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Table 1 Serum antibody levels in aging BALB/c mice immunized with human PG

From: Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis

Age Heteroantibody (mg/ml) (anti-human PG) Autoantibody (μg/ml) (anti-mouse PG)
(months) n IgG1 IgG2a IgG1 IgG2a
1 48 3.32 ± 0.26 0.69 ± 0.12 41.6 ± 6.0 39.6 ± 7.3
2 34 5.61 ± 0.33 1.40 ± 0.24 111.1 ± 8.2* 86.7 ± 9.6*
3 30 7.88 ± 0.57 0.66 ± 0.14 108.5 ± 11.7* 104.5 ± 22.5*
4 27 5.72 ± 0.44 1.71 ± 0.29 50.0 ± 7.3 91.3 ± 23.5*
5 17 6.68 ± 0.47 1.09 ± 0.23 86.3 ± 8.5* 33.6 ± 13.5
7 20 6.43 ± 0.61 0.86 ± 0.13 63.1 ± 7.4 45.8 ± 8.8
9 28 5.65 ± 0.52 1.05 ± 0.13 65.7 ± 6.6 68.2 ± 14.3
11 9 2.50 ± 0.64 0.50 ± 0.11 46.0 ± 15.9 30.4 ± 8.2
  1. Serum levels of PG-specific hetero- and autoantibodies (against human and mouse
  2. PG, respectively) and number of animals in the individual age groups. Age (months) indicate when the first PG injection was given; animals were sacrificed 87 days later, when serum samples were collected. Significantly (p < 0.05) higher heteroantibody and *autoantibody concentrations compared to the 1-month-old group (bold face) are indicated.