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Table 3 Percent frequency of chemokine receptor and activation marker positive leukocytes in SARS-CoV infected aged and juvenile monkeys

From: Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses

  Frequency of cellsa
Peripheral blood Day 1 Day 5 Day 10  
  Juvenile Aged Juvenile Aged Juvenile Aged Statistics
Monocytes        
   CCR1 5.0 ± 0.9 1.8 ± 0.4 1.0 ± 0.1 2.2 ± 1.7 2.5 ± 0.3 2.4 ± 0.6 d.p.i*
   CCR3 1.6 ± 0.4 1.9 ± 04 1.1 ± 01 2.2 ± 12 1.1 ± 01 2.4 ± 0.6 age*
   CD86 8.9 ± 13 3.8 ± 0.4 6.3 ± 2.0 3.9 ± 1.9 4.7 ± 0.3 5.2 ± 1.6 age*
DCs        
   CCR6 0.6 ± 0.3 0.3 ± 0.2 0.6 ± 0.2 0.0 ± 0.0 0.3 ± 01 0.2 ± 0.0 age**, d.p.i *
   CD86 1.4 ± 0.5 0.2 ± 0.0 2.9 ± 0.9 0.3 ± 0.0 0.2 ± 0.0 0.2 ± 0.0 age****
CD8 + T cells        
CCR5 6.9 ± 1.2 2.5 ± 0.4 1.8 ± 0.3 2.0 ± 0.5 3.7 ± 0.3 9.9 ± 3.4 d.p.i**
Lung Mock Day 5 Day 10  
  Juvenile Aged Juvenile Aged Juvenile Aged Statistics
Macrophages        
   CD86 20.5 ± 1.7 2.3 ± 0.1 36.4 ± 4.8 3.1 ± 1.1 34.2 ± 2.1 3.3 ± 1.7 age ****
DCs        
   CD86 1.1 ± 0.3 0.3 ± 0.1 3.7 ± 0.5 0.4 ± 0.1 2.0 ± 0.5 0.3 ± 0.1 age ****
  1. aAverage frequency of chemokine receptor or activation marker positive cells of total perhipheral blood or lung leukocytes. Monocytes (CD14 + HLADR+), peripheral blood dendritic cells (DCs: CD14-HLADR + CD11c+), CD8 T cells (CD3 + CD8+). Lung macrophages are defined as CD68 + HLADR + and lung DCs as CD68-HLADR + CD11c+. Gating strategies are show in Additional file 1: Figure S1, Additional file 2: Figure S2 and Additional file 4: Figure S3. Statistical results of 2-way ANOVas for age and days post infection (d.p.i.) are indicated at the right with asterisks denoting degree of sigrificance: *p < 0.05, **p < 0.005 ****p < 0.0001.