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Table 5 Avidity of anti-PPS antibodies from young and elderly.

From: Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I Antibody concentrations, avidity and functional activity

Pre-immune serum GMC (95% CI)
   CPS CPS + 22F P value
PPS4 Young 0.19 (0.07–0.32) 0.21 (0.04–0.38) 0.091
  Elderly 0.22 (0.13–0.31) 0.22 (0.12–0.31) 0.646
PPS14 Young 0.28 (0.21–0.36) 0.27 (0.19–0.35) 0.711
  Elderly 0.43 (0.27–0.59) 0.42 (0.27–0.56) 0.196
Post-immune serum GMC (95% CI)
   CPS CPS+22F P value
PPS4 Young 0.35 (0.22–0.49) 0.40 (0.25–0.55) 0.053
  Elderly 0.43 (0.23–0.63) 0.46 (0.26–0.65) 0.014
PPS14 Young 0.47 (0.33–0.62) 0.41 (0.29–0.54) 0.618
  Elderly 0.68 (0.50–0.85) 0.66 (0.48–0.84) 0.715
  1. Geometric Mean Concentration (GMC, M NaSCN) representing serum avidity by two different ELISA methods. CPS – serum adsorbed with CPS prior to ELISA. CPS+22F – serum absorbed with PPS22F and CPS prior to ELISA. P values shown in bold indicate a significant difference between absorption methods calculated using paired Student's T-test.