sarah Armstrong, Melissa K. Andrew, Laura Haynes, Mark Loeb, Graham Pawelec, George A. Kuchel, Janet E. McElhaney and Chris P. Verschoor
    Citation: Immunity & Ageing 2022 19:26
  41. Understanding mechanisms of pathologic neuroinflammation is essential for improving outcomes after central nervous system infections. Brain tissue-resident memory T cells (bTRM) are recruited during central nervo...

    Authors: Benjamin R. Cassidy, William E. Sonntag, Pieter J. M. Leenen and Douglas A. Drevets
    Citation: Immunity & Ageing 2022 19:25
  42. The existence of SARS-CoV-2 variants of concern (VOCs) in association with evidence of breakthrough infections despite vaccination resulted in the need for vaccine boosting. In elderly individuals, information...

    Authors: Chalerm Liwsrisakun, Supansa Pata, Witida Laopajon, Nuchjira Takheaw, Warawut Chaiwong, Juthamas Inchai, Chaicharn Pothirat, Chaiwat Bumroongkit, Athavudh Deesomchok, Theerakorn Theerakittikul, Atikun Limsukon, Pattraporn Tajarernmuang, Nutchanok Niyatiwatchanchai, Konlawij Trongtrakul, Kantinan Chuensirikulchai and Watchara Kasinrerk
    Citation: Immunity & Ageing 2022 19:24

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