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Archived Comments for: Innate immunity and inflammation in ageing: a key for understanding age-related diseases

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  1. Biophysical-Semeiotic Consitutions play a pivotal role also in age-related diseases.

    Sergio Stagnaro, Biophysical Semeiotics Research Laboratory.

    12 June 2007


    we must agree with the statement that biophysical-semeiotic consitutions are as important in all other life-periods as in ageing (1-7). For instance, “Inflammation is not per se a negative phenomenon: it is the response of the immune system to the invasion of viruses or bacteria and other pathogens”. But, not all aged individuals have identical immune system, we can nowadays evaluate at the bedside in precise, rapid, and relaible way (1, 2). In addition, without Oncological Terrain and Oncological Real Risk, localized since birth in a well-defined biological system, oncogenesis is not possible (3-6, 8). Furthermore, aged subjects my be involved by so-called “senile” type 2 diabetes if they are positive SINCE BIRTH for both diabetic “and” dislipidaemic biophysical-Semeiotic Constitutions (7). Interestingly, I demonstrated earlier that all aged persons over 90 years, I meet in my practice during 44 years, were negative for Co Q10 deficiency syndrome (10-12).

    1) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico-Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ed. Travel Factory, Roma, 2004.

    2) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Ed. Travel Factory, Roma, 2005

    3) Stagnaro S., Stagnaro-Neri M., Oncological Terrain, conditio sine qua non of Oncogenesis, 2004:

    4) Stagnaro SergioBiophysical Semeiotic Constitutions, Genomics, and Cardio-Vascular Diseases. BMC Cardiovascular Disorders

    5) Stagnaro Sergio. "Genes, Oncological Terrain, and Breast Cancer" World Journal of Surgical Oncology., 2005,

    6) Stagnaro Sergio. Single Patient Based Medicine: its paramount role in Future Medicine. Public Library of Science. 2005.

    7) Stagnaro S. Newborne-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. The Lancet. March 06 2007.

    8) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004.

    9) Stagnaro S., Stagnaro-Neri M., La Melatonina nella Terapia del Terreno Oncologico e del “Reale Rischio” Oncologico. Ed. Travel Factory, Roma, 2004.

    10) Stagnaro S., Ipercolesterolemia e Coenzima Q10. The Pract. Ed. It. 133, 5-6, 1990

    11) Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemizante diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17, 1990

    12) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239.

    Competing interests

    None declared