Immune correlates of aging in outdoor-housed captive rhesus macaques (Macaca mulatta)

Immunity & Ageing

Table 2 Relationship between hematology values and age in rhesus macaques

Test^a	Correlation coefficient (r)^b	P	Mean values (± St. Dev.)
Test^a	Correlation coefficient (r)^b	P	Younger group (2–9 years)	Middle group 10–17 years	Older group 18–24 years	P ^c	Units
RBC	−0.1359	n.s.^d	5.64 ± 0.44	5.59 ± 0.53	5.5 ± 0.61	n.s.	x 10⁶ / μL
Hgb	−0.1145	n.s.	12.58 ± 0.85	12.59 ± 1.31	12.3 ± 1.3	n.s.	g / dL
Hct	−0.1276	n.s.	39.47 ± 3.22	39.22 ± 3.55	37.96 ± 6.48	n.s.	%
MCV	0.0766	n.s.	70.01 ± 2.85	70.35 ± 3.55	70.49 ± 3.79	n.s.	fL
MCH	−0.0011	n.s.	22.33 ± 0.96	22.60 ± 1.61	22.28 ± 1.79	n.s.	pg/cell
MCHC	−0.1029	n.s.	31.89 ± 0.94	32.11 ± 1.17	31.58 ± 1.59	n.s.	g / dL
RDW	0.0055	n.s.	13.49 ± 1.00	13.22 ± 2.62	13.61 ± 1.25	n.s.	%
Platelets	−0.1364	n.s.	4.04 ± 0.89	3.86 ± 0.93	3.69 ± 1.20	n.s.	x 10⁵ / μL
MPV	0.0613	n.s.	9.28 ± 0.92	8.90 ± 2.17	9.19 ± 1.311	n.s.	fL
WBC	−0.1768	0.0380	10.68 ± 5.97	9.72 ± 4.56	6.68 ± 2.94	0.0007	x 10³ / μL
Lymphocytes	−0.3052	0.0002	2.78 ± 1.18	2.70 ± 1.30	2.12 ± 0.66	0.0052	x 10³ / μL
Monocyte	−0.1989	0.0170	0.47 ± 0.24	0.42 ± 0.16	0.36 ± 0.14	0.0221	x 10³ / μL
Neutrophils	−0.2555	0.0020	7.07 ± 5.72	6.01 ± 4.38	4.03 ± 2.96	0.0068	x 10³ / μL
Eosinophils	−0.2710	0.0010	0.36 ± 0.29	0.29 ± 0.26	0.18 ± 0.15	0.0017	x 10³ / μL
Basophils	−0.3525	< 0.0001	0.04 ± 0.03	0.03 ± 0.03	0.02 ± 0.01	0.0004	x 10³ / μL

^a Abbreviations of tests; RBC, red blood cells; Hgb, hemoglobin, Hct, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; RDW, red blood cell distribution width; MPV, mean platelet volume; WBC, white blood cells.
^b Pearson correlation coefficients were calculated for each hematology test over age of the rhesus macaques. P < 0.05 was considered statistically significant.
^c Mean values of hematology tests were calculated for all animals and within groups of rhesus macaques. Student’s t Test was measured to determine statistically significant differences between the older and younger groups of animals. P < 0.05 was considered statistically significant.
^d Not significant, n.s.

ISSN: 1742-4933