Figure 3From: A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosisProposed mechanisms of increased sensitivity of aged TN and TCM CD8+ T cells to TNF-α-induced apoptosis. Signaling molecules downstream of TNFRs that activate NF-κB are decreased in aging resulting in decreased NF-κB activity and decreased expression of anti-apoptotic proteins.Back to article page