Figure 1

Correlation between T-lymphocyte miR-92a level and age. The CD8⁺ T-lymphocyte miR-92a level significantly decreased with age (A), while CD4⁺ lymphocytes only showed a tendency for a decrease of miR-92a level with age (B). A significant decrease in the percentage of RO^-CD8⁺CD27⁺ fraction (C) or CD3⁺CD8⁺CD62L⁺ fraction (D) with age is evident. There is a significant positive correlation between CD8⁺ miR-92a level (x axis) and the percentage of RO^-CD8⁺CD27⁺ fraction (E) and CD3⁺CD8⁺CD62L⁺ fraction (F) (y axis), which tends to down-regulate with age (closed circles = 20 to 29 years; open circles = 30 to 39 years; open squares = aged 40 to 49 years; closed squares = older than 50 years).