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  1. Content type: Review

    The age-related dysregulation and decline of the immune system—collectively termed “immunosenescence”—has been generally associated with an increased susceptibility to infectious pathogens and poor vaccine res...

    Authors: Stephen N. Crooke, Inna G. Ovsyannikova, Gregory A. Poland and Richard B. Kennedy

    Citation: Immunity & Ageing 2019 16:25

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  2. Content type: Short report

    T cells are fundamental effector cells against viruses and cancers that can be divided into different subsets based on their long-term immune protection and immediate immune response effects. The percentage an...

    Authors: Mingde Li, Danlin Yao, Xiangbo Zeng, Dimitri Kasakovski, Yikai Zhang, Shaohua Chen, Xianfeng Zha, Yangqiu Li and Ling Xu

    Citation: Immunity & Ageing 2019 16:24

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  3. Content type: Research

    Influenza virus infection causes significant morbidity and mortality worldwide. Humans fail to make a universally protective memory response to influenza A because of high mutation rates in the immune-dominant...

    Authors: Lynn Bimler, Amber Y. Song, Duy T. Le, Ashleigh Murphy Schafer and Silke Paust

    Citation: Immunity & Ageing 2019 16:23

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  4. Content type: Research

    Aging is known to induce immunosenescence, resulting in alterations in both the innate and adaptive immune system. Here we evaluated the effects of aging on B cell subsets in peripheral blood of 155 immunologi...

    Authors: Alice F. Muggen, Madelon de Jong, Ingrid L. M. Wolvers-Tettero, Martine J. Kallemeijn, Cristina Teodósio, Nikos Darzentas, Ralph Stadhouders, Hanna IJspeert, Mirjam van der Burg, Wilfred FJ van IJcken, Jan A. N. Verhaar, Wayel H. Abdulahad, Elisabeth Brouwer, Annemieke M. H. Boots, Rudi W. Hendriks, Jacques J. M. van Dongen…

    Citation: Immunity & Ageing 2019 16:22

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  5. Content type: Research

    Antigen-experienced immune cells migrate back to the bone marrow (BM), where they are maintained in BM survival niches for an extended period. The composition of T cell subpopulations in the BM changes with ag...

    Authors: Erin Naismith, Luca Pangrazzi, Marco Grasse, Michael Keller, Carina Miggitsch, Birgit Weinberger, Klemens Trieb and Beatrix Grubeck-Loebenstein

    Citation: Immunity & Ageing 2019 16:21

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  6. Content type: Research

    Peripheral blood mononuclear cells (PBMCs) are implicated in the pathogenesis of age-related macular degeneration (AMD). We here mapped the global gene transcriptome of PBMCs from patients with different clini...

    Authors: Yousif Subhi, Marie Krogh Nielsen, Christopher Rue Molbech, Charlotte Liisborg, Helle Bach Søndergaard, Finn Sellebjerg and Torben Lykke Sørensen

    Citation: Immunity & Ageing 2019 16:20

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  7. Content type: Research

    Immunosenescence, i.e. the aging-associated decline of the capacity of the immune system, is characterized by several distinct changes in the number and functions of the immune cells. In the case of B cells, t...

    Authors: Tapio Nevalainen, Arttu Autio, Laura Kummola, Tanja Salomaa, Ilkka Junttila, Marja Jylhä and Mikko Hurme

    Citation: Immunity & Ageing 2019 16:19

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  8. Content type: Research

    Systemic infection is associated with long-term cognitive deficits and functional decline. In this study we hypothesized that severe systemic inflammation leads to a neuroinflammatory response that is characte...

    Authors: D. Westhoff, J. Y. Engelen-Lee, I. C. M. Hoogland, E. M. A. Aronica, D. J. van Westerloo, D. van de Beek and W. A. van Gool

    Citation: Immunity & Ageing 2019 16:18

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  9. Content type: Research

    Ageing is associated with a decline in immune function termed immunosenescence. This process is characterized amongst others by less naive T-cells and more senescent phenotypes, which have been implicated in t...

    Authors: Hung Cao Dinh, Ivan Bautmans, Ingo Beyer, Oscar Okwudiri Onyema, Keliane Liberman, Liza De Dobbeleer, Wim Renmans, Sam Vander Meeren, Kristin Jochmans, Andreas Delaere, Veerle Knoop and Rose Njemini

    Citation: Immunity & Ageing 2019 16:17

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  10. Content type: Research

    Age is a significant risk factor for recurrent urinary tract (rUTI) infections, but the clinical picture is often confused in older patients who also present with asymptomatic bacteriuria (ASB). Yet, how bacte...

    Authors: Lauren K. L. Drage, Wendy Robson, Catherine Mowbray, Ased Ali, John D. Perry, Katherine E. Walton, Christopher Harding, Robert Pickard, Judith Hall and Phillip D. Aldridge

    Citation: Immunity & Ageing 2019 16:16

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  11. Content type: Research

    Cytokines, chemokines, C-reactive proteins (CRP) and ferritin are known inflammatory markers. However, cytokines such as interleukin (IL-1β), (IL-6) and tumour necrosis factor (TNF-α) have been reported to int...

    Authors: Bolaji Lilian Ilesanmi-Oyelere, Linda Schollum, Barbara Kuhn-Sherlock, Michelle McConnell, Sonya Mros, Jane Coad, Nicole C. Roy and Marlena Cathorina Kruger

    Citation: Immunity & Ageing 2019 16:15

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  12. Content type: Research

    Seasonal influenza virus infection is a significant cause of morbimortality in the elderly. However, there is poor vaccine efficacy in this population due to immunosenescence. We aimed to explore several homeo...

    Authors: I. Herrero-Fernández, I. Rosado-Sánchez, A. I. Álvarez-Ríos, M. I. Galvá, M. De Luna-Romero, S. Sanbonmatsu-Gámez, M. Pérez-Ruiz, J. M. Navarro-Marí, A. Carrillo-Vico, B. Sánchez, R. Ramos, J. Cañizares, M. Leal and Y. M. Pacheco

    Citation: Immunity & Ageing 2019 16:14

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  13. Content type: Research

    T cells play a key role in controlling viral infections; however, the underlying mechanisms regulating their functions during human viral infections remain incompletely understood. Here, we used CD4 T cells de...

    Authors: Yingjie Ji, Xindi Dang, Lam Ngoc Thao Nguyen, Lam Nhat Nguyen, Juan Zhao, Dechao Cao, Sushant Khanal, Madison Schank, Xiao Y. Wu, Zheng D. Morrison, Yue Zou, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman and Zhi Q. Yao

    Citation: Immunity & Ageing 2019 16:12

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  14. Content type: Research

    There is a growing interest in the role of inflammageing for chronic disease development. Cytokines are potent soluble immune mediators that can be used as target biomarkers of inflammageing; however, their me...

    Authors: Liselot Koelman, Olga Pivovarova-Ramich, Andreas F. H. Pfeiffer, Tilman Grune and Krasimira Aleksandrova

    Citation: Immunity & Ageing 2019 16:11

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  15. Content type: Research

    Exosomes are lipid-bilayer enclosed nano-sized vesicles that transfer functional cellular proteins, mRNA and miRNAs. Mesenchymal stem cells (MSCs) derived exosomes have been demonstrated to prevent memory defi...

    Authors: Guo-hong Cui, Hai-dong Guo, Han Li, Yu Zhai, Zhang-bin Gong, Jing Wu, Jian-sheng Liu, You-rong Dong, Shuang-xing Hou and Jian-ren Liu

    Citation: Immunity & Ageing 2019 16:10

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  16. Content type: Short report

    Older age at organ transplantation is associated with increased risk of infection and malignancy but reduced risk of cellular rejection. De novo donor-specific anti-HLA antibodies (dnDSA), are key biomarkers asso...

    Authors: Seraina von Moos, Gesa Schalk, Thomas F. Mueller and Guido Laube

    Citation: Immunity & Ageing 2019 16:9

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  17. Content type: Editorial

    Ageing has a profound detrimental impact on almost all living organisms. Immune systems play a particularly important role in protection against external challenges (pathogens) and internal insults (cancer) bu...

    Authors: Nan-ping Weng and Graham Pawelec

    Citation: Immunity & Ageing 2019 16:8

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  18. Content type: Short report

    In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related r...

    Authors: Luca Massaccesi, Emanuela Galliera, Daniela Galimberti, Chiara Fenoglio, Marina Arcaro, Giancarlo Goi, Alessandra Barassi and Massimiliano Marco Corsi Romanelli

    Citation: Immunity & Ageing 2019 16:7

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  19. Content type: Research

    The use of Akkermansia muciniphila as potential therapeutic intervention is receiving increasing attention. Health benefits attributed to this bacterium include an improvement of metabolic disorders and exerting ...

    Authors: Benthe van der Lugt, Adriaan A. van Beek, Steven Aalvink, Ben Meijer, Bruno Sovran, Wilbert P. Vermeij, Renata M. C. Brandt, Willem M. de Vos, Huub F. J. Savelkoul, Wilma T. Steegenga and Clara Belzer

    Citation: Immunity & Ageing 2019 16:6

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  20. Content type: Short report

    Innate immunity utilizes components of sensory signal transduction such as bitter and sweet taste receptors. In fact, empirical evidence has shown bitter and sweet taste receptors to be an integral component o...

    Authors: Alberto Malovini, Giulia Accardi, Anna Aiello, Riccardo Bellazzi, Giuseppina Candore, Calogero Caruso, Mattia Emanuela Ligotti, Anna Maciag, Francesco Villa and Annibale A. Puca

    Citation: Immunity & Ageing 2019 16:5

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  21. Content type: Short report

    Pentraxin 3 (PTX3), an acute-phase inflammation protein produced by several cell types, has long been described as a possible biomarker for age-related cardiovascular and cerebrovascular diseases. Although sev...

    Authors: Albino Carrizzo, Claudio Procaccini, Paola Lenzi, Clorinda Fusco, Francesco Villa, Serena Migliarino, Massimiliano De Lucia, Francesco Fornai, Giuseppe Matarese, Annibale A. Puca and Carmine Vecchione

    Citation: Immunity & Ageing 2019 16:4

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  22. Content type: Research

    Apolipoprotein E4 (APOE4) and ageing are the most important known risk factors for late-onset Alzheimer’s disease (AD). In the present study, we determined the alterations of IgG, CD19, and Aβ in various brain...

    Authors: Lihang Zhang, Juan Xu, Jinchao Gao, Peiqing Chen, Ming Yin and Wenjuan Zhao

    Citation: Immunity & Ageing 2019 16:2

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  23. Content type: Research

    The plasma level of the inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is a strong predictor of disease development and premature mortality in the general population. Unhealthy...

    Authors: Thomas Huneck Haupt, Line Jee Hartmann Rasmussen, Thomas Kallemose, Steen Ladelund, Ove Andersen, Charlotta Pisinger and Jesper Eugen-Olsen

    Citation: Immunity & Ageing 2019 16:1

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  24. Content type: Research

    This study aimed to construct a biological age assessment formula for the Chinese population and to explore the effectiveness of double filtration plasmapheresis for anti-ageing and longevity.

    Authors: Xufeng Li, Jiren Zhang, Chen Sun, Yuanyuan Zhang, Rui Cai, Shilin Fu, Jingfen Zheng and Dehai Huang

    Citation: Immunity & Ageing 2018 15:33

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  25. Content type: Research

    The influence of age on basophils is poorly understood, as well as the effect of aging-associated microbiota on basophils. Therefore, we studied the influence of aging and aging-associated microbiota on basoph...

    Authors: Adriaan A. van Beek, Floris Fransen, Ben Meijer, Paul de Vos, Edward F. Knol and Huub F. J. Savelkoul

    Citation: Immunity & Ageing 2018 15:32

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  26. Content type: Research

    NK cells are cytotoxic lymphocytes of innate immunity composed of: cytotoxic CD56dim and immunoregulatory CD56bright cells. The study aimed to analyze the expression of cellular protective proteins: sirtuin 1 ...

    Authors: Lucyna Kaszubowska, Jerzy Foerster, Daria Schetz and Zbigniew Kmieć

    Citation: Immunity & Ageing 2018 15:31

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  27. Content type: Research

    Some components of Nutraceuticals (NUT) such as red yeast rice and Morus alba have demonstrated positive effects on the endothelial function in hypercholesterolemic subjects. Our aim was to compare the effects of...

    Authors: Roberta Esposito, Regina Sorrentino, Giuseppe Giugliano, Marisa Avvedimento, Roberta Paolillo, Ciro Santoro, Maria Scalamogna, Mafalda Esposito, Federica Ilardi, Francesco Rozza, Giovanni Esposito, Maurizio Galderisi and Valentina Trimarco

    Citation: Immunity & Ageing 2018 15:30

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  28. Content type: Research

    Previous reports showed that oral administration of Leuconostoc mesenteroides strain NTM048 increases IgA levels and CD4+ T cell population in feces and mice, respectively, as revealed by flow cytometric analysis...

    Authors: Reiko Kuroda, Hiroaki Higuchi, Keishirou Yoshida, Yasunori Yonejima, Keiko Hisa, Masanori Utsuyama, Kenji Osawa and Katsuiku Hirokawa

    Citation: Immunity & Ageing 2018 15:29

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  29. Content type: Letter to the Editor

    Improving influenza vaccine efficacy is a priority to reduce the burden of influenza-associated morbidity and mortality. By careful selection of individuals based on health we show sustained response to influe...

    Authors: Xavier Camous, Lucian Visan, Crystal Tan Tze Ying, Brian Abel, Ma Shwe Zin Nyunt, Vipin Narang, Michael Poidinger, Christophe Carre, Sanie Sesay, Nabil Bosco, Nicolas Burdin, Paul Anantharajah Tambyah, Ng Tze Pin and Anis Larbi

    Citation: Immunity & Ageing 2018 15:28

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  30. Content type: Research

    Patients with end-stage renal disease (ESRD) exhibit a premature aging phenotype of the immune system. Nevertheless, the etiology and impact of these changes in ESRD patients remain unknown.

    Authors: Yen-Ling Chiu, Kai-Hsiang Shu, Feng-Jung Yang, Tzu-Ying Chou, Ping-Min Chen, Fang-Yun Lay, Szu-Yu Pan, Cheng-Jui Lin, Nicolle H R Litjens, Michiel G H Betjes, Selma Bermudez, Kung-Chi Kao, Jean-San Chia, George Wang, Yu-Sen Peng and Yi-Fang Chuang

    Citation: Immunity & Ageing 2018 15:27

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  31. Content type: Research

    The aim of this study was to analyse the role of GM allotypes, i.e. the hereditary antigenic determinants expressed on immunoglobulin polypeptide chains, in the attainment of longevity. The role played by immu...

    Authors: Annibale A. Puca, Anna Ferrario, Anna Maciag, Giulia Accardi, Anna Aiello, Caterina Maria Gambino, Giuseppina Candore, Calogero Caruso, Aryan M. Namboodiri and Janardan P. Pandey

    Citation: Immunity & Ageing 2018 15:26

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    The Commentary to this article has been published in Immunity & Ageing 2018 15:25

  32. Content type: Research

    Sepsis is one of the common death factors in intensive care unit, which refers to the systemic inflammatory response syndrome caused by infection. It has many complications such as acute renal injury, shock, m...

    Authors: Yang Zhang, Ling Wang, Lei Meng, Guang-Ke Cao, Yu-Liang Zhao and Yu Wu

    Citation: Immunity & Ageing 2018 15:23

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  33. Content type: Review

    One of the most important determinants of aging-related changes is a complex biological process emerged recently and called “immunosenescence”. Immunosenescence refers to the inability of an aging immune syste...

    Authors: Salvatrice Mancuso, Melania Carlisi, Marco Santoro, Mariasanta Napolitano, Simona Raso and Sergio Siragusa

    Citation: Immunity & Ageing 2018 15:22

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  34. Content type: Research

    Recent studies show that C-reactive protein (CRP) is not only a biomarker but also a pathogenic mediator contributing to the development of inflammation and ageing-related diseases. However, serum levels of CR...

    Authors: Ying Tang, Peifen Liang, Junzhe Chen, Sha Fu, Bo Liu, Min Feng, Baojuan Lin, Ben Lee, Anping Xu and Hui Y. Lan

    Citation: Immunity & Ageing 2018 15:21

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  35. Content type: Short report

    In order to elucidate the causes for the increased mortality of aged patients with bacterial central nervous system (CNS) infections, we compared the course of Streptococcus pneumoniae (S. pneumoniae) meningitis ...

    Authors: Anja Manig, Sandra Ribes, Catharina Diesselberg, Stephanie Bunkowski, Roland Nau and Sandra Schütze

    Citation: Immunity & Ageing 2018 15:20

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  36. Content type: Research

    The elderly patient population is the most susceptible to influenza virus infection and its associated complications. Polypharmacy is common in the aged, who often have multiple co-morbidities. Previous studie...

    Authors: Divyansh Agarwal, Kenneth E. Schmader, Andrew V. Kossenkov, Susan Doyle, Raj Kurupati and Hildegund C. J. Ertl

    Citation: Immunity & Ageing 2018 15:19

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  37. Content type: Correction

    In the original publication of this article [1] there is an error in Fig. 3a as the labels “TM” and “VM” are in the wrong order for the last plot. The CD49d high cells should be “TM” and the CD49d low cells sh...

    Authors: Kathleen G. Lanzer, Tres Cookenham, William W. Reiley and Marcia A. Blackman

    Citation: Immunity & Ageing 2018 15:18

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    The original article was published in Immunity & Ageing 2018 15:17

  38. Content type: Research

    A diverse repertoire of naïve T cells is thought to be essential for a robust response to new infections. However, a key aspect of aging of the T cell compartment is a decline in numbers and diversity of perip...

    Authors: Kathleen G. Lanzer, Tres Cookenham, William W. Reiley and Marcia A. Blackman

    Citation: Immunity & Ageing 2018 15:17

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    The Correction to this article has been published in Immunity & Ageing 2018 15:18

  39. Content type: Research

    End-stage renal disease (ESRD) causes premature ageing of the immune system. However, it is not known whether hemodialysis (HD) and peritoneal dialysis (PD) similarly affect the T cell system.

    Authors: Didier Ducloux, Mathieu Legendre, Jamal Bamoulid, Jean-Michel Rebibou, Philippe Saas, Cécile Courivaud and Thomas Crepin

    Citation: Immunity & Ageing 2018 15:16

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  40. Content type: Research

    Accumulating evidence indicates that persistent human cytomegalovirus (HCMV) infection is associated with several health-related adverse outcomes including atherosclerosis and premature mortality in individual...

    Authors: Feng-Jung Yang, Kai-Hsiang Shu, Hung-Yuan Chen, I-Yu Chen, Fang-Yun Lay, Yi-Fang Chuang, Chien-Sheng Wu, Wan-Chuan Tsai, Yu-Sen Peng, Shih-Ping Hsu, Chih-Kang Chiang, George Wang and Yen-Ling Chiu

    Citation: Immunity & Ageing 2018 15:15

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  41. Content type: Research

    Abdominal obesity is an independent risk factor for coronary heart disease (CHD) and high serum triglyceride (TG) and free fatty acid levels may precipitate or aggravate CHD.

    Authors: Rui-Feng Yang, Hanlei Zhang, Zhongchun Wang, Xiao-Yong Liu and Zhi Lin

    Citation: Immunity & Ageing 2018 15:14

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  42. Content type: Research

    The pathogenesis of asthma, which is an allergic lung disease, is associated with a variety of allergens such as house dust mite, pollen, and mould, IgE containing serum IgE and allergen-specific-IgE, and infl...

    Authors: Kyung Mi Jo, Hyo Kyung Lim, Jae Woong Sull, Eugene Choi, Ji-Sook Lee, Mee Ae Cheong, Min Hwa Hong, Yoori Kim and In Sik Kim

    Citation: Immunity & Ageing 2018 15:13

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  43. Content type: Research

    Natural killer cells (NK cells) are cytotoxic lymphocytes of innate immunity that reveal some immunoregulatory properties, however, their role in the process of ageing is not completely understood. The study a...

    Authors: Lucyna Kaszubowska, Jerzy Foerster, Jan Jacek Kaczor, Daria Schetz, Tomasz Jerzy Ślebioda and Zbigniew Kmieć

    Citation: Immunity & Ageing 2018 15:12

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  44. Content type: Research

    Chronic rhinitis, pharyngitis and sinusitis are common health problems with a significant impact on public health, and are suspected to be influenced by ageing factors. Nasal inhalation with thermal water may ...

    Authors: Monica Neri, Luigi Sansone, Luisa Pietrasanta, Aliaksei Kisialiou, Eloisa Cabano, Marina Martini, Matteo A. Russo, Donatella Ugolini, Marco Tafani and Stefano Bonassi

    Citation: Immunity & Ageing 2018 15:10

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  45. Content type: Research

    Elderly people have experienced several influenza natural infections and seasonal vaccinations during their lives. The aim of this work was to evaluate in an elderly Spanish population the presence of antibodi...

    Authors: Ivan Sanz, Silvia Rojo, Sonia Tamames, Jose María Eiros and Raúl Ortiz de Lejarazu

    Citation: Immunity & Ageing 2018 15:9

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