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Table 5 Avidity of anti-PPS antibodies from young and elderly.

From: Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I Antibody concentrations, avidity and functional activity

Pre-immune serum GMC (95% CI)

  

CPS

CPS + 22F

P value

PPS4

Young

0.19 (0.07–0.32)

0.21 (0.04–0.38)

0.091

 

Elderly

0.22 (0.13–0.31)

0.22 (0.12–0.31)

0.646

PPS14

Young

0.28 (0.21–0.36)

0.27 (0.19–0.35)

0.711

 

Elderly

0.43 (0.27–0.59)

0.42 (0.27–0.56)

0.196

Post-immune serum GMC (95% CI)

  

CPS

CPS+22F

P value

PPS4

Young

0.35 (0.22–0.49)

0.40 (0.25–0.55)

0.053

 

Elderly

0.43 (0.23–0.63)

0.46 (0.26–0.65)

0.014

PPS14

Young

0.47 (0.33–0.62)

0.41 (0.29–0.54)

0.618

 

Elderly

0.68 (0.50–0.85)

0.66 (0.48–0.84)

0.715

  1. Geometric Mean Concentration (GMC, M NaSCN) representing serum avidity by two different ELISA methods. CPS – serum adsorbed with CPS prior to ELISA. CPS+22F – serum absorbed with PPS22F and CPS prior to ELISA. P values shown in bold indicate a significant difference between absorption methods calculated using paired Student's T-test.