Table 3 HI antibody response against four drifted epidemic A(H3N2) viruses circulating in Umbria (A/Perugia/06/12; A/Perugia/20/12; A/Perugia/44/12; A/Perugia/50/12) after IM-MF59 or ID influenza vaccine
Epidemic virus | Group (N.) | Seroprotection rate (%) | GMT | MFI | GMT corrected # | Seroconversion rate (%) | ||
|---|---|---|---|---|---|---|---|---|
[95% C.I.] | [95% C.I.] | [95% C.I.] | [95% C.I.] | [95% C.I.] | ||||
Pre-vacc. | 1 month | Pre-vacc. | 1 month | 1 month | 1 month | 1 month | ||
A/Perugia/06/12 | IM-MF59 | 32.5 | 70.0** | 20.7 | 43.6** | 2.1 | 1.9 | 27.5 |
(40) | [21.7-45.5] | [57.1-80.3] | [14.4-29.7] | [30.8-61.8] | [1.5-2.9] | [1.4-2.4] | [17.6-40.3] | |
ID | 45.0 | 82.5 | 24.2 | 58.6* | 2.4 | 2.5$$ | 35.0 | |
(40) | [32.8-57.9] | [70.6-90.2] | [16.7-35.0] | [41.1-83.5] | [1.7-3.5] | [1.6-3.1] | [23.9-48.0] | |
A/Perugia/20/12 | IM-MF59 | 25.0 | 47.5* | 15.4 | 35.4** | 2.3 | 1.9 | 25.0 |
(40) | [15.6-37.6] | [35.1-60.3] | [10.0-24.1] | [23.3-53.3] | [1.6-3.4] | [1.0-2.4] | [15.6-37.6] | |
ID | 37.5 | 72.5**$ | 18.0 | 38.0** | 2.1 | 1.9 | 17.5 | |
(40) | [26.1-50.5] | [59.7-82.4] | [12.1-26.9] | [26.6-54.3] | [1.5-3.0] | [1.4-2.4] | [9.8-29.4] | |
A/Perugia/44/12 | IM-MF59 | 32.5 | 67.5** | 20.0 | 50.1** | 2.5 | 2.1 | 37.5 |
(40) | [21.7-45.5] | [54.5-78.3] | [13.2-30.3] | [32.0-78.5] | [1.7-3.8] | [1.2-3.0] | [26.1-50.5] | |
ID | 55.0 $ | 87.5**$ | 28.3 | 56.6** | 2.0 | 2.6 | 25.0 | |
(40) | [42.1-67.2] | [76.4-93.8] | [18.6-42.9] | [41.2-77.6] | [1.4-2.9] | [2.0-3.0] | [15.6-37.6] | |
A/Perugia/50/12 | IM-MF59 | 50.0 | 82.5** | 26.9 | 61.7** | 2.3 | 2.6 | 25.0 |
(40) | [37.4-72.6] | [70.6-90.2] | [16.9-42.7] | [42.1-90.3] | [1.5-3.5] | [1.7-3.1] | [15.6-37.6] | |
ID | 65.0 | 90.0** | 33.7 | 75.9** | 2.3 | 2.4 | 20.0 | |
(40) | [52.0-76.1] | [79.5-59.4] | [21.2-53.4] | [50.6-113.9] | [1.5-3.3] | [1.8-2.8] | [11.6-32.2] | |